Detalhe da pesquisa
1.
Human PLD structures enable drug design and characterization of isoenzyme selectivity.
Nat Chem Biol
; 16(4): 391-399, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32042197
2.
Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors.
Bioorg Med Chem Lett
; 60: 128549, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041943
3.
Corrigendum to "Optimization of a novel piperazinone series as potent selective peripheral covalent BTK inhibitors" [Bioorg. Med. Chem. Lett. 60 (2022) 128549].
Bioorg Med Chem Lett
; 72: 128856, 2022 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35728998
4.
Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 67(10): 8122-8140, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38712838
5.
Discovery and Preclinical Characterization of BIIB091, a Reversible, Selective BTK Inhibitor for the Treatment of Multiple Sclerosis.
J Med Chem
; 65(2): 1206-1224, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34734694
6.
A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake.
J Biol Chem
; 285(17): 12882-91, 2010 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20172854
7.
Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo.
J Med Chem
; 64(20): 15402-15419, 2021 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34653340
8.
Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors.
ACS Med Chem Lett
; 11(4): 485-490, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292554
9.
Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.
J Med Chem
; 62(23): 10740-10756, 2019 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31710475
10.
Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation.
J Steroid Biochem Mol Biol
; 88(2): 191-201, 2004 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15084351
11.
Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants.
J Biol Chem
; 284(2): 1313-23, 2009 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-19001363
12.
Functional analysis of sites within PCSK9 responsible for hypercholesterolemia.
J Lipid Res
; 49(6): 1333-43, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18354137
13.
Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation.
J Biol Chem
; 282(28): 20502-12, 2007 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17493938
14.
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.
Bioorg Med Chem Lett
; 15(11): 2926-31, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15911283