Detalhe da pesquisa
1.
A novel approach to study multi-domain motions in JAK1's activation mechanism based on energy landscape.
Brief Bioinform
; 25(2)2024 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38446738
2.
Structural Analysis of Janus Tyrosine Kinase Variants in Hematological Malignancies: Implications for Drug Development and Opportunities for Novel Therapeutic Strategies.
Int J Mol Sci
; 24(19)2023 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37834019
3.
JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation.
Int J Mol Sci
; 24(15)2023 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37569303
4.
JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling.
Int J Mol Sci
; 24(7)2023 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37047778
5.
Quadruple and Truncated MEK3 Mutants Identified from Acute Lymphoblastic Leukemia Promote Degradation and Enhance Proliferation.
Int J Mol Sci
; 22(22)2021 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34830095
6.
Impact of CTLA-4 blockade in conjunction with metronomic chemotherapy on preclinical breast cancer growth.
Br J Cancer
; 116(3): 324-334, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28056464
7.
Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment.
Tumour Biol
; 37(9): 12643-12654, 2016 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-27444277
8.
Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.
J Biol Chem
; 288(10): 7137-46, 2013 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23341462
9.
Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.
J Biol Chem
; 287(20): 16596-608, 2012 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22442148
10.
Phosphorylation of Tyrosine 841 Plays a Significant Role in JAK3 Activation.
Life (Basel)
; 13(4)2023 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37109511
11.
Rapid Shift from SARS-CoV-2 Delta to Omicron Sub-Variants within a Dynamic Southern U.S. Borderplex.
Viruses
; 15(3)2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36992367
12.
Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction.
Sci Rep
; 11(1): 16951, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34417497
13.
The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border.
Int J Environ Res Public Health
; 18(14)2021 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34299796
14.
The Many Faces of JAKs and STATs Within the COVID-19 Storm.
Front Immunol
; 12: 690477, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34326843
15.
Pharmacodynamic biomarkers in metronomic chemotherapy: multiplex cytokine measurements in gastrointestinal cancer patients.
Clin Exp Med
; 21(1): 149-159, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33048259
16.
Analysis of Janus tyrosine kinase phosphorylation and activation.
Methods Mol Biol
; 967: 3-20, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23296718
17.
Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells.
PLoS One
; 8(2): e57326, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23451206
18.
Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways.
FEBS Lett
; 584(8): 1515-20, 2010 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-20211620