Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 37
Filtrar
1.
Acta Odontol Scand ; 77(1): 44-48, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30084695

RESUMO

Objective: To analyze data on occlusal traits, orthodontic treatment need and treatment complexity in orthodontically untreated 17-21-year-old Estonians.Materials and methods: Clinical records and plaster casts of 390 untreated young adults (219 females and 171 males, mean age 18.5 years, range 17-21 years) were analyzed. Assessed occlusal traits included first molar and canine sagittal relationship, overjet, overbite, crowding, midline diastema, crossbite and scissor bite. The Index of Complexity, Outcome and Need (ICON) was used to assess orthodontic treatment need and complexity. Participants' opinions regarding their teeth were determined with a questionnaire.Results: The most prevalent occlusal traits were Class I sagittal relationship in canines (76%) and molars (70%), crowding (51%), overbite ≥3.5 mm (48%), the end-to-end sagittal relationship in canines (48%) and overjet ≥3.5 mm (47%). Antero-posterior asymmetry was common both in canines (39%) and molars (37%). According to ICON, 36% of participants had orthodontic treatment need.Conclusions: Desire for orthodontic treatment was associated with crowding and increased overjet, and with no gender difference, participants' main expectation of treatment was an improvement in dentofacial aesthetics. Treatment needs determined with ICON was moderate and in line with the participants' desire for orthodontic treatment.


Assuntos
Má Oclusão/epidemiologia , Mordida Aberta/epidemiologia , Adolescente , Diastema/patologia , Estética Dentária , Estônia/epidemiologia , Feminino , Humanos , Masculino , Má Oclusão Classe I de Angle/epidemiologia , Má Oclusão Classe II de Angle/epidemiologia , Má Oclusão Classe III de Angle/epidemiologia , Adulto Jovem
2.
BMC Oral Health ; 19(1): 60, 2019 04 18.
Artigo em Inglês | MEDLINE | ID: mdl-30999906

RESUMO

BACKGROUND: Oral microbiome has significant impact on both oral and general health. Polyols have been promoted as sugar substitutes in prevention of oral diseases. We aimed to reveal the effect of candies containing erythritol, xylitol or control (sorbitol) on salivary microbiome. METHODS: Ninety children (11.3 ± 0.6 years) consumed candies during 3 years. Microbial communities were profiled using Illumina HiSeq 2000 sequencing and real-time PCR. RESULTS: The dominant phyla in saliva were Firmicutes (39.1%), Proteobacteria (26.1%), Bacteroidetes (14.7%), Actinobacteria (12%) and Fusobacteria (6%). The microbiome of erythritol group significantly differed from that of the other groups. Both erythritol and xylitol reduced the number of observed bacterial phylotypes in comparison to the control group. The relative abundance of the genera Veillonella, Streptococcus and Fusobacterium were higher while that of Bergeyella lower after erythritol intervention when comparing with control. The lowest prevalence of caries-related mutans streptococci corresponded with the lowest clinical caries markers in the erythritol group. CONCLUSIONS: Daily consumption of erythritol, xylitol or control candies has a specific influence on the salivary microbiome composition in schoolchildren. Erythritol is associated with the lowest prevalence of caries-related mutans streptococci and the lowest levels of clinical caries experience. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT01062633.


Assuntos
Cárie Dentária/prevenção & controle , Microbiota/efeitos dos fármacos , Polímeros/farmacologia , Saliva/microbiologia , Xilitol/farmacologia , Adolescente , Criança , Estônia , Humanos , Streptococcus mutans
3.
Oral Health Prev Dent ; 16(2): 153-161, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29736494

RESUMO

PURPOSE: To describe oral health behaviours and problems among elderly Vietnamese as well as determine their prevalence of caries and periodontal disease. MATERIALS AND METHODS: This cross-sectional study examined 258 elderly persons aged 65-74 years living in Danang, Vietnam. All subjects self-reported oral health behaviour and problems. Dental caries was assessed using the DMFT index. Periodontal status was evaluated with the modified Community Periodontal Index, whereby all teeth were examined for gingival bleeding and periodontal pocket depth (PPD), and the index teeth were assessed for clinical attachment loss (CAL). RESULTS: 48.4% of the elderly brushed their teeth at least twice a day; 34% had never visited a dentist; 27.8% often had difficulty chewing foods. Of the sample, mean DMFT was 14.3 ± 8.7 (DT = 6.4 ± 5.5, MT = 7.7 ± 7.1, and FT = 0.2 ± 0.9), 88.8% had untreated caries, 21.0% had at least one tooth with a PPD ≥ 6 mm, and 49.8% had at least one sextant with CAL ≥ 6 mm. The mean number of teeth per person was 22.0, of which 19.5 teeth (88.6%) had gingival bleeding, 7.7 teeth (37.1%) with a PPD 4-5 mm, and 0.8 teeth (5.0%) with a PPD ≥ 6 mm. The mean number of sextants with CAL 4-5 mm and CAL ≥ 6 mm were 2.5 ± 2.0 and 1.3 ± 1.7, respectively. Rural residence was found to be negatively associated with MT, FT, and healthy periodontal status (p < 0.05). CONCLUSIONS: Dental diseases are prevalent among elderly Vietnamese owing to a lack of awareness of oral health self-care behaviours, especially among those living in rural areas. This suggests that an oral health care programme is required to improve the oral health status of elderly Vietnamese.


Assuntos
Cárie Dentária/epidemiologia , Comportamentos Relacionados com a Saúde , Higiene Bucal , Doenças Periodontais/epidemiologia , Idoso , Estudos Transversais , Índice CPO , Feminino , Humanos , Masculino , Índice Periodontal , Prevalência , Autorrelato , Vietnã/epidemiologia
4.
BMC Oral Health ; 17(1): 147, 2017 Dec 12.
Artigo em Inglês | MEDLINE | ID: mdl-29233146

RESUMO

BACKGROUND: Apical periodontitis (AP) is an inflammatory disease around the apex of a tooth root. Reported prevalence of AP ranges from 27% to 83% while the data about most post-Soviet countries are still missing. Knowing the prevalence of AP within a certain population helps to plan the treatment need and evaluate the success of endodontic interventions. We aimed to collect data about prevalence and determining factors of AP for the first time in Estonia. METHODS: The cross-sectional study included 6552 patients (age 35.5±19.2 years). Radiographic examination was applied to investigate the prevalence of AP and quality of endodontic treatment. RESULTS: AP was diagnosed in 54.7% of subjects. Endodontically treated teeth were present in 58.2% of subjects. Periapical finding was present in 44.6% of endodontically treated and in 30.8% of untreated teeth. Out of 181,495 teeth, 52.7% were intact. AP was diagnosed in 6.3% of teeth, 6.9% of teeth were endodontically treated. Risk factors for AP included caries (OR = 2.30), male gender (OR = 1.44), too short (OR = 1.76) or too long root canal filling (OR = 2.51), root canal filling of low density (OR = 1.61) while not orthodontic appliance. Lower AP risk was associated with restoration of the tooth - filling (OR = 0.45), crown (OR = 0.34) and bridge (OR = 0.33). CONCLUSIONS: AP is highly prevalent in Southern Estonian population. Most cases are associated with root canal-treated teeth. The overall quality of root canal fillings tends to be low, consistent with the mediocre outcome of treatment. Considerable efforts are required to improve the standards of endodontic treatment.


Assuntos
Coroas , Restauração Dentária Permanente , Periodontite Periapical/epidemiologia , Obturação do Canal Radicular , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Estudos Transversais , Estônia/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Adulto Jovem
5.
Caries Res ; 50(6): 579-588, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27806364

RESUMO

OBJECTIVE: To assess the effect of daily consumption of erythritol, xylitol, and sorbitol candies on caries development in mixed dentition during a 3-year intervention and 3 years after the intervention. METHODS: 485 Estonian first- and second-grade primary school children participated. Children were randomly allocated to an erythritol, xylitol, or sorbitol (control) group. Polyol-containing candies were administered on school days with a daily polyol consumption of 3 × 2.5 g. Yearly, caries development was assessed by calibrated dentists using the ICDAS criteria. Six years after initiation of the study and 3 years after cessation of daily polyol consumption, 420 participants were re-examined to identify potential long-term effects of polyol consumption. Survival curves were generated at the end of the intervention period and 3 years after intervention. The model included age of the subjects, schools, tooth surface ages and years of surface exposure to intervention. ICDAS scoring system-based events included enamel/dentin caries development, dentin caries development, increase in caries score, and dentist intervention. RESULTS: At the end of the intervention, time to enamel/dentin caries development, dentin caries development, increase in caries score, and dentist intervention were significantly longer in the erythritol group as compared to the sorbitol group. Except for increase in caries score, all effects persisted 3 years after cessation of daily polyol consumption. CONCLUSIONS: A caries-preventive effect of 3-year erythritol consumption as compared to sorbitol was established in children with mixed dentition. The effect persisted up to 3 years after the end of the intervention.


Assuntos
Cárie Dentária/prevenção & controle , Eritritol/administração & dosagem , Sorbitol/farmacologia , Fatores Etários , Criança , Estudos de Coortes , Índice CPO , Esmalte Dentário , Dentina , Dentição Mista , Método Duplo-Cego , Feminino , Humanos , Masculino , Microbiota , Boca/microbiologia , Estudos Prospectivos , Saliva , Sorbitol/administração & dosagem , Análise de Sobrevida , Edulcorantes/administração & dosagem , Fatores de Tempo , Xilitol/administração & dosagem
6.
Caries Res ; 48(5): 482-90, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24852946

RESUMO

OBJECTIVE: The aim of this study was to test the efficacy of long-term, daily intake of erythritol and xylitol candy, compared with sorbitol candy, on the development of enamel and dentin caries lesions. METHODS: The study was a double-blind randomized controlled prospective clinical trial. Altogether 485 primary school children, first- and second-graders at baseline, from southeastern Estonia participated in this 3-year intervention. Each child consumed four erythritol, xylitol or sorbitol (control) candies three times per school day. The daily intake of polyol was about 7.5 g. The International Caries Detection and Assessment System (ICDAS) was used in the clinical examinations by four calibrated examiners at baseline and at 12, 24 and 36 months. RESULTS: The annual examination analyses and the follow-up analyses confirmed that the number of dentin caries teeth and surfaces at 24 months follow-up and surfaces at 36 months follow-up was significantly lower in the mixed dentition in the erythritol group than in the xylitol or control group. Time of enamel/dentin caries lesions to develop and of dentin caries lesions to progress was significantly longer in the erythritol group compared to the sorbitol and xylitol groups. Also the increase in caries score was lower in the erythritol group than in the other groups. CONCLUSIONS: In the follow-up examinations, a lower number of dentin caries teeth and surfaces was found in the erythritol group than in the xylitol or control groups. Time to the development of caries lesions was longest in the erythritol group. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT01062633.


Assuntos
Doces , Cariostáticos/uso terapêutico , Cárie Dentária/prevenção & controle , Eritritol/uso terapêutico , Xilitol/uso terapêutico , Criança , Índice CPO , Esmalte Dentário/efeitos dos fármacos , Dentina/efeitos dos fármacos , Dentição Mista , Progressão da Doença , Método Duplo-Cego , Feminino , Seguimentos , Humanos , Masculino , Estudos Prospectivos , Sorbitol/uso terapêutico , Fatores de Tempo , Resultado do Tratamento
7.
Oral Health Prev Dent ; 22: 115-122, 2024 02 20.
Artigo em Inglês | MEDLINE | ID: mdl-38376435

RESUMO

PURPOSE: Dental students learn knowledge and practical skills to provide oral health care to the population. Practical skills must be maintained or continuously developed throughout a professional career. This cross-sectional survey aimed to evaluate the perception of practical skills of dental students and dental-school graduates by national dental associations (NDAs) in international comparison in the European Regional Organization of the FDI World Dental Federation (ERO-FDI) zone. MATERIALS AND METHODS: A questionnaire of 14 items collected information on pre-/postgraduate areas. RESULTS: A total of 25 countries participated (response rate: 69.4%), with 80.0% having minimum requirements for practical skills acquisition and 64.0% starting practical training in the 3rd year of study. In countries where clinical practical work on patients begins in the 2nd year of study, practical skills of graduates are perceived as average, starting in the 3rd year of study as mainly good, starting in the 4th as varying widely from poor to very good. In total, 76.0% of respondents feel that improvements are needed before entering dental practice. Improvements could be reached by treating more patients in dental school (32.0%), increasing the quantity of clinical training (20.0%), or having more clinical instructors (12.0%). In 56.0% of the countries, it is possible to open one's own dental practice immediately after graduation, and in 16.0%, prior vocational training is mandatory. CONCLUSIONS: All participating countries in the ERO-FDI zone reported practical training in dental school, most starting in the 3rd year of study. The perception of practical skills of dental students and dental-school graduates among NDAs is very heterogeneous. Reasons for the perceived deficiencies should be further explored.


Assuntos
Faculdades de Odontologia , Estudantes de Odontologia , Humanos , Estudos Transversais , Europa (Continente) , Emoções
8.
Acta Odontol Scand ; 71(3-4): 410-5, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-22607272

RESUMO

OBJECTIVE: This study aims to assess the caries experience among first- and second-grade children in the elementary schools of southeastern Estonia. MATERIALS AND METHODS: A representative sample of 485 children was studied. The mean age of children in the first grade was 7.8 years (SD = 0.35) and in the second grade 8.8 years (0.38). The clinical examinations using ICDAS criteria were completed by four calibrated examiners. The inter- and intra-examiner consistency of the examiners was high (surface and tooth-based kappa >0.9). RESULTS: The mean caries experience of dentinal caries lesions was 0.8 (D 4-6 MFT) and 1.6 (D 4-6 MFS) among the first graders and 1.1 (D 4-6 MFT) and 1.6 (D 4-6 MFS) among the second graders. The mean caries enamel lesions among the first graders was 1.6 (D1-3T) and 2.2 (D1-3S) and among the second graders 2.1 and 3.0, respectively. The most affected surfaces were the occlusal surfaces of the lower first molars. The prevalence of sealants was very low-only 2.4% of the first molars were sealed among the first graders and 3.9% among the second graders. There were no statistically significant differences in caries experience or in the provision of restorative treatment between the schools. CONCLUSIONS: Caries experience is high in southeastern Estonia. Preventive programs are urgently needed.


Assuntos
Cárie Dentária/epidemiologia , Dentição Permanente , Criança , Estônia/epidemiologia , Feminino , Humanos , Masculino
9.
Birth Defects Res A Clin Mol Teratol ; 91(4): 218-25, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21462296

RESUMO

BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (CL/P) is a common complex birth defect caused by the interaction between multiple genes and environmental factors. METHODS: Five hundred and eighty-seven single nucleotide polymorphisms in 40 candidate genes related to orofacial clefting were tested for association with CL/P in a clefting sample composed of 300 patients and 606 controls from Estonian, Latvian, and Lithuanian populations. RESULTS: In case-control comparisons, the minor alleles of FGF1 rs34010 (p = 4.56 × 10(-4) ), WNT9B rs4968282 (p = 0.0013), and FOXE1 rs7860144 (p = 0.0021) were associated with a decreased risk of CL/P. Multiple haplotypes in FGF1, FOXE1, and TIMP2 and haplotypes in WNT9B, PVRL2, and LHX8 were associated with CL/P. The strongest association was found for protective haplotype rs250092/rs34010 GT in the FGF1 gene (p = 5.01 × 10(-4) ). The strongest epistatic interaction was observed between the COL2A1 and WNT3 genes. CONCLUSIONS: Our results provide for the first time evidence implicating FGF1 in the occurrence of CL/P, and support TIMP2 and WNT9B as novel loci predisposing to CL/P. We have also replicated recently reported significant associations between variants in or near FOXE1 and CL/P. It is likely that variation in FOXE1, TIMP2, and the FGF and Wnt signaling pathway genes confers susceptibility to nonsyndromic CL/P in Northeastern European populations.


Assuntos
Fenda Labial/genética , Fissura Palatina/genética , Fator 1 de Crescimento de Fibroblastos/genética , Fatores de Transcrição Forkhead/genética , Polimorfismo de Nucleotídeo Único , Inibidor Tecidual de Metaloproteinase-2/genética , Estudos de Casos e Controles , Moléculas de Adesão Celular/genética , Fenda Labial/epidemiologia , Fissura Palatina/epidemiologia , Epistasia Genética , Estônia/epidemiologia , Feminino , Loci Gênicos , Haplótipos , Proteínas de Homeodomínio/genética , Humanos , Proteínas com Homeodomínio LIM , Letônia/epidemiologia , Lituânia/epidemiologia , Masculino , Nectinas , Transdução de Sinais , Fatores de Transcrição , Proteínas Wnt/genética
10.
Clin Rheumatol ; 40(10): 4157-4165, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34101054

RESUMO

BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition of childhood. Genetic association studies have revealed several JIA susceptibility loci with the strongest effect size observed in the human leukocyte antigen (HLA) region. Genome-wide association studies have augmented the number of JIA-associated loci, particularly for non-HLA genes. The aim of this study was to identify new associations at non-HLA loci predisposing to the risk of JIA development in Estonian patients. METHODS: We performed genome-wide association analyses in an entire JIA case-control sample (All-JIA) and in a case-control sample for oligoarticular JIA, the most prevalent JIA subtype. The entire cohort was genotyped using the Illumina HumanOmniExpress BeadChip arrays. After imputation, 16,583,468 variants were analyzed in 263 cases and 6956 controls. RESULTS: We demonstrated nominal evidence of association for 12 novel non-HLA loci not previously implicated in JIA predisposition. We replicated known JIA associations in CLEC16A and VCTN1 regions in the oligoarticular JIA sample. The strongest associations in the All-JIA analysis were identified at PRKG1 (P = 2,54 × 10-6), LTBP1 (P = 9,45 × 10-6), and ELMO1 (P = 1,05 × 10-5). In the oligoarticular JIA analysis, the strongest associations were identified at NFIA (P = 5,05 × 10-6), LTBP1 (P = 9,95 × 10-6), MX1 (P = 1,65 × 10-5), and CD200R1 (P = 2,59 × 10-5). CONCLUSION: This study increases the number of known JIA risk loci and provides additional evidence for the existence of overlapping genetic risk loci between JIA and other autoimmune diseases, particularly rheumatoid arthritis. The reported loci are involved in molecular pathways of immunological relevance and likely represent genomic regions that confer susceptibility to JIA in Estonian patients. Key Points • Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease with heterogeneous presentation and genetic predisposition. • Present genome-wide association study for Estonian JIA patients is first of its kind in Northern and Northeastern Europe. • The results of the present study increase the knowledge about JIA risk loci replicating some previously described associations, so adding weight to their relevance and describing novel loci. • The study provides additional evidence for the existence of overlapping genetic risk loci between JIA and other autoimmune diseases, particularly rheumatoid arthritis.


Assuntos
Artrite Juvenil , Predisposição Genética para Doença , Artrite Juvenil/genética , Estudos de Casos e Controles , Estônia , Estudo de Associação Genômica Ampla , Humanos , Polimorfismo de Nucleotídeo Único
11.
Birth Defects Res A Clin Mol Teratol ; 88(9): 748-56, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20672350

RESUMO

BACKGROUND: Orofacial clefts are among the most common birth defects with a strong genetic component. Nonsyndromic cleft palate (NSCP) is a complex malformation determined by the interaction between multiple genes and environmental risk factors. METHODS: We conducted a case-control association study to investigate the role of 40 candidate genes in predisposition to orofacial clefting. Five hundred ninety-one haplotype tagging single nucleotide polymorphism (tagSNPs) were genotyped in a clefting sample from the Baltic region, composed of 104 patients with nonsyndromic cleft palate and 606 controls from an Estonian, Latvian, and Lithuanian population. RESULTS: In case-control comparisons, the minor alleles of IRF6 rs17389541 (p = 5.45 × 10(-4)) and COL2A1 rs1793949 (p = 7.26 × 10(-4)) were associated with increased risk of NSCP. Multiple haplotypes in COL2A1 and COL11A2 and haplotypes in WNT3, FGFR1, and CLPTM1were associated with NSCP. The strongest associations were found for IRF6 haplotype rs17389541/rs9430018 GT (p = 2.23 × 10(-4)) and COL2A1 haplotype rs12822608/rs6823 GC (p = 3.68 × 10(-4)). The strongest epistatic interactions were observed between MSX1 and BMP2, FGF1 and PVRL2, and COL2A1 and FGF2 genes. CONCLUSIONS: This study provides for the first time evidence of the implication of IRF6, COL2A1, and WNT3 in the occurrence of NSCP. It is likely that variation in cartilage collagen II and XI genes, IRF6, and the Wnt and FGF signaling pathway genes contributes susceptibility to nonsyndromic cleft palate in Northeastern European populations.


Assuntos
Fenda Labial/genética , Fissura Palatina/genética , Colágeno Tipo II/genética , Colágeno Tipo XI/genética , Fatores Reguladores de Interferon/genética , Polimorfismo de Nucleotídeo Único , Países Bálticos , Estudos de Casos e Controles , Epistasia Genética , Feminino , Regulação da Expressão Gênica no Desenvolvimento , Estudos de Associação Genética , Marcadores Genéticos , Predisposição Genética para Doença , Haplótipos , Humanos , Masculino , Fatores de Risco , Transdução de Sinais/genética
12.
Eur J Oral Sci ; 118(3): 213-20, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20572854

RESUMO

Recent studies suggest that multiple interacting loci, with possible additional environmental factors, influence the risk for nonsyndromic oral clefts, one of the most common birth defects in humans. Advances in high-throughput genotyping technology allow the testing of multiple markers, simultaneously, in many candidate genes. We tested for associations between 176 haplotype-tagging single nucleotide polymorphisms (SNPs) in 18 candidate genes/loci and nonsyndromic clefts in a case-control study in an Estonian sample (153 patients, 205 controls). The most significant associations with nonsyndromic cleft lip with or without cleft palate (CL/P) were found for SNPs in MSX1, MTHFR, and PVRL2, including several common haplotypes in the MTHFR and MSX1 genes. The strongest association was observed for rs6446693 in the MSX1 region, which remained statistically significant after Bonferroni correction. The strongest association with nonsyndromic cleft palate (CP) was found for the SNP rs11624283 in the JAG2 gene. Epistatic interactions were observed for SNPs within PVRL2, between BCL3 and EDN1, and between IRF6 and MSX1 genes. This study provides further evidence implicating MSX1 and MTHFR in the etiology of nonsyndromic CL/P across different populations.


Assuntos
Fenda Labial/etiologia , Fissura Palatina/etiologia , Fator de Transcrição MSX1/genética , Metilenotetra-Hidrofolato Redutase (NADPH2)/genética , Adenina , Proteína 3 do Linfoma de Células B , Estudos de Casos e Controles , Moléculas de Adesão Celular/genética , Mapeamento Cromossômico , Fenda Labial/genética , Fissura Palatina/genética , Citosina , Endotelina-1/genética , Epistasia Genética/genética , Estônia , Frequência do Gene/genética , Guanina , Haplótipos/genética , Humanos , Imunoglobulinas/genética , Peptídeos e Proteínas de Sinalização Intercelular/genética , Fatores Reguladores de Interferon/genética , Proteína Jagged-2 , Proteínas de Membrana/genética , Nectinas , Polimorfismo de Nucleotídeo Único/genética , Proteínas Proto-Oncogênicas/genética , Fatores de Risco , Timina , Fatores de Transcrição/genética
13.
Eur J Oral Sci ; 118(3): 317-9, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20572868

RESUMO

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common birth defects and has a multifactorial etiology that includes both genetic and environmental factors. Recently, two novel susceptibility loci and three suggestive loci for NSCL/P were identified by a genome-wide association scan (GWAS) in a German population with subsequent independent replication in a mixed European population. The aim of the present study was to investigate whether these newly detected loci confer similar effects in the North-East European Baltic population. A total of 101 NSCL/P patients and 254 controls from Estonia were included. A significant association was observed for rs7078160 (P = 0.0016) at chromosome 10q25, which confirms the association of this locus with NSCL/P in the Baltic population. No significant association was found for the other four loci, a result that may have been attributable to the limited power of the sample.


Assuntos
Mapeamento Cromossômico , Cromossomos Humanos Par 10/genética , Fenda Labial/genética , Fissura Palatina/genética , Predisposição Genética para Doença/genética , Adenina , Estudos de Casos e Controles , Citosina , Estônia , Feminino , Frequência do Gene/genética , Genótipo , Guanina , Heterozigoto , Homozigoto , Humanos , Masculino , Polimorfismo de Nucleotídeo Único/genética , Fatores de Risco , Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz , Timina
14.
Int J Paediatr Dent ; 20(1): 24-30, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20059590

RESUMO

INTRODUCTION: It is well established that severe periodontitis clusters in families, but there are no data about the relationship between mothers with chronic periodontitis and their children's periodontal status. OBJECTIVE: To evaluate a risk for periodontal diseases in children of periodontally diseased and healthy mothers. METHODS: Four study groups were included: (I) 20 female patients with untreated generalized severe chronic periodontitis, (II) their children (34), (III) 13 periodontally healthy mothers and (IV) their children (13). Material was collected from years 2004-2006. The clinical examination included registration of visible plaque index, modified gingival index and, bleeding sites on probing. Periodontal microbiological samples were obtained from all study subjects and the isolates were identified according to morphology and biochemical profiles; similar interfamilial pathogens were compared by PCR-technique. RESULTS: The children of diseased mothers more frequently had periodontal diseases, especially gingivitis. In addition, clinical parameters of gingival inflammation were more expressed and oral hygiene was worse in this group of children. VPI and VPI% of the diseased and healthy mothers differed significantly. The most common oral pathogens were P. intermedia/nigrescens and A. actinomycetemcomitans. The children of healthy mothers harboured pathogens less frequently than the children of diseased mothers. The sharing of P. intermedia/nigrescens was more frequent (5 families) than A. actinomycetemcomitans (2 families). CONCLUSION: Maternal indicators, such as periodontitis, hygiene habits, and periodontal microflora are risk factors for childhood periodontal diseases, and might be predictive of future childhood and adolescent periodontitis.


Assuntos
Periodontite Crônica/classificação , Relações Mãe-Filho , Adolescente , Adulto , Aggregatibacter actinomycetemcomitans/isolamento & purificação , Criança , Pré-Escolar , Periodontite Crônica/microbiologia , Contagem de Colônia Microbiana , Índice de Placa Dentária , Feminino , Hemorragia Gengival/classificação , Hemorragia Gengival/microbiologia , Gengivite/classificação , Gengivite/microbiologia , Humanos , Masculino , Boca/microbiologia , Higiene Bucal , Índice Periodontal , Periodontite/classificação , Periodontite/microbiologia , Prevotella intermedia/isolamento & purificação , Prevotella nigrescens/isolamento & purificação , Medição de Risco , Fatores de Risco
15.
Stomatologija ; 12(4): 105-8, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21266834

RESUMO

OBJECTIVES: To study epidemiological factors causing development of cleft lip and palate and their occurrence regularities. MATERIALS AND METHODS: This study included 583 cleft lip and palate patients and the information for statistical analyses was gathered from Tartu University Hospital. RESULTS: 19% of the patients had a cleft lip (CL), 39% of the patients had a cleft palate (CP), and 42 % of the patients had a cleft lip and palate (CLP). The ratio for different cleft types CL: CLP: CP was 1:2:2. In unilateral CLP and CL cases, the left side was affected 2.2 times more frequently than the right side. Boys had a CLP nearly 2.1 times more often than girls. CP was more common for girls (60%) than for boys (40%). 30% of children had multiple malformations. 2.6% of children with clefts were born premature, half of which had accompanying developmental anomalies. The average birth weight for cleft child was ~3400 grams. 6.8% of children with clefts had a birth weight below 2.5 kg. In case of children with clefts, the mother's age exceeded 30 years in 1/4 of cases and father's age in 1/3 of cases. Both parents were older than 30 years in 66% of the cases. 1/5 of both parents were older than 30 years. 1/3 of mothers of children with clefts had suffered psychological stress, 1/5 of mothers had done hard physical work. 1/5 of mothers had an exposure to teratogenic toxic substances. 15% of them received medications during the first trimester of pregnancy. 15% of mothers had experienced hormonal disorders. CONCLUSIONS: As a result of the study we found a high occurrence rate of CP (CL: CLP: CP--1:2:2), which is similar to the studies conducted in Finland and Sweden. The reasons for this ratio need further research.


Assuntos
Fenda Labial/epidemiologia , Fissura Palatina/epidemiologia , Anormalidades Múltiplas/epidemiologia , Adulto , Peso ao Nascer , Doenças do Sistema Endócrino/epidemiologia , Estudos Epidemiológicos , Estônia/epidemiologia , Feminino , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido , Masculino , Idade Materna , Exposição Materna/estatística & dados numéricos , Ocupações/estatística & dados numéricos , Idade Paterna , Gravidez , Nascimento Prematuro/epidemiologia , Efeitos Tardios da Exposição Pré-Natal/epidemiologia , Prevalência , Fatores Sexuais , Estresse Psicológico/epidemiologia , Teratogênicos
16.
Clin Exp Dent Res ; 5(3): 199-204, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31249699

RESUMO

This study aims to evaluate the prevalence of occlusal traits and to assess parents'/caregivers' satisfaction with child's dental appearance and perception of orthodontic treatment need in 4-5-year-old Estonians. Clinical records and plaster casts of 390 children (190 girls and 200 boys, mean age 4.7 years, range 4 - 5 years) were analyzed. Assessed occlusal traits included deciduous canine and second molar sagittal relationship, overjet, overbite, crowding, midline diastema, crossbite, and scissor bite. Parents'/caregivers' opinions regarding their child's teeth were determined with a questionnaire. The most prevalent occlusal traits were symmetrical sagittal relationship in deciduous canines (78.2%) and molars (75.1%), Class I sagittal relationship in deciduous canines (69.7%) and midline diastema (67.7%). Asymmetrical sagittal canine relationship was registered in 21.8% deciduous canines and in 24.9% second deciduous molars. Parents'/caregivers' perceived orthodontic treatment need was related to Class III sagittal relationship in canines, increased overjet and overbite, negative overbite, and crossbite. Prevalence of most occlusal traits in Estonian children were in line with those reported in neighboring countries. Parents/caregivers were well able to observe occlusal traits that deviated from acceptable occlusion.


Assuntos
Má Oclusão/fisiopatologia , Ortodontia Corretiva , Pais , Satisfação Pessoal , Aparência Física , Pré-Escolar , Estônia , Feminino , Humanos , Índice de Necessidade de Tratamento Ortodôntico , Masculino , Má Oclusão/terapia , Má Oclusão Classe I de Angle/fisiopatologia , Má Oclusão Classe I de Angle/terapia , Má Oclusão Classe II de Angle/fisiopatologia , Má Oclusão Classe II de Angle/terapia , Má Oclusão Classe III de Angle/fisiopatologia , Má Oclusão Classe III de Angle/terapia , Avaliação das Necessidades , Sobremordida/fisiopatologia , Sobremordida/terapia
17.
J Maxillofac Oral Surg ; 17(3): 362-371, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30034156

RESUMO

OBJECTIVE: The aim of study was to determine the association between signs of temporomandibular disorders (TMD), occlusal support, and alterations in the craniofacial structure of elderly Vietnamese by using cephalometric analysis. METHODS: The cross-sectional study consisted of 244 participants aged 65-74 years. Participants were examined for signs of TMD, including limited mouth opening, temporomandibular joint (TMJ) crepitus, TMJ tenderness, and muscle tenderness. Dentition was divided into four occlusal support zones based on occluding pairs of posterior teeth by using Eichner's classification: Class A = 4 support zones; Class B = 1-3 support zones or only contact in anterior teeth; Class C = 0 support zones. Fifteen angular and seven linear parameters were used for sagittal craniofacial skeleton analysis. RESULTS: 10.3% of participants had limited mouth opening, 49.6% TMJ crepitus, 16.3% TMJ tenderness, and 24.2% muscle tenderness; 45.5% had Class A occlusal support, 38.5% Class B, and 16.0% Class C. Those with Class C had significantly smaller ramus inclination, articular angle, and angles formed by the mandibular plane and shorter facial height compared to Class A and Class B (P < .001). TMD signs were significantly associated with: angles formed by mandibular plane, gonial angle, cranial base angle, effective mandibular length, and anterior facial height (P < .05). CONCLUSIONS: The alteration of craniofacial structures was significantly associated with TMD signs among elderly Vietnamese. The higher number of lost occlusal support zones, the more significant the changes to craniofacial structures.

18.
Clin Exp Dent Res ; 4(5): 182-188, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30386640

RESUMO

Dental fear and anxiety (DFA) has the impact on the development of dental caries. Ethnic background and oral health care system may contribute to DFA model. The aim of the study was to compare DFA in relation to dental health between Estonian and Vietnamese schoolchildren and to determine DFA cutoff point for schoolchildren of two countries. The sample comprised 900 schoolchildren (344 from Estonia and 556 from Vietnam). DFA was measured by using 11 fear items of the modified Dental Subscale of the Children's Fear Survey Schedule (CFSS-DS). Dental health was recorded by using the dental caries experience index of mixed dentition (dmft/DMFT). Results showed that the mean score of dmft/DMFT in Estonian and Vietnamese schoolchildren was 5.2 ± 3.1 and 4.1 ± 3.2, respectively. The mean score of 11-item CFSS-DS of Vietnamese schoolchildren (20.8 ± 9.1) was significantly higher compared with Estonian schoolchildren (15.4 ± 4.4, p < 0.001). The DFA cutoff point of 11-item CFSS-DS in Estonian schoolchildren was 17.5, whereas in Vietnamese, it was 24.5. The lower ranking of DFA was significantly associated with Estonian schoolchildren who had more FT (p < 0.001). In conclusion, the level of DFA of schoolchildren was different in Estonia and Vietnam. Vietnamese schoolchildren had higher DFA scores and cutoff point of the modified CFSS-DS than Estonian schoolchildren. The obtained results suggest that DFA in schoolchildren can be related to oral health care system of each country.

19.
EPMA J ; 9(2): 187-193, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29896317

RESUMO

OBJECTIVE: The study aims to investigate how mothers' oral health behaviour and perception thereof influence the dental health in their children. METHODS: A total of 556 Vietnamese mother-child pairs participated in the current study. Mothers self-reported their oral status and oral health behaviour and perception. Dental caries of the children were examined using the index of decayed, missing, and filled teeth. The Dental Anxiety Scale instrument was used to assess the dental anxiety level in mothers and children. RESULTS: Among mothers, 41.3% had gingival bleeding, 40% perceived their dentition and gingival status to be at a good level, 68% brushed their teeth more than twice a day, and 17% had never visited a dentist. Mothers' oral health behaviour and their perception thereof were positively correlated with their frequency of dental visits (r = (0.105-0.221), p < 0.001) and negatively correlated with dental anxiety (r = (- 0.149- - 0.105), p < 0.05).Caries-free children were positively correlated with mothers having more than 20 teeth (r = 0.085, p < 0.05). Positive correlations between mothers and children were found in terms of frequency of fresh fruits consumption (r = 0.090, p < 0.05), drinking sweet beverages (r = 0.072, p < 0.05), and dental anxiety (r = 0.183, p < 0.001). CONCLUSIONS: Maternal oral health was significantly associated with dental health of their children. Not only did maternal dental anxiety influence oral health of mothers but it was also a concomitant factor in the development of children's dental anxiety. The education programme on mothers' oral health-related knowledge can be a target for improvement of the oral health of mothers and children.

20.
Int J Prosthodont ; 30(5): 465­470, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28750108

RESUMO

PURPOSE: The aim of this study was to analyze the associations between missing teeth, occlusal support, and temporomandibular disorders (TMD) among elderly Vietnamese. MATERIALS AND METHODS: The study consisted of 145 TMD and 112 non-TMD (control group) participants aged 65 to 74 years. TMD was evaluated using Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Axis I. An occlusal unit (OU) was defined as the cusp of a tooth coupled with the fossa of its antagonist tooth. A premolar pair was counted as one OU and a molar pair as two OUs. Dentition was divided into four occlusal support zones (OSZs) based on occluding pairs of posterior teeth by using Eichner classification: Class A had 4 OSZs, Class B had 1 to 3 OSZs or only anterior teeth, and Class C had no OSZ. RESULTS: The TMD group lost significantly more posterior teeth (mean ± SD 5.1 ± 4.7) than the control group (4.0 ± 3.9, P = .033). The mean ± SD OUs of the TMD and control groups were 5.1 ± 4.6 and 6.0 ± 4.3, respectively, which was nonsignificant (NS). The distribution of Class A (40.7%), Class B (40.0%), and Class C (19.3%) among the TMD group was not significantly different from the control group (50.0%, 38.4%, and 11.6%, respectively, NS). The odds of having TMD were positively associated with total unilateral loss of OUs (OR = 3.4, 95% CI = 1.2-9.4, P = .020) and total bilateral loss of OUs (OR = 2.7, 95% CI = 1.2-6.6, P = .027). CONCLUSION: Total loss of OSZs on one or both sides of the mouth were found to be predictors of TMD among elderly Vietnamese.


Assuntos
Oclusão Dentária , Transtornos da Articulação Temporomandibular/etiologia , Perda de Dente/complicações , Idoso , Povo Asiático , Estudos Transversais , Feminino , Humanos , Masculino
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA