Detalhe da pesquisa
1.
RNAi mediated silencing of STAT3/PD-L1 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors.
Mol Ther
; 32(6): 1895-1916, 2024 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38549376
2.
Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA Synthesis.
J Virol
; 96(24): e0115022, 2022 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36448800
3.
Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA.
J Virol
; 95(18): e0057421, 2021 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34191584
4.
The Dihydroquinolizinone Compound RG7834 Inhibits the Polyadenylase Function of PAPD5 and PAPD7 and Accelerates the Degradation of Matured Hepatitis B Virus Surface Protein mRNA.
Antimicrob Agents Chemother
; 65(1)2020 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33046485
5.
Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation.
Antimicrob Agents Chemother
; 62(6)2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29555628
6.
Nonstructural protein 5A (NS5A) and human replication protein A increase the processivity of hepatitis C virus NS5B polymerase activity in vitro.
J Virol
; 89(1): 165-80, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25320291
7.
Novel Ranking System for Identifying Efficacious Anti-Influenza Virus PB2 Inhibitors.
Antimicrob Agents Chemother
; 59(10): 6007-16, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26169418
8.
Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit.
Antimicrob Agents Chemother
; 59(3): 1569-82, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25547360
9.
Genotypic and phenotypic analyses of hepatitis C virus variants observed in clinical studies of VX-222, a nonnucleoside NS5B polymerase inhibitor.
Antimicrob Agents Chemother
; 58(9): 5456-65, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24982088
10.
Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations.
Antimicrob Agents Chemother
; 57(9): 4417-26, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23836176
11.
In vitro phenotypic characterization of hepatitis C virus NS3 protease variants observed in clinical studies of telaprevir.
Antimicrob Agents Chemother
; 57(12): 6236-45, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24100495
12.
Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein.
Antiviral Res
; 197: 105211, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34826506
13.
Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1.
Nat Commun
; 12(1): 1222, 2021 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33619272
14.
Publisher Correction: Circulating serum HBsAg level is a biomarker for HBV-specific T and B cell responses in chronic hepatitis B patients.
Sci Rep
; 10(1): 5947, 2020 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32231233
15.
Circulating serum HBsAg level is a biomarker for HBV-specific T and B cell responses in chronic hepatitis B patients.
Sci Rep
; 10(1): 1835, 2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32020034
16.
Inhibition of HBV replication by N-hydroxyisoquinolinedione and N-hydroxypyridinedione ribonuclease H inhibitors.
Antiviral Res
; 164: 70-80, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30768944
17.
A morpholino oligomer targeting highly conserved internal ribosome entry site sequence is able to inhibit multiple species of picornavirus.
Antimicrob Agents Chemother
; 52(6): 1970-81, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18347107
18.
HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element.
Antiviral Res
; 149: 191-201, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29133129
19.
Discovery of Novel, Orally Bioavailable ß-Amino Acid Azaindole Inhibitors of Influenza PB2.
ACS Med Chem Lett
; 8(2): 256-260, 2017 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28197322
20.
Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors.
J Med Chem
; 59(15): 7138-51, 2016 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27385654