Detalhe da pesquisa
1.
Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage.
J Pharmacol Exp Ther
; 385(2): 106-116, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36849412
2.
Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas.
N Engl J Med
; 375(26): 2550-2560, 2016 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-28029918
3.
Synapse Formation in Monosynaptic Sensory-Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42.
J Neurosci
; 36(21): 5724-35, 2016 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27225763
4.
Oligodendrocyte RasG12V expressed in its endogenous locus disrupts myelin structure through increased MAPK, nitric oxide, and notch signaling.
Glia
; 65(12): 1990-2002, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28856719
5.
Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.
Cancer Cell
; 13(2): 105-16, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242511
6.
The protein tyrosine phosphatase Shp2 is required for the generation of oligodendrocyte progenitor cells and myelination in the mouse telencephalon.
J Neurosci
; 34(10): 3767-78, 2014 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24599474
7.
Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1.
Pediatr Blood Cancer
; 62(10): 1709-16, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25907661
8.
The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development.
J Neurosci
; 33(46): 17967-75, 2013 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24227708
9.
Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation.
Development
; 138(18): 4085-95, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21831918
10.
Schwann cells modulate nociception in neurofibromatosis 1.
JCI Insight
; 9(2)2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38258905
11.
Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.
Acta Neuropathol
; 125(1): 159-68, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23099891
12.
Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.
Cancer Cell
; 7(1): 65-75, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15652750
13.
Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.
Sarcoma
; 2012: 620834, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23319880
14.
P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis.
Elife
; 112022 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35311647
15.
WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth.
Oncogene
; 40(24): 4229-4241, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34079083
16.
Cdkn2a Loss in a Model of Neurofibroma Demonstrates Stepwise Tumor Progression to Atypical Neurofibroma and MPNST.
Cancer Res
; 80(21): 4720-4730, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32816910
17.
Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice.
JCI Insight
; 4(3)2019 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30728335
18.
STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma.
Oncogene
; 38(15): 2876-2884, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30542122
19.
Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.
Cancer Cell
; 33(2): 292-308.e7, 2018 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29438698
20.
Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis.
Mol Cell Biol
; 23(6): 2213-24, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12612091