[Changes in precorneal tear film and ocular surface in keratoconic patients after corneal collagen cross-linking]. / Izmenenie sostoyaniya prerogovichnoi sleznoi plenki i glaznoi poverkhnosti posle krosslinkinga rogovichnogo kollagena pri keratokonuse.

The article reviews the current available data on the signs and symptoms of dry eye syndrome (DES) in patients with keratoconus (KC), describes the clinical features of DES in KC patients and the morphological features of this type of keratectasia that lead to manifestations of the «dry eye¼, and highlights the risk factors, consequences of therapeutic measures, concomitant ophthalmological and general somatic diseases that contribute to the development of DES in KC.

[Precorneal tear film after corneal collagen cross-linking in keratoconus (preliminary report)]. / Sostoyanie prekorneal'noi sleznoi plenki posle krosslinkinga rogovichnogo kollagena pri keratokonuse (predvaritel'noe soobshchenie).

PURPOSE: To study the condition of precorneal tear film in keratoconus patients after corneal collagen cross-linking (CXL). MATERIAL AND METHODS: The study enrolled 24 patients (30 eyes) with stages I-III progressive keratoconus. All study patients underwent standard (Dresden) protocol CXL. Patients were examined before the surgery and 1 week, 1 month, and 3 months postoperatively. The condition of precorneal tear film was evaluated based on the results of Norn test (the tear film break-up time), Schirmer test, Jones test, optical coherence tomography based lacrimal meniscometry, and improved tearscopy. RESULTS: One month after CXL, patients with keratoconus experienced transient changes in the precorneal tear film condition - the tear film break-up time was reduced, the tear secretion was elevated, the lacrimal meniscus biometry parameters were increased, and the thickness of the tear film lipid layer was decreased. CONCLUSION: Corneal changes resulting from CXL lead to transient disorders of the mucin and lipid layers of the precorneal tear film, which requires adequate tear substitute therapy in the postoperative period.

[The effects of corneal collagen cross-linking on the corneal structure in keratoconus]. / Vliyanie krosslinkinga rogovichnogo kollagena na strukturu rogovitsy pri keratokonuse.

The article reviews the key information regarding morphological changes in keratoconic corneas and dramatic alterations of the corneal tissue induced by corneal cross-linking according to data obtained with in vivo corneal confocal microscopy, presents basic information on keratoconus visualization techniques widely used for diagnosis, monitoring of ectasia, as well as efficacy assessment of its treatment, and lists basic principles of corneal cross-linking procedure and confocal microscopy with consideration of morphology specifics of keratoconic corneas. The article also discusses prospective benefits of further research and longitudinal studies aimed to define the origin of keratoconus and to develop advanced corneal cross-linking protocols.