Detalhe da pesquisa
1.
A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes.
Drug Metab Dispos
; 47(5): 484-492, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30787098
2.
A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.
Drug Metab Dispos
; 46(4): 346-356, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330218
3.
An exposure-response analysis based on rifampin suggests CYP3A4 induction is driven by AUC: an in vitro investigation.
Xenobiotica
; 47(8): 673-681, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27595796
4.
A "middle-out" approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling.
J Pharmacokinet Pharmacodyn
; 41(3): 197-209, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24718648
5.
Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.
Bioorg Med Chem Lett
; 23(1): 213-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200254
6.
Discovery of Diphenylacetamides as CXCR7 Inhibitors with Novel ß-Arrestin Antagonist Activity.
ACS Med Chem Lett
; 11(6): 1330-1334, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551020
7.
Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists.
Bioorg Med Chem Lett
; 19(16): 4555-9, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19625189
8.
Metabolism-guided design of short-acting calcium-sensing receptor antagonists.
ACS Med Chem Lett
; 1(5): 219-23, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900198