Detalhe da pesquisa
1.
Investigational New Drug Enabling Nonclinical Safety Pharmacology Assessment of the Iminosugar UV-4, a Broad-Spectrum Host-Targeted Antiviral Agent.
Int J Toxicol
; 41(3): 201-211, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35227115
2.
Investigational New Drug Enabling Nonclinical Safety Assessment of the Iminosugar UV-4, a Broad-Spectrum Host-Targeted Antiviral Agent.
Int J Toxicol
; 41(3): 182-200, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35426748
3.
Dengue Antiviral Development: A Continuing Journey.
Adv Exp Med Biol
; 1062: 319-332, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29845542
4.
Dengue Virus Evolution under a Host-Targeted Antiviral.
J Virol
; 89(10): 5592-601, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25762732
5.
Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.
Proc Natl Acad Sci U S A
; 110(43): 17486-91, 2013 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24101478
6.
Pharmacokinetics and pharmacodynamics of (+)-primaquine and (-)-primaquine enantiomers in rhesus macaques (Macaca mulatta).
Antimicrob Agents Chemother
; 58(12): 7283-91, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25267666
7.
A COVID-19 Infection Model Considering the Factors of Environmental Vectors and Re-Positives and Its Application to Data Fitting in Japan and Italy.
Viruses
; 15(5)2023 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37243286
8.
Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein.
EMBO J
; 27(23): 3209-19, 2008 Dec 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-19008861
9.
Reproductive and developmental toxicology studies of iminosugar UV-4.
Reprod Toxicol
; 114: 9-21, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36206921
10.
Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.
PLoS Negl Trop Dis
; 16(8): e0010636, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35939501
11.
Global Hopf bifurcation of a delayed phytoplankton-zooplankton system considering toxin producing effect and delay dependent coefficient.
Math Biosci Eng
; 16(5): 3807-3829, 2019 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31499637
12.
Threshold Dynamics of a Stochastic SIR Model with Vertical Transmission and Vaccination.
Comput Math Methods Med
; 2017: 4820183, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28761501
13.
Highlights of the 30th International Conference on Antiviral Research.
Antiviral Res
; 145: 184-196, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28774800
14.
Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain.
Novartis Found Symp
; 277: 87-97; discussion 97-101, 251-3, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17319156
15.
Finding new medicines for flaviviral targets.
Novartis Found Symp
; 277: 102-14; discussion 114-9, 251-3, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17319157
16.
The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice.
Viruses
; 8(3): 71, 2016 Mar 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27072420
17.
Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4.
Antiviral Res
; 129: 93-98, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26946111
18.
In vivo therapeutic protection against influenza A (H1N1) oseltamivir-sensitive and resistant viruses by the iminosugar UV-4.
PLoS One
; 10(3): e0121662, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25786028
19.
A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue).
Viruses
; 7(5): 2404-27, 2015 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25984714
20.
State-of-the-art therapeutic medical countermeasures for viral threat agents.
Biosecur Bioterror
; 9(4): 351-60, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22053938