RESUMO
BACKGROUND: Little is known whether sublingual immunotherapy using Japanese cedar pollen extract (cedar SLIT) is effective for not only Japanese cedar pollinosis but also Japanese cypress pollinosis. We investigated the prevalence rate of Japanese cypress pollinosis, efficacy of cedar SLIT on cypress pollinosis and patients' wish to receive cypress SLIT. METHODS: We investigated a multi-center (31 institutions), cross-sectional survey using a self-administrated questionnaire with four questions for patients received cedar SLIT aged from 5 to 69 years old. RESULTS: 2523 subjects were enrolled for analysis. 83.4% of them had pollinosis symptoms during cypress season before cedar SLIT. In such patients, 37.4% experienced lessened efficacy of cedar SLIT during cypress season. Both the prevalence of cypress pollinosis and the lessened efficacy of cedar SLIT on cypress pollinosis were significantly seen in western Japan as compared to eastern Japan. 76.1% of the subject having cypress pollinosis before SLIT wished to receive cypress SLIT if it is available. CONCLUSION: A lessened efficacy of cedar SLIT during cypress season was broadly seen in Japan, and further showed a regional difference. Together with the finding of high wish by patients, these results suggest a development of cypress SLIT is desirable.
Assuntos
Cryptomeria , Cupressus , Rinite Alérgica Sazonal , Imunoterapia Sublingual , Humanos , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Rinite Alérgica Sazonal/terapia , Rinite Alérgica Sazonal/tratamento farmacológico , Pólen , Estudos Transversais , Prevalência , Inquéritos e Questionários , AlérgenosRESUMO
Lipoblastoma is a rare benign tumor arising from embryonic white fat. We describe a case of huge lipoblastoma of the neck in a 1-year-old boy. Magnetic resonance imaging (MRI) revealed a 7 x 7 cm neck mass that extruded into the parapharyngeal and paratracheal spaces. At the operation, a well-circumscribed and extensively growing tumor was completely removed. Histopathologic examination showed that the tumor contained lobulated mature adipose tissue and myxoid tissue with lipoblasts and other immature fat cells. The postoperative course was uneventful, and no recurrence of tumor has been noted in more than 2 years follow-up.