Detalhe da pesquisa
1.
Allosteric activation of MALT1 by its ubiquitin-binding Ig3 domain.
Proc Natl Acad Sci U S A
; 117(6): 3093-3102, 2020 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980531
2.
Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.
J Biol Chem
; 290(18): 11376-83, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25833948
3.
Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.
Bioorg Med Chem Lett
; 25(19): 4097-103, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26318993
4.
N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.
Bioorg Med Chem Lett
; 25(19): 4104-8, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26321360
5.
A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway.
Bioorg Med Chem Lett
; 23(20): 5578-85, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24007918
6.
Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis.
Bioorg Med Chem Lett
; 22(9): 3349-53, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22469702
7.
A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia.
J Med Chem
; 65(18): 12014-12030, 2022 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36094045
8.
Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.
J Biol Chem
; 290(48): 28726, 2015 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26614783
9.
ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy.
Sci Transl Med
; 13(613): eabd5016, 2021 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34586834
10.
Design of the LifeArc Index Set and Retrospective Review of Its Performance: A Collection for Sharing.
SLAS Discov
; 24(3): 332-345, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30290126
11.
Inhibition of the ERCC1-XPF structure-specific endonuclease to overcome cancer chemoresistance.
DNA Repair (Amst)
; 31: 19-28, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25956741
12.
Identification of small-molecule inhibitors of the ribonuclease H2 enzyme.
J Biomol Screen
; 18(5): 610-20, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23427046
13.
Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay.
BMJ Open
; 3(6)2013 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23794563
14.
An intrinsically labile α-helix abutting the BCL9-binding site of ß-catenin is required for its inhibition by carnosic acid.
Nat Commun
; 3: 680, 2012 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22353711
15.
Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.
J Med Chem
; 55(7): 3578-82, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22439843
16.
A high-throughput assay for modulators of NNT activity in permeabilized yeast cells.
J Biomol Screen
; 16(7): 734-43, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21602486
17.
Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.
Tuberculosis (Edinb)
; 91(4): 277-86, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21482481