1.
Beilstein J Org Chem
; 20: 460-469, 2024.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38440170
RESUMO
Solutions of 1,3-diketones and 1,3-ketoester derivatives react with fluorine to give the corresponding 2,2-difluoro-1,3-dicarbonyl derivatives in the presence of quinuclidine. Quinuclidine reacts with fluorine in situ to generate a fluoride ion that facilitates limiting enolization processes, and an electrophilic N-F fluorinating agent that is reactive towards neutral enol species.