Detalhe da pesquisa
1.
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.
Mol Microbiol
; 101(2): 194-209, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26919556
2.
Helicase-primase inhibitor pritelivir for HSV-2 infection.
N Engl J Med
; 370(3): 201-10, 2014 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24428466
3.
No Evidence of Pritelivir Resistance Among Herpes Simplex Virus Type 2 Isolates After 4 Weeks of Daily Therapy.
J Infect Dis
; 214(2): 258-64, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27056950
4.
Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial.
JAMA
; 316(23): 2495-2503, 2016 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27997653
5.
Geno- and phenotypic characterization of human cytomegalovirus mutants selected in vitro after letermovir (AIC246) exposure.
Antimicrob Agents Chemother
; 58(1): 610-3, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24189264
6.
Pharmacokinetics-pharmacodynamics of the helicase-primase inhibitor pritelivir following treatment of wild-type or pritelivir-resistant virus infection in a murine herpes simplex virus 1 infection model.
Antimicrob Agents Chemother
; 58(7): 3843-52, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24752278
7.
In vitro and in vivo activities of AIC292, a novel HIV-1 nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 57(11): 5320-9, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23959304
8.
The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections.
J Antimicrob Chemother
; 68(8): 1790-800, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23584755
9.
RNA-dependent RNA polymerases from different hepatitis C virus genotypes reveal distinct biochemical properties and drug susceptibilities.
Biochim Biophys Acta
; 1814(10): 1325-32, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21621653
10.
In vitro evaluation of the activities of the novel anticytomegalovirus compound AIC246 (letermovir) against herpesviruses and other human pathogenic viruses.
Antimicrob Agents Chemother
; 56(2): 1135-7, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22106211
11.
The novel anticytomegalovirus compound AIC246 (Letermovir) inhibits human cytomegalovirus replication through a specific antiviral mechanism that involves the viral terminase.
J Virol
; 85(20): 10884-93, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21752907
12.
Discovery, Chemistry, and Preclinical Development of Pritelivir, a Novel Treatment Option for Acyclovir-Resistant Herpes Simplex Virus Infections.
J Med Chem
; 65(20): 13614-13628, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36202389
13.
In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246.
Antimicrob Agents Chemother
; 54(3): 1290-7, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20047911
14.
Different solid forms for optimizing route of administration of the herpes drug Pritelivir.
Medchemcomm
; 10(11): 1867-1870, 2019 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32346467
15.
Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes.
Sci Transl Med
; 8(324): 324ra15, 2016 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26843190
16.
AIC649 Induces a Bi-Phasic Treatment Response in the Woodchuck Model of Chronic Hepatitis B.
PLoS One
; 10(12): e0144383, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26656974
17.
Inactivated ORF virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models.
PLoS One
; 8(9): e74605, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24066148
18.
Discovery of substituted N-phenylbenzenesulphonamides as a novel class of non-nucleoside hepatitis C virus polymerase inhibitors.
Antiviral Res
; 95(2): 182-91, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22580131
19.
Effects of therapy using a helicase-primase inhibitor (HPI) in mice infected with deliberate mixtures of wild-type HSV-1 and an HPI-resistant UL5 mutant.
Antiviral Res
; 87(1): 67-73, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20420855