Detalhe da pesquisa
1.
Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia.
Ann Hematol
; 102(11): 3049-3059, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37702821
2.
Onvansertib in Combination with FOLFIRI and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Phase Ib Clinical Study.
Clin Cancer Res
; 30(10): 2039-2047, 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38231047
3.
Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling.
Cancer Res
; 83(2): 219-238, 2023 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36413141
4.
Onvansertib and paclitaxel combined in platinum-resistant ovarian carcinomas.
Ther Adv Med Oncol
; 14: 17588359221095064, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35665077
5.
A novel PLK1 inhibitor onvansertib effectively sensitizes MYC-driven medulloblastoma to radiotherapy.
Neuro Oncol
; 24(3): 414-426, 2022 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34477871
6.
A Phase Ib Study of Onvansertib, a Novel Oral PLK1 Inhibitor, in Combination Therapy for Patients with Relapsed or Refractory Acute Myeloid Leukemia.
Clin Cancer Res
; 26(23): 6132-6140, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32998961
7.
Onvansertib, a polo-like kinase 1 inhibitor, inhibits prostate stromal cell growth and prostate smooth muscle contraction, which is additive to inhibition by α1-blockers.
Eur J Pharmacol
; 873: 172985, 2020 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32017934
8.
Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer.
PLoS One
; 14(11): e0224420, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31751384
9.
Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy.
PLoS One
; 12(12): e0189051, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29211796