RESUMO
Photosensitivity is a well-known complication of treatment with quinolone antibiotics. Several transient phototoxic drug reactions have been described. We report a case of a persistent phototoxic reaction to ciprofloxacin in a lung-transplant recipient on a long-term immunosuppressive drug regimen.
Assuntos
Anti-Infecciosos/efeitos adversos , Ciprofloxacina/efeitos adversos , Transplante de Pulmão , Transtornos de Fotossensibilidade/induzido quimicamente , Transtornos de Fotossensibilidade/patologia , Anti-Infecciosos/administração & dosagem , Ciprofloxacina/administração & dosagem , Feminino , Humanos , Terapia de Imunossupressão/efeitos adversos , Terapia de Imunossupressão/métodos , Pessoa de Meia-Idade , Transplante HomólogoRESUMO
Interferon alpha as adjuvant therapy in high risk melanoma delays relapses and distant metastasis as shown in large clinical trials and meta-analysis. There are clear signs that a long term low dose interferon therapy is especially effective in patients with micrometastasis (detected by sentinel node biopsy).Patient with stage IV melanoma (distant metastasis) need systemic therapy in most cases. Since until today there is no treatment that has been proven to prolong the overall survival for this patient population. We recommend according international guidelines that these patients are treated in the context of clinical trials in a melanoma reference center.