Detalhe da pesquisa
1.
Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAA Receptor.
Mol Pharmacol
; 104(3): 115-131, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37316350
2.
The Antinociceptive Activity of (E)-3-(thiophen-2-yl)- N -(p-tolyl)acrylamide in Mice Is Reduced by (E)-3-(furan-2-yl)- N -methyl- N -(p-tolyl)acrylamide Through Opposing Modulatory Mechanisms at the α7 Nicotinic Acetylcholine Receptor.
Anesth Analg
; 137(3): 691-701, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37058425
3.
Synthetic Approaches to Piperazine-Containing Drugs Approved by FDA in the Period of 2011-2023.
Molecules
; 29(1)2023 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38202651
4.
Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators.
Molecules
; 28(3)2023 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36770942
5.
New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators.
Molecules
; 27(2)2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35056859
6.
Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities.
Pharmacol Res
; 173: 105901, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34547384
7.
Evaluating the efficiency of enzyme accelerated CO2 capture: chemical kinetics modelling for interpreting measurement results.
J Enzyme Inhib Med Chem
; 36(1): 394-401, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33430654
8.
The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.
Cereb Cortex
; 29(5): 2291-2304, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30877792
9.
Synthesis and carbonic anhydrase activating properties of a series of 2-amino-imidazolines structurally related to clonidine1.
J Enzyme Inhib Med Chem
; 35(1): 1003-1010, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32336172
10.
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers.
J Enzyme Inhib Med Chem
; 35(1): 974-992, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32253945
11.
A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer.
J Enzyme Inhib Med Chem
; 35(1): 391-397, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31865754
12.
Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells.
Molecules
; 25(7)2020 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32290281
13.
Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors.
Bioorg Chem
; 91: 103130, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31374520
14.
Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR).
Bioorg Med Chem
; 26(1): 50-64, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29162309
15.
Hyperpolarization-activated cyclic-nucleotide-gated channels: pathophysiological, developmental, and pharmacological insights into their function in cellular excitability.
Can J Physiol Pharmacol
; 96(10): 977-984, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-29969572
16.
Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators.
J Enzyme Inhib Med Chem
; 33(1): 303-308, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29280407
17.
Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents.
Bioorg Med Chem
; 25(6): 1795-1803, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28238510
18.
HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis.
J Cell Mol Med
; 19(1): 143-54, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25376115
19.
Substituted piperazines as nootropic agents: 2- or 3-phenyl derivatives structurally related to the cognition-enhancer DM235.
Bioorg Med Chem Lett
; 25(8): 1700-1704, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25813160
20.
The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation.
Eur J Pharmacol
; 966: 176329, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38253116