Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros

Base de dados
Ano de publicação
Tipo de documento
Intervalo de ano de publicação
1.
PLoS One ; 19(1): e0296950, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38285666

RESUMO

Nonalcoholic steatohepatitis (NASH) occurs worldwide and is characterized by lipid accumulation in hepatocytes, hepatic inflammation, fibrosis, and an increased risk of cirrhosis. Although a major proportion of NASH patients exhibit obesity and insulin resistance, 20% lack a high body mass and are categorized as "non-obese NASH". Time-restricted feeding (TRF), limiting daily food intake within certain hours, improves obesity, lipid metabolism, and liver inflammation. Here, we determined whether TRF affects NASH pathology induced by a choline-deficient high-fat diet (CDAHFD), which does not involve obesity. TRF ameliorated the increase in epididymal white adipose tissue and plasma alanine transaminase and aspartate transaminase levels after 8 weeks of a CDAHFD. Although gene expression of TNF alpha in the liver was suppressed by TRF, it did not exhibit a suppressive effect on hepatic lipid accumulation, gene expression of cytokines and macrophage markers (Mcp1, IL1b, F4/80), or fibrosis, as evaluated by Sirius red staining and western blot analysis of alpha-smooth muscle actin. A CDAHFD-induced increase in gene expression related to fibrogenesis (Collagen 1a1 and TGFß) was neither suppressed by TRF nor that of alpha-smooth muscle actin but was increased by TRF. Our results indicated that TRF has a limited suppressive effect on CDAHFD-induced NASH pathology.


Assuntos
Deficiência de Colina , Hepatopatia Gordurosa não Alcoólica , Humanos , Animais , Camundongos , Hepatopatia Gordurosa não Alcoólica/patologia , Colina/metabolismo , Dieta Hiperlipídica/efeitos adversos , Actinas/metabolismo , Deficiência de Colina/metabolismo , Fígado/metabolismo , Cirrose Hepática/patologia , Inflamação/patologia , Fibrose , Obesidade/complicações , Lipídeos/efeitos adversos , Camundongos Endogâmicos C57BL , Modelos Animais de Doenças
2.
J Cardiol Cases ; 29(3): 108-111, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38481640

RESUMO

Dystrophic calcification is a rare but fatal complication associated with severe myocarditis. Detecting calcified lesions and evaluating ventricular function are essential for the management of myocarditis. We report a case of neonatal acute myocarditis with dystrophic calcification successfully assessed by two-dimensional speckle-tracking echocardiography. The calcification spontaneously resolved, and the recovery of myocardial function was evaluated by speckle-tracking echocardiography. Speckle-tracking echocardiography could be a useful method to evaluate regional ventricular dysfunction corresponding to dystrophic calcification as well as that caused by myocarditis and the follow-up because of its repeatability. Learning objective: 1) Dystrophic calcification can occur as a rare complication associated with severe myocarditis. 2) Dystrophic calcification can spontaneously resolve with the recovery of myocardial function. 3) Speckle-tracking echocardiography is a useful tool for the evaluation of the extent of and myocardial function in dystrophic calcification and the follow-up.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA