Detalhe da pesquisa
1.
In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A2A Receptor Antagonist/Inverse Agonist.
Mol Pharmacol
; 103(6): 311-324, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36894319
2.
Mechanistic analysis of the enhanced RNAi activity by 6-mCEPh-purine at the 5' end of the siRNA guide strand.
RNA
; 27(2): 151-162, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33177187
3.
siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.
RNA
; 27(2): 163-173, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33177188
4.
Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.
Bioorg Med Chem
; 27(22): 115122, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31623970
5.
Crystal structure of the GH-46 subclass III chitosanase from Bacillus circulans MH-K1 in complex with chitotetraose.
Biochim Biophys Acta Gen Subj
; 1868(3): 130549, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38158023
6.
Structural insight into an anti-BRIL Fab as a G-protein-coupled receptor crystallization chaperone.
Acta Crystallogr D Struct Biol
; 79(Pt 5): 435-441, 2023 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37098908
7.
The structure of L-amino-acid ligase from Bacillus licheniformis.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 11): 1535-40, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23090402
8.
Orientational correlations in two-dimensional liquid crystals studied by molecular dynamics simulation.
J Chem Phys
; 134(5): 054513, 2011 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21303144
9.
The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8+ T cells to tumors.
Am J Cancer Res
; 11(1): 264-276, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33520373
10.
Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resonance for identification of small-molecule Argonaute 2 inhibitors.
PLoS One
; 15(7): e0236710, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32735606
11.
The discovery of a new antibody for BRIL-fused GPCR structure determination.
Sci Rep
; 10(1): 11669, 2020 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32669569
12.
The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma.
Am J Cancer Res
; 10(12): 4399-4415, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33415007
13.
Structural comparison of fucosylated and nonfucosylated Fc fragments of human immunoglobulin G1.
J Mol Biol
; 368(3): 767-79, 2007 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-17368483
14.
Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.
Biochem J
; 405(3): 591-6, 2007 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17456047
15.
Development of Dihydrodibenzooxepine Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Ligands of a Novel Binding Mode as Anticancer Agents: Effective Mimicry of Chiral Structures by Olefinic E/ Z-Isomers.
J Med Chem
; 61(22): 10067-10083, 2018 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30351933
16.
The Discovery and Characterization of K-756, a Novel Wnt/ß-Catenin Pathway Inhibitor Targeting Tankyrase.
Mol Cancer Ther
; 15(7): 1525-34, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27196752
17.
Effect of the Titanium Nanoparticle on the Quantum Chemical Characterization of the Liquid Sodium Nanofluid.
J Phys Chem B
; 120(14): 3527-39, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27008416
18.
Bacillus circulans MH-K1 chitosanase: amino acid residues responsible for substrate binding.
J Biochem
; 138(5): 563-9, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16272568
19.
Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions.
J Radiat Res
; 56(4): 663-8, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25887043
20.
External beam radiotherapy for clinically node-negative, localized hormone-refractory prostate cancer: impact of pretreatment PSA value on radiotherapeutic outcomes.
Int J Radiat Oncol Biol Phys
; 59(2): 372-9, 2004 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15145150