RESUMO
A long-surviving clinical case of suspected Morquio's syndrome is described. The locomotorium (vertebral dwarfism, hyphoscoliosis, but no hypoplasia of the odontoid process of the epistropheus, platyspondylia), cardiopulmonary (aortic insufficiency, arterial calcification, varices) visual (opaque lens on right eye, sclerosis of the lenticular lamellae but no corneal opacity on left eye) acoustic (deafness) and gastroenteric systems (hepatomegaly) are analysed. No pathological granulations were noted in the leukocytes. The plasmatic lysosome enzymes were normal and alpha-fucosidase subnormal. Abnormal keratan sulphate secretion was noted in the daily urine. All this would explain the patient's long survival.
Assuntos
Mucopolissacaridose IV/patologia , Adulto , Insuficiência da Valva Aórtica/etiologia , Grânulos Citoplasmáticos , Glicosaminoglicanos/urina , Sopros Cardíacos , Hepatomegalia/etiologia , Humanos , Deficiência Intelectual/etiologia , Leucócitos/citologia , Lisossomos/enzimologia , Masculino , Mucopolissacaridose IV/mortalidade , Coluna Vertebral/anormalidades , Tórax/anormalidadesAssuntos
Glicosídeos Digitálicos/intoxicação , Insuficiência Cardíaca/tratamento farmacológico , Idoso , Arritmias Cardíacas/induzido quimicamente , Transtornos da Coagulação Sanguínea/induzido quimicamente , Doenças do Sistema Nervoso Central/induzido quimicamente , Glicosídeos Digitálicos/uso terapêutico , Toxidermias , Feminino , Gastroenteropatias/induzido quimicamente , Bloqueio Cardíaco/induzido quimicamente , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos da Visão/induzido quimicamenteRESUMO
The research over 1023 patients examined in a metallurgical firm for prevalence of essential hypertension has proven that 144 subjects were hypertensive (5 secondary and 139 essential hypertension). 51 patients (35.4%) did not know to be hypertensive, 26 (18%) were without therapy and 57 (39.5%) were inadequately treated. 75 subjects with essential hypertension were treated once daily with Atenolol 100 mg. After a six months treatment 85.4% of patients reached a good control of blood pressure (lying diastolic blood pressure less than or equal to 95 mmHg). Atenolol was well tolerated, few collateral effects have been encountered (13.3%) but mainly the treatment did not cause weakness nor diminished the work capability of the subjects which instead had proven to happen with non selective beta-blocking drugs.