Detalhe da pesquisa
1.
The translational landscape of mTOR signalling steers cancer initiation and metastasis.
Nature
; 485(7396): 55-61, 2012 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22367541
2.
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?
Nat Rev Immunol
; 7(3): 191-201, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17290298
3.
Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis.
Proc Natl Acad Sci U S A
; 109(4): 1251-6, 2012 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22232690
4.
Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function.
J Biol Chem
; 288(8): 5718-31, 2013 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23275335
5.
Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment.
Blood
; 120(13): 2679-89, 2012 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22826565
6.
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.
Nat Cell Biol
; 9(1): 86-91, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17173040
7.
PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis.
Am J Pathol
; 180(5): 1906-16, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22433439
8.
Defining the role of TORC1/2 in multiple myeloma.
Blood
; 118(26): 6860-70, 2011 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22045983
9.
Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models.
Breast Cancer Res Treat
; 136(3): 673-82, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23085766
10.
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
Nat Chem Biol
; 6(2): 117-24, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20081827
11.
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.
Nat Med
; 11(9): 933-5, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16127435
12.
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
Nat Med
; 11(9): 936-43, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16127437
13.
Taking PI3Kδ and PI3Kγ one step ahead: dual active PI3Kδ/γ inhibitors for the treatment of immune-mediated inflammatory diseases.
Curr Top Microbiol Immunol
; 346: 279-99, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20593311
14.
PI3K: from the bench to the clinic and back.
Curr Top Microbiol Immunol
; 347: 1-19, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20549473
15.
Functional whole-genome analysis identifies Polo-like kinase 2 and poliovirus receptor as essential for neuronal differentiation upstream of the negative regulator alphaB-crystallin.
J Biol Chem
; 284(46): 32053-65, 2009 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700763
16.
Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin.
Eur J Immunol
; 39(4): 1136-46, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19291697
17.
Chemical inducers and transcriptional markers of oligodendrocyte differentiation.
J Neurosci Res
; 88(12): 2546-57, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20544820
18.
PI3Kgamma (PI3Kgamma) is essential for efficient induction of CXCR3 on activated T cells.
Blood
; 112(8): 3048-51, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18658026
19.
Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.
Nat Rev Drug Discov
; 6(5): 391-403, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17473844
20.
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.
Circulation
; 117(10): 1310-7, 2008 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18268153