Detalhe da pesquisa
1.
Imidazole-derived agonists for the neurotensin 1 receptor.
Bioorg Med Chem Lett
; 24(1): 262-7, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24332089
2.
Synthesis and physicochemical characterization of novel phenotypic probes targeting the nuclear factor-kappa B signaling pathway.
Beilstein J Org Chem
; 9: 900-7, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23766805
3.
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.
Bioorg Med Chem Lett
; 22(21): 6656-60, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23010269
4.
Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes.
J Neurochem
; 119(3): 569-78, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21883218
5.
Exploratory analysis of kinetic solubility measurements of a small molecule library.
Bioorg Med Chem
; 19(13): 4127-34, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21640593
6.
Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells.
BMC Biol
; 8: 153, 2010 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21182779
7.
Discovery of potent inhibitors of interleukin-2 inducible T-cell kinase (ITK) through structure-based drug design.
Bioorg Med Chem Lett
; 19(3): 773-7, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19111460
8.
Isolation, synthesis, and biological activity of aphrocallistin, an adenine-substituted bromotyramine metabolite from the Hexactinellida sponge Aphrocallistes beatrix.
J Nat Prod
; 72(6): 1178-83, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19459694
9.
Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3.
Bioorg Med Chem Lett
; 18(5): 1573-6, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18242988
10.
Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3.
Bioorg Med Chem Lett
; 18(7): 2414-9, 2008 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18337097
11.
Itk kinase inhibitors: initial efforts to improve the metabolical stability and the cell activity of the benzimidazole lead.
Bioorg Med Chem Lett
; 18(20): 5537-40, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18819794
12.
5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk).
Bioorg Med Chem Lett
; 18(20): 5541-4, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18823779
13.
Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk).
Bioorg Med Chem Lett
; 18(20): 5545-9, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18819799
14.
Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett
; 8(7): 726-731, 2017 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28740606
15.
MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.
J Clin Invest
; 126(9): 3567-79, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27500491
16.
Nrf2 and HSF-1 Pathway Activation via Hydroquinone-Based Proelectrophilic Small Molecules is Regulated by Electrochemical Oxidation Potential.
ASN Neuro
; 7(4)2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26243592
17.
Recent trends in microwave-assisted synthesis.
Curr Opin Drug Discov Devel
; 5(4): 620-9, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12197320
18.
Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.
J Biomol Screen
; 19(8): 1201-11, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24870016
19.
Preparative microfluidic electrosynthesis of drug metabolites.
ACS Med Chem Lett
; 4(11): 1119-23, 2013 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900614
20.
Discovery of ML314, a Brain Penetrant Non-Peptidic ß-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.
ACS Med Chem Lett
; 4(9): 846-851, 2013 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24611085