[Long-time observation of a case of retroperitoneal fibrosis with Klinefelter's syndrome (author's transl)]. / Langzeitverlauf bei einem Fall von retroperitonealer Fibrose (M. Ormond) mit Klinefelter-Syndrom.

The etiology of retroperitoneal fibrosis still is largely unknown. Autoimmunologic mechanisms, traumata, systemic diseases, and drugs have been discussed as possible etiologic factors. The presented case was found to have a Klinefelter's syndrome besides retroperitoneal fibrosis. We do not believe that there is a relation between the two diseases. The retroperitoneal fibrosis of this case responded well to glucocorticosteroid therapy and the severly reduced renal function became normal.

[Angiopathy in a case of primary oxalosis combined with familial spherocytosis (author's transl)]. / Angiopathie bei primärer Oxalose und gleichzeitiger hereditärer Sphärozytose.

An 18-year-old female with primary oxalosis, seen first when she was in advanced renal failure, developed a severe necrotizing angiopathy which began after a rapid decrease in renal function requiring chronic dialysis. Because of the severe angiopathy the preliminary diagnosis of an acute autoimmune vasculitis had been made. The correct diagnosis was revealed by renal biopsy and a renal transplantation performed. Soon after severe oxalosis led to failure of the renal transplant and death. The patient had also had familial spherocytosis, inherited from her father, while the oxalosis had been inherited from her mother. It is suggested that early transplantation at the onset of renal failure, as long as the blood oxalate level is still tolerably low, may give better results than have so far been reported.

[The use of photon absorptiometry in renal osteodystrophy (author's transl)]. / Bestimmung des Knochenmineralgehaltes mit Hilfe der Photonenabsorptionstechnik bei renaler Osteopathie.

In 58 patients with end-stage renal failure before commencement of regular hemodialyses treatment (RTD) and 58 patients under RTD bone mineral content (BMC) was determined by the use of the photon absorptiometry. Further the effect of a treatment with bitamin D3 and 5,6-trans-25-OH-vitamin D3 on BMC was studied. There existed a negative correlation between the duration of chronic renal failure or of RDT as well as of the serum parathyroid hormone level to BMC. No correlation was found between BMC and serum calcium level. During a 14 months-course treatment with vitamin D3 or 5,6-trans-25-OH-vitamin D3 BMC increased. The method of photon absorptiometry presented itself as an easy and well reproducible technique for routine examinations.

[Correlations between metabolisms of magnesium, calcium and parathormon (author's transl)]. / Beziehungen zwischen Magnesium-, Calcium- und Parathormonstoffwechsel.

Serum- or plasma levels of 102 healthy individuals as well as 78 patients with chronic renal insufficiency of various degrees were tested for parathormon (PTH), calcium, magnesium, anorganic phosphate, alkaline phosphatase, kreatinin, total protein as well as magnesium concentrations of the erythrocytes; attempts were made to correlate these parameters with each other. As most important finding in healthy individuals a significant negative correlation could be observed between serum PTH and magnesium of erythrocytes, whereas patients with renal insufficiency had a marked elevation and significant positive correlation between these two parameters. Since all other correlations were not as striking, if compared to these findings, we concluded that a feedback regulation system may exist in the intracellular magnesium concentration and PTH metabolism, so that an increase of the intracellular magnesium stimulates the PTH secretion, whereas elevated PTH activity causes a decrease of the intracellular magnesium together with a depression of the PTH release.