RESUMO
OBJECTIVE: Descriptive and comparative study of patients with orbital IgG4-related disease. MATERIAL AND METHODS: A review and analysis of the cases diagnosed with inflammatory orbital lesion related to IgG4 by the Ophthalmic Pathology Service in the Dr. Luis Sánchez Bulnes Hospital. RESULTS: A total of 9 cases were found, in which 66% were women, and with a mean age of 48 years and time to diagnosis of 2 years. Unilateral involvement was observed in 56% of cases. All the females experienced pain, and there was an optimal response to corticosteroid treatment in 100% of patients who required medical treatment (one case showed spontaneous resolution). In bilateral cases (44%), only 25% were female, and none had pain as a presenting symptom. Furthermore, 25% of these patients required a combination with immunosuppressants to control inflammation. CONCLUSIONS: Clinical presentation of patients with unilateral orbital IgG4-related disease differs from those with bilateral involvement.
Assuntos
Dacriocistite/etiologia , Hipergamaglobulinemia/complicações , Imunoglobulina G , Doença de Mikulicz/etiologia , Doenças Orbitárias/etiologia , Corticosteroides/uso terapêutico , Adulto , Idoso , Doença Crônica , Estudos Transversais , Dacriocistite/diagnóstico , Dacriocistite/tratamento farmacológico , Dacriocistite/imunologia , Diagnóstico Tardio , Dor Ocular/etiologia , Feminino , Humanos , Imunoglobulina G/análise , Masculino , Pessoa de Meia-Idade , Doença de Mikulicz/diagnóstico , Doença de Mikulicz/tratamento farmacológico , Doença de Mikulicz/imunologia , Doenças Orbitárias/diagnóstico , Doenças Orbitárias/tratamento farmacológico , Doenças Orbitárias/imunologiaRESUMO
CASE REPORT: The case is presented of a 51 year-old woman with a firm mass at the medial canthus of the right eye of five years onset. A low-grade lymphoproliferative lesion (reactive lymphoid hyperplasia) was diagnosed from an excisional biopsy DISCUSSION: Lacrimal sac tumors are rare, with a peak incidence in the fifth decade of life. The initial clinical features are epiphora and medial canthus swelling. As it mimics nasolacrimal duct obstruction, up to 40% of these tumors are misdiagnosed until undergoing surgery.
Assuntos
Doenças do Aparelho Lacrimal/diagnóstico , Ducto Nasolacrimal/patologia , Pseudolinfoma/diagnóstico , Biópsia , Calcinose/diagnóstico por imagem , Feminino , Humanos , Doenças do Aparelho Lacrimal/diagnóstico por imagem , Doenças do Aparelho Lacrimal/cirurgia , Pessoa de Meia-Idade , Ducto Nasolacrimal/diagnóstico por imagem , Ducto Nasolacrimal/cirurgia , Órbita/diagnóstico por imagem , Pseudolinfoma/diagnóstico por imagem , Pseudolinfoma/cirurgia , Tomografia Computadorizada por Raios XRESUMO
PURPOSE: To analyze the clinicopathologic characteristics of uveal melanoma in Mexican patients under thirty years old. METHODS: We reviewed the cases from the Service of Ophthalmic Pathology with histopathologic diagnosis of uveal melanoma from 1957 to March 2002. The data analyzed were: age, gender, affected eye, clinical diagnosis, size, cellular type, mitotic index, lymphocytic infiltrate, vascular pattern, necrosis, vascular and/or intraocular invasion and orbital extension. RESULTS: We reviewed 122 cases diagnosed with uveal melanoma, and 14 patients were younger than 30 years old (11.4%). The mean age was 21.7 years, with female preponderance. Preoperative clinical diagnoses were uveal melanoma in 92.8%, most of the cases originated from choroid. The most frequent cellular type was spindle cells and 3 and 4 Folberg's vascular patterns. CONCLUSIONS: Our results suggest that the clinicians should consider uveal melanoma more frequently as another differential diagnosis in patients under thirty years with an intraocular tumor. The histological characteristics found have been correlated with a better prognosis.
Assuntos
Melanoma/patologia , Neoplasias Uveais/patologia , Adolescente , Adulto , Feminino , Humanos , Masculino , MéxicoRESUMO
OBJECTIVE: To determine the demographic and clinical data of primary tumors of the lacrimal sac presenting as lacrimal obstruction. METHODS: Retrospective and descriptive study was conducted between the years 2007 to 2012 on all patients undergoing surgery for low lacrimal obstruction at Dr. Luis Sanchez Bulnes Hospital, an Association for the prevention of blindness in Mexico IAP. RESULTS: Primary tumors of the lacrimal sac represented 2.5% of all lacrimal obstructions, being more common in women than in men (8:1). The large majority (89%) of the cases were non-epithelial, with lymphoid lesions being the most frequent. Benign tumors were presented at a younger age (50 years old) than malignant (70 years old). One-third (33%) of cases were unexpected findings during surgery (100% benign). Just over half (55%) were malignant tumors (1.4% of obstructions), all of them lymphoproliferative lesions. The most frequent clinical tumor was in the inner edge, either with or without epiphora. The progression time varied according to the degree of aggressiveness of the lymphoma (3 months-10 years). CONCLUSIONS: Lacrimal sac tumors are rare, but they must be taken into account in patients with an unusual clinical presentation of lacrimal obstruction.
Assuntos
Neoplasias Oculares/complicações , Doenças do Aparelho Lacrimal/complicações , Obstrução dos Ductos Lacrimais/etiologia , Linfoma não Hodgkin/complicações , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Oculares/epidemiologia , Feminino , Granuloma/complicações , Granuloma/epidemiologia , Humanos , Achados Incidentais , Doenças do Aparelho Lacrimal/epidemiologia , Obstrução dos Ductos Lacrimais/epidemiologia , Linfoma não Hodgkin/epidemiologia , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Nevo Azul/complicações , Nevo Azul/epidemiologia , Papiloma Invertido/complicações , Papiloma Invertido/epidemiologia , Prevalência , Estudos RetrospectivosRESUMO
CASE REPORT: We present the case of a 56 year-old male with a pulsating lesion in the temporal region of the left orbit as presenting sign of a renal cell carcinoma. A review is also presented of all cases of orbital metastases diagnosed in our hospital between 1957 and 2012. DISCUSSION: Carcinoma is the most common malignancy involving the kidney but, only rarely does it metastasize to the orbit. As these tumors can be confused with other amelanotic or vascular tumors, a high index of suspicion is required for early detection and management of the primary tumor.
Assuntos
Carcinoma de Células Renais/secundário , Neoplasias Renais/diagnóstico , Neoplasias Orbitárias/secundário , Carcinoma de Células Renais/irrigação sanguínea , Carcinoma de Células Renais/diagnóstico , Carcinoma de Células Renais/diagnóstico por imagem , Erros de Diagnóstico , Humanos , Neoplasias Renais/diagnóstico por imagem , Lipoma/diagnóstico , Masculino , Pessoa de Meia-Idade , Neoplasias Orbitárias/irrigação sanguínea , Neoplasias Orbitárias/diagnóstico , Neoplasias Orbitárias/diagnóstico por imagem , Fluxo Pulsátil , Tomografia Computadorizada por Raios XRESUMO
CASE REPORT: We report the case of a 48 year-old male with bilateral involvement of the salivary and lacrimal glands, which was diagnosed as Mikulicz's disease by incisional biopsy of the affected lacrimal glands, which was completely resolved after corticosteroid treatment. DISCUSSION: Sclerosing sialadenitis and/or dacryoadenitis are chronic inflammatory diseases that are currently classified into IgG4-related diseases. Specifically, Mikulicz's disease is defined by a persistent and symmetrical swelling of the lacrimal and salivary glands together with elevated serum concentration of IgG4 and tissue infiltration by IgG4 (+) plasma cells.
Assuntos
Doença de Mikulicz , Humanos , Masculino , Pessoa de Meia-Idade , Doença de Mikulicz/diagnóstico , Doença de Mikulicz/tratamento farmacológicoRESUMO
A 6-year-old girl presented with right divergent strabismus that had been noticed by her parents 3 weeks before. On examination, she had visual acuity of counting fingers at 3 meters on her right eye and retinal non-regmatogenous bullous detachment with subretinal tumor. Echographic examination disclosed retinal detachment in temporal side from optic disk to equator, a medium reflectivity rounded, homogeneous lesion with rapid growing and positive signs of vascularity. Enucleated eye revealed mixed cell uveal melanoma. This case is a rare presentation of uveal melanoma in which echographic appearance was decisive for diagnosis and treatment.