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BACKGROUND: The stenosis of the coronary arteries is usually caused by atherosclerosis. Hemodynamic significance of patient-specific coronary stenoses and the risk of its progression may be assessed by comparing the hemodynamic effects induced by flow disorders. The present study shows how stenosis degree and variable flow conditions in coronary artery affect the oscillating shear index, residence time index, pressure drop coefficient and fractional flow reserve. We assume that changes in the hemodynamic indices in relation to variable flow conditions and geometries evaluated using the computational fluid dynamics may be an additional factor for a non-invasive assessment of the coronary stenosis detected on multi-slice computed tomography. METHODS: The local-parametrised models of basic shapes of the vessels, such as straight section, bend, and bifurcation as well as the global-patient-specific models of left coronary artery were used for numerical simulation of flow in virtually reconstructed stenotic vessels. Calculations were carried out for vessels both without stenosis, and vessels of 10 to 95% stenosis. The flow rate varied within the range of 20 to 1000 ml/min, and heart rate frequency within the range of 30 to 210 cycles/min. The computational fluid dynamics based on the finite elements method verified by the experimental measurements of the velocity profiles was used to analyse blood flow in the coronary arteries. RESULTS: The results confirm our preliminary assumptions. There is significant variation in the coronary hemodynamic indices value caused by disturbed flow through stenosis in relation to variable flow conditions and geometry of vessels. CONCLUSION: Variations of selected hemodynamic indexes induced by change of flow rate, heart rate and vessel geometry, obtained during a non-invasive study, may assist in evaluating the risk of stenosis progression and in carrying out the assessment of the hemodynamic significance of coronary stenosis. However, for a more accurate assessment of the variability of indices and coronary stenosis severity both local (near the narrowing) and global (in side branches) studies should be used.
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Angiografia por Tomografia Computadorizada , Angiografia Coronária/métodos , Circulação Coronária , Estenose Coronária/diagnóstico por imagem , Estenose Coronária/fisiopatologia , Vasos Coronários/diagnóstico por imagem , Vasos Coronários/fisiopatologia , Frequência Cardíaca , Tomografia Computadorizada Multidetectores , Modelagem Computacional Específica para o Paciente , Velocidade do Fluxo Sanguíneo , Humanos , Modelos Cardiovasculares , Análise Numérica Assistida por Computador , Valor Preditivo dos Testes , Interpretação de Imagem Radiográfica Assistida por Computador , Fluxo Sanguíneo Regional , Índice de Gravidade de DoençaRESUMO
AIM OF THE STUDY: To present the most popular types of tattoos, their meaning and classification, and to assess the suitability of different forms of tattoos in the process of identification of corpses of unknown identity. MATERIAL AND METHODS: The tattoos found on 729 cadavers who underwent post mortem examinations at the Department of Forensic Medicine in Warsaw in the years 2012-2015 were analyzed. The tattoos were photographed and identified in terms of their meaning domain and classified into groups. RESULTS: Tattoos belonging to all groups were found, according to the most popular tattoo classification, which is based on their nature and includes: criminal and prison tattoos (defining the prison hierarchy, criminal profession as well as intentions and goals, erotic tattoos, environmental, penitentiary), military and artistic. The novel classification, focusing on the utility of certain kinds of tattoos for identyfying corpses of unknown identity, was also developed. According to the above mentioned classification the following kinds of tattoos are distinguished: individual (artistic), group (e.g. penitentiary - indicating the fact of being imprisoned in a penitentiary institution or belonging to a "prison kites" subculture, or presenting criminal profession; group confined tattoo (indicating a staying in a specific penitentiary institution), group tattoo with individual data (indicating the fact of staying in a penitentiary institution as well as dates of imprisonment), and others (e.g. names of relatives, military tattoo, etc.). CONCLUSIONS: Analysis of individual types of tattoo can accelerate the process of identification of the cadavers. The proposed classification allows to quickly determine whether a particular tattoo can be helpful in initial individual identification (in the case of individual tattoos) or whether it can be used to reduce the group of people considered (in cases of different types of group tattoos).
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Autopsia , Criminosos , Antropologia Forense/métodos , Tatuagem , Cadáver , HumanosRESUMO
The Polish ventricular assist device (Polvad) has been used successfully in clinical contexts for many years. The device contains two single-disc valves, one at the inlet and one at the outlet connector of the pneumatic pump. Unfortunately, in recent years, a problem has occurred with the availability of single-disc valves. This article presents the possibility of using bileaflet mechanical heart valve prostheses in the Polvad to avoid a discontinuity in clinical use. The study is based on experimental and numerical simulations and comparison of the distribution of flow, pressure, and stress (wall, shear, and turbulent) inside the Polvad chamber and the inlet/outlet connectors fitted with Sorin Monodisc and Sorin Bicarbon Fitline valves. The type and orientation of the inlet valve affects valve performance and flow distribution inside the chamber. Near-wall flow is observed for single-disc valves. In the case of bileaflet valves, the main jet is directed more centrally, with lower shear stress but higher turbulent stress in comparison with single-disc valves. For clinical usage, a 45° orientation of the bileaflet inlet valve was chosen, as this achieves good washing of the inlet area near the membrane paste surface. The Polvad with bileaflet valves has now been used successfully in our clinic for over a year and will continue to be used until new assist devices for heart support are developed.
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Próteses Valvulares Cardíacas , Adulto , Simulação por Computador , Hemodinâmica , Humanos , Pessoa de Meia-Idade , Modelos Cardiovasculares , Polônia , Pressão , Desenho de Prótese , Fluxo Pulsátil , Estresse MecânicoRESUMO
UNLABELLED: The purpose of this study was to determine expectations of public prosecutors towards forensic professionals participating in external examinations of dead bodies performed at the site of finding the corpses. The presence of forensic physicians on the crime scene was recognized as advantageous by all prosecutors; however, expectations associated with corpse inspection did not correspond to capabilities of modern medicine or necessitated repeating activities performed during autopsies. Homicides (99%), deaths of children (86%) and "media" deaths (73%) were indicated as cases when the presence of forensic professional was especially important. Definition of injuries with indication of the causative object made by forensic physicians on the crime scene was the advantage most often chosen by respondents (82%). Almost one third of respondents expected forensic physicians to evaluate the length and direction of wound tracts, more than half of them--to provide a detailed description of injuries, one fifth wanted physicians to determine the exact time of death. Description of post mortem changes was not indicated as the most important benefit by any prosecutor. CONCLUSIONS: Public prosecutors recognized the presence of forensic professionals on the crime scene as advantageous, but their expectations associated with dead body examinations did not correspond to capabilities of forensic medicine or forced physicians to perform activities normally made during autopsy. An algorithm of dead body examination on the crime scene including aims and advantages of such a examination should be developed jointly by prosecutors and forensic medicine specialists.
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Crime/estatística & dados numéricos , Prova Pericial , Medicina Legal/organização & administração , Exame Físico/estatística & dados numéricos , Autopsia/estatística & dados numéricos , Direito Penal/organização & administração , Humanos , Meios de Comunicação de Massa/estatística & dados numéricos , Patologia Clínica/organização & administração , Polônia , Mudanças Depois da Morte , Opinião Pública , Manejo de Espécimes/estatística & dados numéricosRESUMO
Purpose: Drownings are a societal phenomenon occurring worldwide, hence the importance of rescue skills, including directly towing a victim to a safe place. The purpose of this study was to evaluate the most effective towing techniques based on kinematic parameters, considering different types of drowning cases, for their recommendation for widespread use in water rescue. Methods: The research involved 18 water lifeguards aged 18-25 years. The evaluation included speed tests in towing a mannequin over a distance of 50 m using the Extended Arm Tow (EAT), Double Armpit Tow (DAT), "Sailor" Technique Tow (STT) and with a rescue tube (RT), accompanied by video recording to measure in the designated measurement area the number of cyclic paddling movements by the lower limbs, angles of the body attack, towing velocity, and its decrease during towing. Results: Number of cyclic paddling movements by the lower limbs, towing with a RT was considered the most beneficial, and least beneficial was the DAT. In the DAT, the lifeguard swam with the smallest body angle, in contrast to the STT, where this angle was the largest. The effect of the number of cyclic paddling movements and the body angle by the lifeguard was the velocity, with the highest value recorded in towing using a RT; in other techniques, velocity were similar. Conclusions: Institutions associated with water rescue should recommend towing using a RT for direct rescue actions in the water, as its use shortens the time, while simultaneously increasing safety for both the rescuer and the victim.
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Trabalho de Resgate , Humanos , Adulto , Adulto Jovem , Trabalho de Resgate/métodos , Adolescente , Água , Masculino , Fenômenos Biomecânicos , Feminino , Afogamento/prevenção & controle , ManequinsRESUMO
Formation of plasmonically active silver, copper and composite silver-copper nanostructures were studied in this paper. Metallic nanostructures were fabricated by thermal disintegration, so called dewetting, of the thin films in an argon atmosphere. The formation process of the nanostructures was in-situ observed by a novel method, based on resistance measurements. The influence of the material and thickness of the initial thin film on temperature of their disintegration was investigated. Electrical measurements were validated by scanning electron microscopy observations, while metallic the behavior of nanostructures was studied by XPS method. The formation of silver-copper nanocomposite structures was confirmed by UV-vis spectroscopy. Plasmon resonance with two characteristic peaks for nanocomposite structures was observed.
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PURPOSE: An important aspect in the prevention and treatment of coronary artery disease is the functional evaluation of narrowed blood vessels. Medical image-based Computational Fluid Dynamic methods are currently increasingly being used in the clinical setting for flow studies of cardio vascular system. The aim of our study was to confirm the feasibility and functionality of a non-invasive computational method providing information about hemodynamic significance of coronary stenosis. METHODS: A comparative method was used to simulate the flow energy losses in real (stenotic) and reconstructed models without (reference) stenosis of the coronary arteries under stress test conditions, i.e. for maximum blood flow and minimal, constant vascular resistance. In addition to the absolute pressure drop in the stenotic arteries (FFRsten) and in the reconstructed arteries (FFRrec), a new energy flow reference index (EFR) was also defined, which expresses the total pressure changes caused by stenosis in relation to the pressure changes in normal coronary arteries, which also allows a separate assessment of the haemodynamic significance of the atherosclerotic lesion itself. The article presents the results obtained from flow simulations in coronary arteries, reconstructed on the basis of 3D segmentation of cardiac CT images of 25 patients from retrospective data collection, with different degrees of stenoses and different areas of their occurrence. RESULTS: The greater the degree of narrowing of the vessel, the greater drop of flow energy. Each parameter introduces an additional diagnostic value. In contrast to FFRsten, the EFR indices that are calculated on the basis of a comparison of stenosed and reconstructed models, are associated directly with localization, shape and geometry of stenosis only. Both FFRsten and EFR showed very significant positive correlation (P < 0.0001) with coronary CT angiography-derived FFR, with a correlation coefficient of 0.8805 and 0.9011 respectively. CONCLUSION: The study presented promising results of non-invasive, comparative test to support of prevention of coronary disease and functional evaluation of stenosed vessels.
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Doença da Artéria Coronariana , Estenose Coronária , Reserva Fracionada de Fluxo Miocárdico , Humanos , Angiografia por Tomografia Computadorizada , Constrição Patológica , Estudos Retrospectivos , Doença da Artéria Coronariana/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Angiografia Coronária/métodos , Hemodinâmica , Vasos Coronários/diagnóstico por imagemRESUMO
This study aims to evaluate the effects of a prolonged transition period (detraining) on the physical capacity, power, and speed parameters of elite swimmers. Fourteen swimmers (seven females and seven males) aged 20.4 ± 1.7 years participated in the study. The athletes were subjected to two rounds of identical tests at 12-week intervals during the detraining period (DP), which consisted of an evaluation of the athletes' body weight and composition, a measurement of the power of their lower limbs (Keiser squat, countermovement jump (CMJ), akimbo countermovement jump (ACMJ)) and upper limbs (Keiser arms) on land, and 20-m swimming using the legs only (Crawl Legs test), arms only (Crawl Arms test), and full stroke (Front Crawl test). An analysis of variance revealed a significant effect of the main factor, Gender, on all the measured parameters, while for the factor Detraining, except for Front Crawl (W) (F = 4.27, p = 0.061), no significant interaction effect (Gender × Detraining) was revealed. Among both the male and the female participants, a reduction in lactate-threshold swimming speed (LT Dmax) and a reduction in swimming speed and power on the Crawl Arms, Crawl Legs, and Front Crawl tests was observed after 12 weeks. There were also statistically significant reductions in ACMJ and CMJ jump height and upper-limb power (Keiser squat) among the female and male swimmers. There were no significant changes in body weight or body composition. The study showed a clear deterioration in results for most of the parameters, both for those measured on land and for those measured in water.
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Braço , Natação , Atletas , Peso Corporal , Feminino , Humanos , Perna (Membro) , MasculinoRESUMO
The purpose of this study was to examine the relationship between a unique complex of predictors and 100 m front crawl race kinematics and swimming speed. In 28 male competitive swimmers (age: 19.6 ± 2.59 years), the following groups of predictors were assessed: (a) the morphologic, (b) the functional upper limb range of motion, and (c) the anaerobic indices of arm-cranking and a series of countermovement jumps. The Pearson product-moment correlation coefficient was calculated to distinguish the predictors and the swimming results. The main finding was that the indices of the power (arm-cranking) and the work (countermovement jump) generated in the anaerobic tests showed a significant and higher correlation with stroke length and stroke index than total body length, upper limb range of motion, or hand and forearm surface area. These results were obtained in accordance with the high swimming economy index relation to clear surface swimming speed. This study reveals that the strength generated by the limbs may represent a predictor of swimming kinematics in a 100 m front crawl performance.
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Natação , Extremidade Superior , Adolescente , Adulto , Anaerobiose , Fenômenos Biomecânicos , Feminino , Humanos , Masculino , Adulto JovemRESUMO
In this work we study the luminescence properties of europium-doped titanium dioxide and tellurium oxide thin films enhanced by gold plasmonic nanostructures. We propose a new type of plasmon structure with an ultrathin dielectric film between plasmonic platform and luminescent material. Plasmonic platforms were manufactured through thermal annealing of the gold thin film. Thermal dewetting of gold film results in spherical gold nanostructures with average dimensions of 50 nm. Both, luminescent TiO2:Eu and TeO2:Eu films were deposited by RF magnetron sputtering from mosaic targets. The morphology of the gold nanostructures was investigated by SEM and TEM, while the composition of oxides film was analyzed by XPS. Luminescence properties were studied on the basis of excitation and emission spectra. The experiments show that the additional dielectric layer enhances the luminescence intensity. Such structures could be potential candidates as phosphors in white LEDs.
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Glass-ceramics with the composition B2O3-Bi2O3-SrF2 were synthesized by the conventional melt-quenching technique and subsequent crystallization of the parental glasses. The temperature at which the ceramization was carried out was selected based on differential scanning calorimetry (DSC) analysis. The structure of the studied materials and the formation of SrF2 nanocrystals were confirmed by the Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) techniques. It was found that the amount of strontium fluoride introduced into the parental borate-bismuth glass has a significant impact on the growth of SrF2 nanocrystals. In particular, the influence of the crystalline SrF2 phase on luminescence intensity and kinetics was studied using Eu2O3-doped samples. An increase in luminescence intensity was observed in the samples in which SrF2 nanocrystals were formed. This is most likely related to the fact that some of the Eu3+ ions were (after annealing of the glass) located in the crystalline structure of strontium fluoride. This was confirmed both by the luminescence lifetime obtained based on the luminescence decay curves and the calculated Judd-Ofelt parameters, Ω2 and Ω4. The results achieved confirm that the glasses and glass-ceramics described in this work could be considered as a new phosphor for light-emitting diodes (LEDs).
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BACKGROUND: 3D bioprinting is the future of constructing functional organs. Creating a bioactive scaffold with pancreatic islets presents many challenges. The aim of this paper is to assess how the 3D bioprinting process affects islet viability. METHODS: The BioX 3D printer (Cellink), 600 µm inner diameter nozzles, and 3% (w/v) alginate cell carrier solution were used with rat, porcine, and human pancreatic islets. Islets were divided into a control group (culture medium) and 6 experimental groups (each subjected to specific pressure between 15 and 100 kPa). FDA/PI staining was performed to assess the viability of islets. Analogous studies were carried out on α-cells, ß-cells, fibroblasts, and endothelial cells. RESULTS: Viability of human pancreatic islets was as follows: 92% for alginate-based control and 94%, 90%, 74%, 48%, 61%, and 59% for 15, 25, 30, 50, 75, and 100 kPa, respectively. Statistically significant differences were observed between control and 50, 75, and 100 kPa, respectively. Similar observations were made for porcine and rat islets. CONCLUSIONS: Optimal pressure during 3D bioprinting with pancreatic islets by the extrusion method should be lower than 30 kPa while using 3% (w/v) alginate as a carrier.
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The aim of this study was to assess the impact of a 6-week specialized training program aimed at strengthening core muscles to improve the effectiveness of selected elements of a swimming race on a group of Polish swimmers. Sixteen male national level swimmers (21.6 ± 2.2 years) participated in the research. The competitors were randomly assigned to 1 of 2 groups before the data collection process: an experimental (EG, n = 8) and a control (CG, n = 8) group. Both groups of swimmers underwent the same training program in the water environment (volume and intensity), while swimmers from the EG additionally performed specific core muscle training. The task of the swimmers was an individual front crawl swim of 50 m, during which the kinematic parameters of the start jump, turn and swimming techniques were recorded using a video camera system. In both groups, a minor increase in the flight phase was observed at the start (EG = 0.06 m, 1.8%; p = 0.088; CG = 0.08 m, 2.7%; p = 0.013). The time to cover a distance of 5 m after the turn and the recorded average speed in swimming this distance for the EG statistically significantly improved by 0.1 s (-28.6%; p < 0.001) and 3.56 mâs-1 (23.2%; p = 0.001), respectively. In the EG, a statistically significant improvement in 50 m front crawl swimming performance of 0.3 s (-1.2%, p = 0.001) was observed. The results of the research show that the implementation of isolated strengthening of the stabilizing muscles seems to be a valuable addition to the standard training of swimmers.
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Exercício Físico/fisiologia , Condicionamento Físico Humano/métodos , Natação/fisiologia , Desempenho Atlético/fisiologia , Fenômenos Biomecânicos , Terapia por Exercício , Humanos , Masculino , Força Muscular/fisiologia , Músculos , Polônia , Treinamento Resistido/métodos , Adulto JovemRESUMO
We demonstrate that a GaN nanowire array can be used for efficient charge transfer between the organic photovoltaic layer and silicon in a Si/GaN/P3HT:PC71BM inverted hybrid heterostructure. The band alignment of such a material combination is favorable to facilitate exciton dissociation, carrier separation and electron transport into Si. The ordered nature of the GaN array helps to mitigate the intrinsic performance limitations of the organic active layer. The dependence of photovoltaic performance enhancement on the morphology of the nanostructure with nanowire diameters 30, 50, 60, 100 and 150 nm was studied in detail. The short circuit current was enhanced by a factor of 4.25, while an open circuit voltage increase by 0.32 volts was achieved compared to similar planar layers.
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PURPOSE: The purpose of this research was to examine the impact of body composition on the anaerobic ability to generate strength and power produced separately by upper and lower limbs during dry-land and in-water (propulsion force) tests. Further examination included the influence of all gathered anaerobic strength indices on the results of 100-m front crawl race. METHODS: The study involved 26 male swimmers (age: 19.8 ± 2.48 years). Fat-free mass, total body water and muscle mass of arms, legs, and trunk were measured. Dry-land average work, maximal power generated in 40-second arm-cranking test, and work generated in 20 countermovement jumps were evaluated. The forces generated separately by arms and legs were assessed during 40-second tethered swimming. All indices of body composition were found strongly correlated with indices of average work and maximal power generated by arms and legs in dryland tests. RESULTS: Muscle mass of arms and trunk moderately and strongly (r = 0.44-0.64) influenced the force generated by arms in tethered swimming. There was no significance in the relationship of leg muscle mass and force generated by legs in tethered swimming. Significant relationships were observed between the results of the 100-m front crawl and the muscle mass of the arms, trunk, legs, as well as the average work and maximal power in the arm-cranking test (r: 0.39-0.54). The average impulse of arm force and maximal leg force in tethered swimming moderately and significantly correlated with 100-m swimming results. CONCLUSIONS: The study concludes the relevance of developing muscle mass balanced to the body size, which is involved in propulsion force production in sprint front crawl swimming.
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Ag-based plasmonic nanostructures were manufactured by thermal annealing of thin metallic films. Structure and morphology were studied using scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM) and X-ray photoelectron spectroscopy (XPS). SEM images show that the formation of nanostructures is influenced by the initial layer thickness as well as the temperature and the time of annealing. The Ag 3d and Ag 4d XPS spectra are characteristic of nanostructures. The quality of the nanostructures, in terms of their use as plasmonic platforms, is reflected in the UV-vis absorption spectra. The absorption spectrum is dominated by a maximum in the range of 450-500 nm associated with the plasmon resonance. As the initial layer thickness increases, an additional peak appears around 350 nm, which probably corresponds to the quadrupole resonance. For calculations leading to a better illustration of absorption, scattering and overall absorption of light in Ag nanoparticles, the Mie theory is employed. Absorbance and the distribution of the electromagnetic field around the nanostructures are calculated by finite-difference time-domain (FDTD) simulations. For calculations a novel approach based on modelling the whole sample with a realistic shape of the nanoparticles, instead of full spheres, was used. This led to a very good agreement with the experiment.
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Plasmonic platforms based on Au nanostructures have been successfully synthesized by directional solidification of a eutectic from Au and the substrate. In order to determine homogeneous shape and space distribution, the influence of annealing conditions and the initial thickness of the Au film on the nanostructures was analyzed. For the surface morphology studies, SEM and AFM measurements were performed. The structure of platforms was investigated using XRD and XPS methods. Structural investigations confirmed, that nanostructures consist of metallic Au, growing along the [111] direction. The most homogeneous seems to be the platform obtained by solidification of a 2.8 nm Au film, annealed at 550 °C for 15 min. This sample was subsequently chosen for theoretical calculations. Simulations of electromagnetic field propagation through the produced samples were performed using the finite-difference time domain (FDTD) method. The calculated absorbance, as a result of the FDTD simulation shows a quite good agreement with experimental data obtained in the UV-vis range.