Detalhe da pesquisa
1.
Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitylase.
J Cell Sci
; 133(3)2020 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31964704
2.
CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage.
EMBO Rep
; 21(8): e48920, 2020 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32496651
3.
DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach.
Nucleic Acids Res
; 44(18): 8786-8798, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27407105
4.
Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.
Chemistry
; 21(50): 18109-21, 2015 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26531227
5.
Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring.
Chemistry
; 21(50): 17993, 2015 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26537992
6.
CDC7 inhibition drives an inflammatory response and a p53-dependent senescent-like state in breast epithelial cells.
FEBS J
; 2024 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38555567
7.
DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
J Cell Biol
; 223(8)2024 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38865090
8.
PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors.
iScience
; 26(6): 106951, 2023 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37378325
9.
Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation.
Bioorg Med Chem Lett
; 21(4): 1167-70, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21273066
10.
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.
Nat Chem Biol
; 4(6): 357-65, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18469809
11.
ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition.
Cell Rep
; 32(9): 108096, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32877678
12.
Cdc7 kinase inhibitors: pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships.
J Med Chem
; 51(3): 487-501, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18201066
13.
Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML.
Sci Rep
; 8(1): 15752, 2018 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30361682
14.
DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors.
ACS Chem Biol
; 12(7): 1893-1902, 2017 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28560864
15.
Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells.
Cancer Res
; 64(19): 7110-6, 2004 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15466207
16.
The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase.
Cancer Res
; 76(8): 2384-93, 2016 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26921344
17.
Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint.
Biol Open
; 5(1): 11-9, 2015 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26685311
18.
A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.
PLoS One
; 9(6): e98891, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24902048
19.
A cell culture system that mimics chronic lymphocytic leukemia cells microenvironment for drug screening and characterization.
Methods Mol Biol
; 986: 217-26, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23436415
20.
Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage.
FEBS J
; 280(19): 4888-902, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23910567