Detalhe da pesquisa
1.
Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-ß-hydroxysteroid dehydrogenase (AKR1C3).
Bioorg Med Chem
; 22(3): 967-77, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24411201
2.
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
J Med Chem
; 65(20): 13879-13891, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36200480
3.
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.
Eur J Med Chem
; 178: 530-543, 2019 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31212132
4.
Correction to "Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta".
J Med Chem
; 2023 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36815444
5.
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
J Med Chem
; 50(8): 1958-72, 2007 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17371003
6.
Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.
J Med Chem
; 58(8): 3611-25, 2015 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25849762
7.
Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3.
Eur J Med Chem
; 62: 738-44, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23454516
8.
3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-ß-hydroxysteroid dehydrogenase AKR1C3.
J Med Chem
; 55(17): 7746-58, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22877157
9.
Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2.
J Med Chem
; 54(2): 580-90, 2011 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-21186793
10.
2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).
Bioorg Med Chem Lett
; 13(18): 3083-6, 2003 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12941339