Detalhe da pesquisa
1.
New IDH1 mutant inhibitors for treatment of acute myeloid leukemia.
Nat Chem Biol
; 11(11): 878-86, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26436839
2.
Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors.
Bioorg Med Chem Lett
; 22(6): 2230-4, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22361133
3.
Synthesis and structure-activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent ß isoform selective phosphatidylinositol 3-kinase inhibitors.
Bioorg Med Chem Lett
; 22(9): 3198-202, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22475557
4.
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup.
Bioorg Med Chem Lett
; 21(15): 4436-40, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21733693
5.
Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
J Pharmacol Exp Ther
; 329(3): 995-1005, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19304771
6.
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
Cancer Res
; 66(23): 11100-5, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17145850
7.
Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.
ACS Med Chem Lett
; 7(3): 217-22, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985301
8.
Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation.
J Neurosci
; 24(12): 2942-52, 2004 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15044533
9.
[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase ß Inhibitors.
ACS Med Chem Lett
; 4(2): 230-4, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900655
10.
Rational Design, Synthesis, and SAR of a Novel Thiazolopyrimidinone Series of Selective PI3K-beta Inhibitors.
ACS Med Chem Lett
; 3(7): 524-9, 2012 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900504
11.
GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition.
Clin Cancer Res
; 17(5): 989-1000, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21245089
12.
An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation.
Arch Biochem Biophys
; 464(1): 130-7, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17490600
13.
Pharmacological characterization of a novel nonpeptide antagonist radioligand, (+/-)-N-[2-methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for corticotropin-releasing factor1 receptors.
J Pharmacol Exp Ther
; 305(1): 57-69, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12649353