Evidence for DNA resonance signaling via longitudinal hydrogen bonds.

The theory of the morphogenic field suggests that chemical signaling is supplemented by electromagnetic signaling governing the structure and shape of tissues, organs and the body. The theory of DNA resonance suggests that the morphogenic field is created by the genomic DNA which sends and receives electromagnetic signals in a sequence-specific manner. Previously, the authors have proposed the existence of HIDERs, genomic elements that serve as antennas in resonance signaling and demonstrated that they occur nonrandomly and are conserved in evolution. Here, it is proposed that longitudinal hydrogen bonds exist in the double helix, that chains of these bonds form delocalized proton clouds, that the shapes of these clouds are sequence-specific and form the basis of sequence-specificity of resonance between HIDERs. Based on longitudinal hydrogen bonds, a proton DNA resonance code was devised and used to identify HIDERs which are enriched 20 fold in the genome and conserved in evolution. It was suggested that these HIDERs are the key elements responsible for DNA resonance signaling and the formation of the morphogenic field.

Possible traces of resonance signaling in the genome.

Although theories regarding the role of sequence-specific DNA resonance in biology have abounded for over 40 years, the published evidence for it is lacking. Here, the authors reasoned that for sustained resonance signaling, the number of oscillating DNA sequences per genome should be exceptionally high and that, therefore, genomic repeats of various sizes are good candidates for serving as resonators. Moreover, it was suggested that for the two DNA sequences to resonate, they do not necessarily have to be identical. Therefore, the existence of sequences differing in the primary sequence but having similar resonating sub-structures was proposed. It was hypothesized that such sequences, named HIDERs, would be enriched in the genomes of multicellular species. Specifically, it was hypothesized that delocalized electron clouds of purine-pyrimidine sequences could serve as the basis of HIDERs. The consequent computational genomic analysis confirmed the enrichment of purine-pyrimidine HIDERs in a few selected genomes of mammals, an insect, and a plant, compared to randomized sequence controls. Similarly, it was suggested that hypothetical delocalized proton clouds of the hydrogen bonds of multiple stacked bases could serve as sequence-dependent hydrogen-bond-based HIDERs. Similarly, the enrichment of such HIDERs was observed. It is suggested that these enrichments are the first evidence in support of sequence-specific resonance signaling in the genome.