Detalhe da pesquisa
1.
Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus.
N Engl J Med
; 386(11): 1034-1045, 2022 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35294813
2.
Circulating biomarker analyses in a longitudinal cohort of patients with IPF.
Am J Physiol Lung Cell Mol Physiol
; 326(3): L303-L312, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38226605
3.
Biological impact of iberdomide in patients with active systemic lupus erythematosus.
Ann Rheum Dis
; 2022 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35477518
4.
Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity.
J Immunol
; 199(7): 2388-2407, 2017 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28848067
5.
Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus.
Ann Rheum Dis
; 77(10): 1516-1523, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945920
6.
Mechanisms Underlying the Clinical Effects of Apremilast for Psoriasis.
J Drugs Dermatol
; 17(8): 835-840, 2018 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30124722
7.
CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL.
Blood
; 126(6): 779-89, 2015 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26002965
8.
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).
Br J Haematol
; 164(6): 811-21, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24328678
9.
Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity.
Br J Haematol
; 164(2): 233-44, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24206017
10.
Synergistic cytokine effects as apremilast response predictors in patients with psoriasis.
J Allergy Clin Immunol
; 142(3): 1010-1013.e6, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29936103
11.
Urinary Proteomics and Outcomes in Heart Failure With Preserved Ejection Fraction.
J Am Heart Assoc
; 13(9): e033410, 2024 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-38639358
12.
Proteomic Associations of NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) in Heart Failure With Preserved Ejection Fraction.
Circ Heart Fail
; 17(2): e011146, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38299345
13.
Lenalidomide efficacy in activated B-cell-like subtype diffuse large B-cell lymphoma is dependent upon IRF4 and cereblon expression.
Br J Haematol
; 160(4): 487-502, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23252516
14.
Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.
Bioorg Med Chem Lett
; 23(1): 360-5, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23168019
15.
Efficacy, tolerability, and pharmacodynamics of apremilast in recalcitrant plaque psoriasis: a phase II open-label study.
J Drugs Dermatol
; 12(8): 888-97, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23986162
16.
Effect of an angiogenesis inhibitor on hepatic tumor perfusion and the implications for adjuvant cytotoxic therapy.
Radiology
; 264(1): 68-77, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22627603
17.
Pomalidomide is effective for prevention and treatment of experimental skin fibrosis.
Ann Rheum Dis
; 71(11): 1895-9, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22904257
18.
Iberdomide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled, ascending-dose, phase 2a study.
Lupus Sci Med
; 9(1)2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35169036
19.
Endotrophin, a Collagen VI Formation-Derived Peptide, in Heart Failure.
NEJM Evid
; 1(10)2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37645406
20.
Lenalidomide downregulates the cell survival factor, interferon regulatory factor-4, providing a potential mechanistic link for predicting response.
Br J Haematol
; 154(3): 325-36, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21707574