Detalhe da pesquisa
1.
Complex Metabolism of the Novel Neurosteroid, Ganaxolone, in Humans: A Unique Challenge for Metabolites in Safety Testing Assessment.
Drug Metab Dispos
; 51(6): 753-763, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36863866
2.
Compound FC-10696 Inhibits Egress of Marburg Virus.
Antimicrob Agents Chemother
; 65(7): e0008621, 2021 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33846137
3.
Intravenously Administered Ganaxolone Blocks Diazepam-Resistant Lithium-Pilocarpine-Induced Status Epilepticus in Rats: Comparison with Allopregnanolone.
J Pharmacol Exp Ther
; 368(3): 326-337, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30552296
4.
The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes.
J Pharmacol Exp Ther
; 342(1): 23-32, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22431203
5.
MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo.
J Pharmacol Exp Ther
; 342(1): 15-22, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22473614
6.
Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians.
Eur J Hum Genet
; 30(10): 1159-1166, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35688891
7.
A Mouse Model of Furosemide-Induced Overactive Bladder.
Curr Protoc Pharmacol
; 74: 5.68.1-5.68.11, 2016 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27636110
8.
CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice.
Eur J Pharmacol
; 515(1-3): 179-87, 2005 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15904918
9.
Targeting the JNK pathway for therapeutic benefit in CNS disease.
Curr Drug Targets CNS Neurol Disord
; 1(1): 31-49, 2002 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12769633
10.
Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells.
Brain Res
; 1003(1-2): 86-97, 2004 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15019567
11.
Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases.
Prog Med Chem
; 40: 23-62, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12516522
12.
ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.
Neuron
; 83(2): 361-371, 2014 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25033180
13.
Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent.
J Med Chem
; 54(1): 179-200, 2011 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21126027
14.
Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-lineage kinase 1 crystallography, and oral in vivo activity in 1-methyl-4-phenyltetrahydropyridine models.
J Med Chem
; 51(18): 5680-9, 2008 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18714982
15.
Mixed lineage kinase activity of indolocarbazole analogues.
Bioorg Med Chem Lett
; 12(2): 147-50, 2002 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-11755341