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Am J Obstet Gynecol ; 207(4): 297.e1-8, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22867687

RESUMO

OBJECTIVE: Genital tract secretions exhibit bactericidal activity against Escherichia coli. We hypothesized that this defense may be modulated during pregnancy. STUDY DESIGN: Secretions were collected by vaginal swab from 70 pregnant women (35-37 weeks' gestation) and 35 nonpregnant controls. We mixed E coli with swab eluants or control buffer and colonies enumerated to measure bactericidal activity. Cytokines, chemokines, and antimicrobial peptides were quantified by multiplex or enzyme-linked immunosorbent assay. RESULTS: Pregnant women had significantly greater bactericidal activity, higher concentrations of proinflammatory cytokines, and lower levels of beta defensins compared to controls. Seven (10%) pregnant and 8 (23%) nonpregnant women were vaginally colonized with E coli; colonization was inversely associated with bactericidal activity. CONCLUSION: The soluble mucosal immune environment is altered in pregnancy. We speculate that the observed changes may protect against colonization and ascending infection and could provide a biomarker to identify pregnant women at risk for infectious complications including preterm birth.


Assuntos
Quimiocinas/metabolismo , Citocinas/metabolismo , Escherichia coli/crescimento & desenvolvimento , Vagina/imunologia , Adulto , Feminino , Humanos , Gravidez , Vagina/metabolismo , Esfregaço Vaginal
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