Detalhe da pesquisa
1.
Elevated In Vitro Kinase Activity in Peripheral Blood Mononuclear Cells of Leucine-Rich Repeat Kinase 2 G2019S Carriers: A Novel Enzyme-Linked Immunosorbent Assay-Based Method.
Mov Disord
; 35(11): 2095-2100, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32652692
2.
Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes.
Biochem J
; 476(3): 559-579, 2019 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30670570
3.
Nurr1:RXRα heterodimer activation as monotherapy for Parkinson's disease.
Proc Natl Acad Sci U S A
; 114(15): 3999-4004, 2017 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28348207
4.
P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity.
Biochem J
; 475(7): 1271-1293, 2018 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29519959
5.
Neuronal death signaling pathways triggered by mutant LRRK2.
Biochem Soc Trans
; 45(1): 123-129, 2017 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28202665
6.
LRRK2 Parkinson disease mutations enhance its microtubule association.
Hum Mol Genet
; 21(4): 890-9, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22080837
7.
The neurobiology of LRRK2 and its role in the pathogenesis of Parkinson's disease.
Neurochem Res
; 39(3): 576-92, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-23729298
8.
Longitudinal transcriptomic analysis of mouse sciatic nerve reveals pathways associated with age-related muscle pathology.
J Cachexia Sarcopenia Muscle
; 14(3): 1322-1336, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36905126
9.
Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts.
NPJ Parkinsons Dis
; 8(1): 73, 2022 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35676398
10.
Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death.
J Neurochem
; 119(3): 630-43, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21883213
11.
Defining (and blocking) neuronal death in Parkinson's disease: Does it matter what we call it?
Brain Res
; 1771: 147639, 2021 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34492263
12.
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.
J Neurosci
; 29(4): 1011-6, 2009 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-19176810
13.
The Future of Targeted Gene-Based Treatment Strategies and Biomarkers in Parkinson's Disease.
Biomolecules
; 10(6)2020 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32560161
14.
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.
Front Neurosci
; 14: 865, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33013290
15.
A novel cell death pathway that is partially caspase dependent, but morphologically non-apoptotic, elicited by proteasomal inhibition of rat sympathetic neurons.
J Neurochem
; 105(3): 653-65, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18194212
16.
Why the Gut Microbiome Must Be Considered When Evaluating the Impact of Pesticides on Parkinson's Disease Risk.
J Parkinsons Dis
; 13(7): 1077-1078, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37927278
17.
A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.
Sci Rep
; 8(1): 3455, 2018 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29472595
18.
LRRK2 and the "LRRKtosome" at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives.
Adv Neurobiol
; 14: 193-208, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28353285
19.
Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.
PLoS One
; 11(11): e0166053, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27832104
20.
Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.
J Neurosci
; 23(4): 1237-45, 2003 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12598612