Detalhe da pesquisa
1.
(p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains.
Mol Cell
; 81(16): 3310-3322.e6, 2021 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34416138
2.
RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis.
Mol Cell
; 81(15): 3160-3170.e9, 2021 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34174184
3.
Activation of the Stringent Response by Loading of RelA-tRNA Complexes at the Ribosomal A-Site.
Mol Cell
; 70(1): 95-105.e4, 2018 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29625042
4.
Structure of SpoT reveals evolutionary tuning of catalysis via conformational constraint.
Nat Chem Biol
; 19(3): 334-345, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36470996
5.
Structural basis for HflXr-mediated antibiotic resistance in Listeria monocytogenes.
Nucleic Acids Res
; 50(19): 11285-11300, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36300626
6.
Photorhabdus antibacterial Rhs polymorphic toxin inhibits translation through ADP-ribosylation of 23S ribosomal RNA.
Nucleic Acids Res
; 49(14): 8384-8395, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34255843
7.
Ribosome association primes the stringent factor Rel for tRNA-dependent locking in the A-site and activation of (p)ppGpp synthesis.
Nucleic Acids Res
; 49(1): 444-457, 2021 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33330919
8.
Fatty acid starvation activates RelA by depleting lysine precursor pyruvate.
Mol Microbiol
; 112(4): 1339-1349, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31400173
9.
Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases.
Proc Natl Acad Sci U S A
; 112(16): 5171-6, 2015 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25848049
10.
Alarmone (p)ppGpp regulates the transition from pathogenicity to mutualism in Photorhabdus luminescens.
Mol Microbiol
; 100(4): 735-47, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26845750
11.
Bacterial global regulators DksA/ppGpp increase fidelity of transcription.
Nucleic Acids Res
; 43(3): 1529-36, 2015 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25605801
12.
Rapid Curtailing of the Stringent Response by Toxin-Antitoxin Module-Encoded mRNases.
J Bacteriol
; 198(14): 1918-1926, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27137501
13.
Tagetitoxin inhibits transcription by stabilizing pre-translocated state of the elongation complex.
Nucleic Acids Res
; 41(20): 9257-65, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23935117
14.
Controlled interplay between trigger loop and Gre factor in the RNA polymerase active centre.
Nucleic Acids Res
; 39(10): 4352-9, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21266474
15.
Stepwise mechanism for transcription fidelity.
BMC Biol
; 8: 54, 2010 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20459653
16.
Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools.
ACS Chem Biol
; 16(9): 1680-1691, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34477366
17.
The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of 'Long' RelA-SpoT Homolog Enzymes by Ribosomal Complexes.
Front Microbiol
; 11: 277, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184768
18.
(p)ppGpp-mediated stress response induced by defects in outer membrane biogenesis and ATP production promotes survival in Escherichia coli.
Sci Rep
; 9(1): 2934, 2019 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30814571
19.
Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA.
Front Microbiol
; 10: 1966, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31507571
20.
Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase.
mBio
; 10(3)2019 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31213559