1.
Bioorg Med Chem Lett
; 19(2): 524-7, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19064318
RESUMO
3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.
Assuntos
Antibacterianos/farmacologia , Proteínas de Bactérias/antagonistas & inibidores , Benzamidas/farmacologia , Proteínas do Citoesqueleto/antagonistas & inibidores , Staphylococcus/efeitos dos fármacos , Antibacterianos/química , Benzamidas/química , Testes de Sensibilidade Microbiana , Relação Estrutura-Atividade
2.
J Med Chem
; 53(10): 3927-36, 2010 May 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20426423
RESUMO
3-Methoxybenzamide (1) is a weak inhibitor of the essential bacterial cell division protein FtsZ. Alkyl derivatives of 1 are potent antistaphylococcal compounds with suboptimal drug-like properties. Exploration of the structure-activity relationships of analogues of these inhibitors led to the identification of potent antistaphylococcal compounds with improved pharmaceutical properties.