Detalhe da pesquisa
1.
Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site.
Proc Natl Acad Sci U S A
; 118(9)2021 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33619102
2.
Fluorescence spectral shape analysis for nucleotide identification.
Proc Natl Acad Sci U S A
; 116(31): 15386-15391, 2019 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31308243
3.
In Vivo Evaluation of (-)-Zampanolide Demonstrates Potent and Persistent Antitumor Efficacy When Targeted to the Tumor Site.
Molecules
; 27(13)2022 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35807495
4.
Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA.
Mol Pharmacol
; 100(4): 309-318, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34312217
5.
Taccalonolide C-6 Analogues, Including Paclitaxel Hybrids, Demonstrate Improved Microtubule Polymerizing Activities.
J Nat Prod
; 84(6): 1799-1805, 2021 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34110822
6.
Efficacy of a Covalent Microtubule Stabilizer in Taxane-Resistant Ovarian Cancer Models.
Molecules
; 26(13)2021 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34279417
7.
Targeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural products.
Nat Prod Rep
; 37(5): 634-652, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31764930
8.
Leucinostatins from Ophiocordyceps spp. and Purpureocillium spp. Demonstrate Selective Antiproliferative Effects in Cells Representing the Luminal Androgen Receptor Subtype of Triple Negative Breast Cancer.
J Nat Prod
; 83(6): 2010-2024, 2020 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-32510949
9.
Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea.
J Nat Prod
; 83(7): 2269-2280, 2020 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32649211
10.
Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris.
J Nat Prod
; 83(3): 584-592, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32105068
11.
CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.
J Nat Prod
; 83(10): 3080-3092, 2020 10 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33021790
12.
Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides.
Proc Natl Acad Sci U S A
; 114(43): E8957-E8966, 2017 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29073092
13.
Eribulin rapidly inhibits TGF-ß-induced Snail expression and can induce Slug expression in a Smad4-dependent manner.
Br J Cancer
; 121(7): 611-621, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31481735
14.
Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype.
Breast Cancer Res Treat
; 177(2): 345-355, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31230251
15.
Microtubule-Targeting Drugs: More than Antimitotics.
J Nat Prod
; 82(3): 680-685, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30835122
16.
In Situ Ring Contraction and Transformation of the Rhizoxin Macrocycle through an Abiotic Pathway.
J Nat Prod
; 82(4): 886-894, 2019 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30865445
17.
Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines.
J Nat Prod
; 82(4): 928-936, 2019 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30830773
18.
Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers.
J Nat Prod
; 82(3): 583-588, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30799622
19.
Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.
Int J Mol Sci
; 20(6)2019 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30897704
20.
Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development.
J Cell Sci
; 129(17): 3282-94, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27422099