Detalhe da pesquisa
1.
Evaluation of Dynamic Contrast-Enhanced MRI Measures of Lung Congestion and Endothelial Permeability in Heart Failure: A Prospective Method Validation Study.
J Magn Reson Imaging
; 56(2): 450-461, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35343008
2.
Rationale and design of the Transformative Research in Diabetic Nephropathy (TRIDENT) Study.
Kidney Int
; 97(1): 10-13, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31901339
3.
Losmapimod, a novel p38 mitogen-activated protein kinase inhibitor, in non-ST-segment elevation myocardial infarction: a randomised phase 2 trial.
Lancet
; 384(9949): 1187-95, 2014 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24930728
4.
Safety, tolerability, pharmacokinetics and pharmacodynamics of losmapimod following a single intravenous or oral dose in healthy volunteers.
Br J Clin Pharmacol
; 76(1): 99-106, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23215699
5.
Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia.
Circulation
; 123(5): 515-23, 2011 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21262998
6.
The study of LoSmapimod treatment on inflammation and InfarCtSizE (SOLSTICE): design and rationale.
Am Heart J
; 164(5): 646-653.e3, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23137494
7.
Inhibition of p38 mitogen-activated protein kinase reduces inflammation after coronary vascular injury in humans.
Arterioscler Thromb Vasc Biol
; 30(11): 2256-63, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20689074
8.
Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature.
Arterioscler Thromb Vasc Biol
; 28(5): 850-5, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18276914
9.
In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats.
J Pharmacol Exp Ther
; 325(2): 466-74, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18287212
10.
Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol.
Arterioscler Thromb Vasc Biol
; 27(5): 1115-22, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17322100
11.
Human epicardial adipose tissue is a source of inflammatory mediators.
Circulation
; 108(20): 2460-6, 2003 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-14581396
12.
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
J Med Chem
; 48(17): 5419-22, 2005 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-16107141
13.
Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators.
Naunyn Schmiedebergs Arch Pharmacol
; 370(4): 238-50, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15549273
14.
A low-frequency variant in MAPK14 provides mechanistic evidence of a link with myeloperoxidase: a prognostic cardiovascular risk marker.
J Am Heart Assoc
; 3(4)2014 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25164947
15.
Effects of p38 mitogen-activated protein kinase inhibition on vascular and systemic inflammation in patients with atherosclerosis.
JACC Cardiovasc Imaging
; 5(9): 911-22, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22974804
16.
Quantitative analysis of orphan G protein-coupled receptor mRNAs by TaqMan Real-Time PCR: G2A and GPR4 lysophospholipid receptor expression in leukocytes and in a rat myocardial infarction-heart failure model.
Methods Mol Biol
; 306: 27-49, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-15867463
17.
Effect of treatment for 12 weeks with rilapladib, a lipoprotein-associated phospholipase A2 inhibitor, on arterial inflammation as assessed with 18F-fluorodeoxyglucose-positron emission tomography imaging.
J Am Coll Cardiol
; 63(1): 86-8, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-23973698
18.
PPARdelta activation normalizes cardiac substrate metabolism and reduces right ventricular hypertrophy in congestive heart failure.
J Cardiovasc Pharmacol
; 50(1): 25-34, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17666912
19.
Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux.
J Biol Chem
; 281(52): 39971-81, 2006 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17032648