Detalhe da pesquisa
1.
Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells.
J Am Chem Soc
; 145(20): 11173-11184, 2023 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37116188
2.
6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Bioorg Med Chem Lett
; 94: 129454, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37591316
3.
Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.
Bioorg Med Chem Lett
; 92: 129394, 2023 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37379958
4.
Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.
Bioorg Med Chem Lett
; 28(23-24): 3685-3688, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30482620
5.
Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
J Biol Chem
; 291(30): 15778-87, 2016 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226591
6.
Comparative pharmacokinetic profile of cyclosporine (CsA) with a decapeptide and a linear analogue.
Org Biomol Chem
; 15(12): 2501-2506, 2017 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28266673
7.
Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.
Angew Chem Int Ed Engl
; 56(51): 16218-16222, 2017 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29073340
8.
Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes.
Drug Metab Dispos
; 44(8): 1262-9, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27079250
9.
A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.
Nat Chem Biol
; 10(8): 629-31, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24997604
10.
Improving on nature: making a cyclic heptapeptide orally bioavailable.
Angew Chem Int Ed Engl
; 53(45): 12059-63, 2014 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25219505
11.
Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling.
Biochemistry
; 52(51): 9187-201, 2013 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24320749
12.
Crystal structures of cholesteryl ester transfer protein in complex with inhibitors.
J Biol Chem
; 287(44): 37321-9, 2012 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22961980
13.
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
J Med Chem
; 66(1): 460-472, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36562986
14.
Deconstruction of activity-dependent covalent modification of heme in human neutrophil myeloperoxidase by multistage mass spectrometry (MS(4)).
Biochemistry
; 51(10): 2065-77, 2012 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22352991
15.
Insights into the novel hydrolytic mechanism of a diethyl 2-phenyl-2-(2-arylacetoxy)methyl malonate ester-based microsomal triglyceride transfer protein (MTP) inhibitor.
Chem Res Toxicol
; 25(10): 2138-52, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22989032
16.
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
J Med Chem
; 65(12): 8208-8226, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35647711
17.
Biophysical and biochemical approach to locating an inhibitor binding site on cholesteryl ester transfer protein.
Bioconjug Chem
; 19(8): 1604-13, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18646836
18.
In silico modeling of nonspecific binding to human liver microsomes.
Drug Metab Dispos
; 36(10): 2130-5, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18606744
19.
A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation.
Cell Chem Biol
; 23(11): 1362-1371, 2016 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27746128
20.
Cholesteryl ester transfer protein: pharmacological inhibition for the modulation of plasma cholesterol levels and promising target for the prevention of atherosclerosis.
Curr Top Med Chem
; 5(3): 257-64, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15857309