Detalhe da pesquisa
1.
Protection of Catalytic Cofactors by Polypeptides as a Driver for the Emergence of Primordial Enzymes.
Mol Biol Evol
; 40(6)2023 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37235753
2.
Immunoanalytical Approach for Detecting and Identifying Ancestral Peptide Biomarkers in Early Earth Analogue Environments.
Anal Chem
; 95(12): 5323-5330, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36926836
3.
Efficient Base-Catalyzed Kemp Elimination in an Engineered Ancestral Enzyme.
Int J Mol Sci
; 23(16)2022 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36012203
4.
Ancestral Resurrection and Directed Evolution of Fungal Mesozoic Laccases.
Appl Environ Microbiol
; 86(14)2020 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32414792
5.
Non-conservation of folding rates in the thioredoxin family reveals degradation of ancestral unassisted-folding.
Biochem J
; 476(23): 3631-3647, 2019 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31750876
6.
Equilibrium partially folded states of B. licheniformis[Formula: see text]-lactamase.
Eur Biophys J
; 48(4): 341-348, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30929094
7.
Engineering ancestral protein hyperstability.
Biochem J
; 473(20): 3611-3620, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27528732
8.
Evolution of conformational dynamics determines the conversion of a promiscuous generalist into a specialist enzyme.
Mol Biol Evol
; 32(1): 132-43, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25312912
9.
Mutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history.
Mol Biol Evol
; 32(2): 440-55, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25392342
10.
Correction for Gomez-Fernandez et al., "Ancestral Resurrection and Directed Evolution of Fungal Mesozoic Laccases".
Appl Environ Microbiol
; 86(17)2020 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32816744
11.
Phenotypic comparisons of consensus variants versus laboratory resurrections of Precambrian proteins.
Proteins
; 82(6): 887-96, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24710963
12.
Hyperstability and substrate promiscuity in laboratory resurrections of Precambrian ß-lactamases.
J Am Chem Soc
; 135(8): 2899-902, 2013 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23394108
13.
Protection of catalytic cofactors by polypeptides as a driver for the emergence of primordial enzymes.
bioRxiv
; 2023 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993774
14.
Host diversification is concurrent with linear motif evolution in a Mastadenovirus hub protein.
J Mol Biol
; 434(10): 167563, 2022 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35351519
15.
A protocol to study bacteriophage adaptation to new hosts.
STAR Protoc
; 2(3): 100784, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34485945
16.
Combining Ancestral Reconstruction with Folding-Landscape Simulations to Engineer Heterologous Protein Expression.
J Mol Biol
; 433(24): 167321, 2021 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34687715
17.
Evidence for a role of phenotypic mutations in virus adaptation.
iScience
; 24(4): 102257, 2021 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33817569
18.
Hinge-shift mechanism as a protein design principle for the evolution of ß-lactamases from substrate promiscuity to specificity.
Nat Commun
; 12(1): 1852, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33767175
19.
Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase.
Nat Commun
; 12(1): 380, 2021 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33452262
20.
Preparation and biophysical characterization of recombinant Pseudomonas aeruginosa phosphorylcholine phosphatase.
Protein Expr Purif
; 71(2): 153-9, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20064618