1.
Chem Commun (Camb)
; 59(93): 13899-13902, 2023 Nov 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37934663
RESUMO
We describe a robust one-pot cascade method for the synthesis of indole-3-carboxylic acids using isatins and DMSO via a one-carbon translocation involving in situ generation of α,ß-unsaturated methylvinylsulfoxide followed by amide bond cleavage and ring closure. The methodology has been extended to afford anthranilic acid derivatives by tuning the reaction conditions in the presence of molecular oxygen. Importantly, easy access to commercially available drugs, including tropisetron, is demonstrated.