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1.
Magn Reson Med ; 91(6): 2358-2373, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38193277

RESUMO

PURPOSE: Spoke pulses improve excitation homogeneity in parallel-transmit MRI. We propose an efficient global optimization algorithm, Bayesian optimization of gradient trajectory (BOGAT), for single-slice and simultaneous multislice imaging. THEORY AND METHODS: BOGAT adds an outer loop to optimize kT-space positions. For each position, the RF coefficients are optimized (e.g., with magnitude least squares) and the cost function evaluated. Bayesian optimization progressively estimates the cost function. It automatically chooses the kT-space positions to sample, to achieve fast convergence, often coming close to the globally optimal spoke positions. We investigated the typical features of spokes cost functions by a grid search with field maps comprising 85 slabs from 14 volunteers. We tested BOGAT in this database, and prospectively in a phantom and in vivo. We compared the vendor-provided Fourier transform approach with the same magnitude least squares RF optimizer. RESULTS: The cost function is nonconvex and seen empirically to be piecewise smooth with discontinuities where the underlying RF optimum changes sharply. BOGAT converged to within 10% of the global minimum cost within 30 iterations in 93% of slices in our database. BOGAT achieved up to 56% lower flip angle RMS error (RMSE) or 55% lower pulse energy in phantoms versus the Fourier transform approach, and up to 30% lower RMSE and 29% lower energy in vivo with 7.8 s extra computation. CONCLUSION: BOGAT efficiently estimated near-global optimum spoke positions for the two-spoke tests, reducing flip-angle RMSE and/or pulse energy in a computation time (˜10 s), which is suitable for online optimization.


Assuntos
Algoritmos , Imageamento por Ressonância Magnética , Humanos , Teorema de Bayes , Imageamento por Ressonância Magnética/métodos , Imagens de Fantasmas , Análise dos Mínimos Quadrados , Encéfalo/diagnóstico por imagem
2.
NMR Biomed ; : e5165, 2024 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-38807311

RESUMO

We present a sequence building block (SBB) that embeds magnetic resonance spectroscopy (MRS) into another sequence on the Siemens VE platform without any custom hardware. This enables dynamic studies such as functional MRS (fMRS), dynamic shimming and frequency correction, and acquisition of navigator images for motion correction. The SBB supports nonlocalised spectroscopy (free induction decay), STimulated Echo Acquisition Mode single voxel spectroscopy, and 1D, 2D and 3D phase-encoded chemical shift imaging. It can embed 1H or X-nuclear MRS into a 1H sequence; and 1H-MRS into an X-nuclear sequence. We demonstrate integration into the vendor's gradient-recalled echo sequence. We acquire test data in phantoms with three coils (31P/1H, 13C/1H and 2H/1H) and in two volunteers on a 7-T Terra MRI scanner. Fifteen lines of code are required to insert the SBB into a sequence. Spectra and images are acquired successfully in all cases in phantoms, and in human abdomen and calf muscle. Phantom comparison of signal-to-noise ratio and linewidth showed that the SBB has negligible effects on image and spectral quality, except that it sometimes produces a nuclear Overhauser effect (NOE) signal enhancement for multinuclear applications in line with conventional 1H NOE pulses. Our new SBB embeds MRS into a host imaging or spectroscopy sequence in 15 lines of code. It allows homonuclear and heteronuclear interleaving. The package is available through the standard C2P procedure. We hope this will lower the barrier for entry to studies applying dynamic fMRS and for online motion correction and B0-shim updating.

3.
Alzheimers Dement ; 20(4): 2779-2793, 2024 04.
Artigo em Inglês | MEDLINE | ID: mdl-38421123

RESUMO

INTRODUCTION: Entorhinal cortex (EC) is the first cortical region to exhibit neurodegeneration in Alzheimer's disease (AD), associated with EC grid cell dysfunction. Given the role of grid cells in path integration (PI)-based spatial behaviors, we predicted that PI impairment would represent the first behavioral change in adults at risk of AD. METHODS: We compared immersive virtual reality (VR) PI ability to other cognitive domains in 100 asymptomatic midlife adults stratified by hereditary and physiological AD risk factors. In some participants, behavioral data were compared to 7T magnetic resonance imaging (MRI) measures of brain structure and function. RESULTS: Midlife PI impairments predicted both hereditary and physiological AD risk, with no corresponding multi-risk impairment in episodic memory or other spatial behaviors. Impairments associated with altered functional MRI signal in the posterior-medial EC. DISCUSSION: Altered PI may represent the transition point from at-risk state to disease manifestation in AD, prior to impairment in other cognitive domains.


Assuntos
Doença de Alzheimer , Adulto , Humanos , Doença de Alzheimer/patologia , Córtex Entorrinal/patologia , Encéfalo/patologia , Imageamento por Ressonância Magnética/métodos
4.
Magn Reson Imaging ; 111: 35-46, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38547935

RESUMO

Diffusion MRI (dMRI) is inherently limited by SNR. Scanning at 7 T increases intrinsic SNR but 7 T MRI scans suffer from regions of signal dropout, especially in the temporal lobes and cerebellum. We applied dynamic parallel transmit (pTx) to allow whole-brain 7 T dMRI and compared with circularly polarized (CP) pulses in 6 subjects. Subject-specific 2-spoke dynamic pTx pulses were designed offline for 8 slabs covering the brain. We used vendor-provided B0 and B1+ mapping. Spokes positions were set using the Fourier difference approach, and RF coefficients optimized with a Jacobi-matrix high-flip-angle optimizer. Diffusion data were analyzed with FSL. Comparing whole-brain averages for pTx against CP scans: mean flip angle error improved by 15% for excitation (2-spoke-VERSE 15.7° vs CP 18.4°, P = 0.012) and improved by 14% for refocusing (2-spoke-VERSE 39.7° vs CP 46.2°, P = 0.008). Computed spin-echo signal standard deviation improved by 14% (2-spoke-VERSE 0.185 vs 0.214 CP, P = 0.025). Temporal SNR increased by 5.4% (2-spoke-VERSE 8.47 vs CP 8.04, P = 0.004) especially in the inferior temporal lobes. Diffusion fitting uncertainty decreased by 6.2% for first fibers (2-spoke VERSE 0.0655 vs CP 0.0703, P < 0.001) and 1.3% for second fibers (2-spoke VERSE 0.139 vs CP 0.141, P = 0.01). In conclusion, dynamic parallel transmit improves the uniformity of 7 T diffusion-weighted imaging. In future, less restrictive SAR limits for parallel transmit scans are expected to allow further improvements.


Assuntos
Encéfalo , Imagem de Difusão por Ressonância Magnética , Razão Sinal-Ruído , Humanos , Imagem de Difusão por Ressonância Magnética/métodos , Encéfalo/diagnóstico por imagem , Adulto , Masculino , Feminino , Processamento de Imagem Assistida por Computador/métodos , Algoritmos , Reprodutibilidade dos Testes
5.
Ann Clin Transl Neurol ; 11(5): 1359-1364, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38561955

RESUMO

Neuroferritinopathy is a disorder of neurodegeneration with brain iron accumulation that has no proven disease-modifying treatments. Clinical trials require biomarkers of iron deposition. We examined brain iron accumulation in one presymptomatic FTL mutation carrier, two individuals with neuroferritinopathy and one healthy control using ultra-high-field 7T MRI. There was increased magnetic susceptibility, suggestive of iron deposition, in superficial and deep gray matter in both presymptomatic and symptomatic neuroferritinopathy. Cavitation of the putamen and globus pallidus increased with disease stage and at follow up. The widespread brain iron deposition in presymptomatic and early disease provides an opportunity for monitoring disease-modifying intervention.


Assuntos
Distúrbios do Metabolismo do Ferro , Ferro , Imageamento por Ressonância Magnética , Distrofias Neuroaxonais , Humanos , Distrofias Neuroaxonais/diagnóstico por imagem , Distrofias Neuroaxonais/genética , Distrofias Neuroaxonais/metabolismo , Distrofias Neuroaxonais/patologia , Distúrbios do Metabolismo do Ferro/diagnóstico por imagem , Distúrbios do Metabolismo do Ferro/metabolismo , Distúrbios do Metabolismo do Ferro/genética , Ferro/metabolismo , Adulto , Masculino , Feminino , Encéfalo/diagnóstico por imagem , Encéfalo/metabolismo , Pessoa de Meia-Idade , Apoferritinas/metabolismo , Apoferritinas/genética
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