Detalhe da pesquisa
1.
Integrase-LEDGF/p75 complex triggers the formation of biomolecular condensates that modulate HIV-1 integration efficiency in vitro.
J Biol Chem
; : 107374, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38762180
2.
Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Antimicrob Agents Chemother
; 67(7): e0046223, 2023 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37310224
3.
Inhibitors of UHRF1 base flipping activity showing cytotoxicity against cancer cells.
Bioorg Chem
; 137: 106616, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37247564
4.
Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75.
Nucleic Acids Res
; 49(19): 11241-11256, 2021 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34634812
5.
The HIV-1 Integrase C-Terminal Domain Induces TAR RNA Structural Changes Promoting Tat Binding.
Int J Mol Sci
; 23(22)2022 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36430221
6.
NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.
J Virol
; 94(20)2020 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32727879
7.
Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase.
Nucleic Acids Res
; 47(7): 3607-3618, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30767014
8.
Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
J Biol Chem
; 293(16): 6172-6186, 2018 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29507092
9.
A Molecular Tool Targeting the Base-Flipping Activity of Human UHRF1.
Chemistry
; 25(58): 13363-13375, 2019 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31322780
10.
DNA minicircles clarify the specific role of DNA structure on retroviral integration.
Nucleic Acids Res
; 44(16): 7830-47, 2016 09 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27439712
11.
Dynamics of Methylated Cytosine Flipping by UHRF1.
J Am Chem Soc
; 139(6): 2520-2528, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28112929
12.
Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails.
Retrovirology
; 14(1): 54, 2017 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29179726
13.
Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration.
Retrovirology
; 14(1): 39, 2017 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28754126
14.
The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.
Retrovirology
; 14(1): 50, 2017 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29121950
15.
Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine.
Biochemistry
; 54(39): 6012-20, 2015 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26368281
16.
Intasome architecture and chromatin density modulate retroviral integration into nucleosome.
Retrovirology
; 12: 13, 2015 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25807893
17.
Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.
Proc Natl Acad Sci U S A
; 109(10): E588-94, 2012 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22355136
18.
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
Retrovirology
; 10: 144, 2013 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24261564
19.
Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.
EMBO J
; 28(7): 980-91, 2009 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19229293
20.
The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton.
Cell Rep
; 42(7): 112744, 2023 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37418324