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1.
J Am Pharm Assoc (2003) ; 63(4S): S8-S13, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36549929

RESUMO

BACKGROUND: The American College of Rheumatology strongly recommends a treat-to-target management strategy to achieve and maintain serum uric acid (sUA) less than 6 mg/dL to decrease risk of gouty flare recurrence and permanent joint damage. OBJECTIVE: To compare the effectiveness of rheumatology clinic pharmacists and primary care providers (PCPs) in achieving a target sUA goal in patients with gout. METHODS: This retrospective chart review included patients aged 18 years and older starting urate-lowering therapy (ULT) (allopurinol, febuxostat, or probenecid) for gout between January 1, 2015, and December 31, 2019. Exclusion criteria were ULT use within the previous 6 months, baseline sUA less than 6 mg/dL, and death within 12 months of starting ULT. From ULT initiation, data were collected until sUA less than 6 mg/dL was achieved or a maximum of 12 months. The primary outcome was the percentage of patients who achieved sUA less than 6 mg/dL. Key secondary outcomes were percent reduction in sUA and time to sUA target achievement. RESULTS: Of 62 patients included in each group, 75.8% of patients in the pharmacist cohort versus 30.6% of patients in the PCP cohort achieved target sUA less than 6 mg/dL (odds ratio 7.09, 95% confidence interval 3.28-16.11, P < 0.001). Patients in the pharmacist-managed group also achieved a greater reduction in mean sUA (-36.7% vs. -26.9% respectively, P = 0.001). Among patients achieving target sUA, median time to target was similar at 92 and 86 days, respectively, despite significantly lower initial mean allopurinol doses in the pharmacist-managed group (102 mg/d vs. 145 mg/d, P < 0.001). CONCLUSION: The odds of achieving target sUA within 12 months were 7 times higher if gout was managed by a rheumatology clinic pharmacist as compared with a PCP. This study suggests the need for prescriber education and supports expansion of pharmacist-led gout management to primary care settings.

2.
J Am Pharm Assoc (2003) ; 61(1): 20-26, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33012670

RESUMO

OBJECTIVES: The use of e-cigarettes is becoming more common in the United States. E-cigarettes are often refilled with nicotine-containing solutions of various concentrations purchased in local shops or on the Internet. There is evidence that the nicotine content in these solutions is often mislabeled; thus, we reviewed the available literature on this topic. DATA SOURCES: We conducted a systematic review of peer-reviewed articles published worldwide on e-liquid nicotine content accuracy using the databases CAB Direct, Cochrane Central Register of Controlled Trials, PubMed, and SPORTDiscus (EBSCO). STUDY SELECTION: Initial screening of titles and abstracts was conducted to determine relevancy for inclusion. Full-article reviews of studies involving the purchase and chemical analysis of nicotine content in refillable e-liquids were conducted for final inclusion. DATA EXTRACTION: Data extraction included e-liquid sample size, whether the samples were labeled to contain nicotine, whether the samples were purchased in retail shops or online, and the number and percentage of samples where the analyzed nicotine content fell outside 10% of the labeled nicotine content. RESULTS: Twenty articles described cross-sectional studies of purchased samples containing nicotine. The number of nicotine-containing e-liquid samples obtained in each study varied from 2 to 71. The percentage of samples with an analyzed nicotine concentration of more than 10% above or below the labeled nicotine concentration ranged from 0% to 100% (277/574 or 48.3%; median 46.85%). A large percentage of the samples deviated by 10% from the labeled nicotine concentrations in both U.S. and non-U.S. samples, with U.S. samples having a higher percentage. CONCLUSION: Our review shows that actual nicotine concentrations in e-liquids may vary considerably from labeled concentrations. Pharmacists should warn patients to be wary of the contents of e-cigarettes, and explain the dangers of using these products.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Nicotina , Estudos Transversais , Humanos , Marketing , Estados Unidos
3.
J Pediatr Nurs ; 59: 45-54, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33460879

RESUMO

PURPOSE: To expand on our 2015 study of the nicotine content accuracy of e-liquids, including salts, and the presence of child-resistant packaging. We also describe compounding in shop (CIS). DESIGN AND METHODS: We analyzed samples from 35 shops. CIS processing was observed. Descriptive statistics summarized the data, and inference was performed. RESULTS: Actual nicotine content was significantly less than the identified content, on average, with a mean percent deviation 34.0% below the identified content. Only 3.8% of the samples' actual nicotine content was within 10% of the identified content; the maximum deviation was 213.2%. Of eight uniquely packaged samples, including designs resembling pop cans, ice cream cones, etc., the mean percent deviation was -39.6%; none were within 10% of the identified content. Eight shops compounded samples. After removing outlier values, significant differences were found in the percent deviations between the CIS and non-CIS free-base samples. A significantly higher percentage of CIS samples had nicotine content > 10% above the identified content, and none were within 10%. One shop visually estimated the nicotine quantities to add, e-liquids were not always relabeled to reflect new nicotine levels, and protective materials were not always worn during compounding. Child-resistant packaging was not present for one third of the samples. CONCLUSIONS: Labeling of nicotine content in e-liquids remains inaccurate, child-resistant packaging is inconsistent, and CIS is problematic. Effective e-liquid regulation is needed to protect public health. PRACTICE IMPLICATIONS: Nurses should educate families about the serious health risks of e-liquids and advocate for increased e-liquid regulations.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Nicotina , Humanos , Rotulagem de Produtos , Embalagem de Produtos
4.
Public Health Nurs ; 38(5): 879-884, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33938043

RESUMO

OBJECTIVE: To determine compliance with North Dakota's smoke-free law in vape shops and other tobacco specialty shops selling electronic nicotine delivery systems (ENDS) or e-liquids. DESIGN: In this 2019 descriptive study, shops (n = 35) were assessed for compliance with the smoke-free law by observation of indoor and outdoor areas for smoking or vaping, or evidence of such activity in prohibited areas, and the presence of required no-smoking signs. RESULTS: Only two shops (5.7%) were fully compliant with the smoke-free law. Full compliance for indoor and outdoor environments was 8.5% and 42.8%, respectively. Vaping occurred inside five shops (14.3%), and smoking occurred outdoors within required smoke-free areas in two (5.7%) shops. Four (11.4%) and 17 (48.6%) shops complied with indoor and outdoor signage requirements, respectively. CONCLUSIONS: Overall compliance remained low, although much of the noncompliance was related to signage. Use or evidence of ENDS use occurred both indoors and outdoors where prohibited by law. Classifying ENDS as tobacco products would require tobacco licensure of shops selling ENDS and e-liquids, aiding in identification of the shops for education and enforcement efforts to ensure compliance with the law and to improve public health protection.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Política Antifumo , Produtos do Tabaco , Poluição por Fumaça de Tabaco , Vaping , Humanos , North Dakota , Nicotiana , Poluição por Fumaça de Tabaco/prevenção & controle
5.
Nurs Res ; 67(4): 324-330, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29870518

RESUMO

BACKGROUND: Rural populations have been identified as having tobacco use disparities, with contributing factors including less demand for policy change than in urban areas, resulting in higher age-adjusted death rates related to tobacco use. In 2012, the rural state of North Dakota enacted a statewide comprehensive law requiring all bars and restaurants to be smoke-free. OBJECTIVES: The purpose of this longitudinal study, performed in three phases, was to assess the continued effects of a statewide comprehensive smoke-free law in a primarily rural state, using a stratified random sample. METHODS: Particulate matter and compliance indicators were assessed in restaurants and bars 21 months after enactment of the comprehensive law. Results were compared with the findings from the Phase 1 and Phase 2 samples, in which venues were assessed before passage of the law and approximately 3 months after enactment, respectively. RESULTS: The comprehensive, statewide, smoke-free law led to immediate, sustained, and substantial reductions in secondhand smoke and eliminated previous significant disparities in secondhand smoke exposure in rural communities. Although indoor smoke-free compliance with the law was generally high, compliance in required outdoor smoke-free areas was low. Compliance with signage requirements, both indoors and outdoors, was low. DISCUSSION: The comprehensive statewide smoke-free law created a just distribution of smoke-free laws statewide, resulting in increased protection of rural populations from secondhand smoke. Targeted public health interventions to address compliance may reduce secondhand smoke levels in outlier venues that continue to have high levels of secondhand smoke.


Assuntos
Política de Saúde/legislação & jurisprudência , Restaurantes/tendências , Poluição por Fumaça de Tabaco/efeitos adversos , Poluentes Atmosféricos/análise , Exposição Ambiental/efeitos adversos , Humanos , Estudos Longitudinais , North Dakota , População Rural
6.
Tob Control ; 26(4): 452-454, 2017 07.
Artigo em Inglês | MEDLINE | ID: mdl-27343228

RESUMO

OBJECTIVE: To determine whether retail stores selling electronic smoking devices or liquid nicotine were compliant with North Dakota's smoke-free law. METHODS: During June 2015, retail stores selling electronic smoking devices or liquid nicotine (n=16), but not legally required to be licensed to sell tobacco products, were assessed for compliance with North Dakota's smoke-free law by observing for smoking or e-smoking, or evidence of such, in prohibited areas and for the presence of required no-smoking signs. RESULTS: Use of e-cigarettes, or evidence of use, was observed inside 8 (50%) stores required to be smoke-free. On the basis of all indicators of compliance assessed, compliance with the state's smoke-free law was low, with only 6% and 44% of stores compliant with all indoor and outdoor requirements, respectively. CONCLUSIONS: To the best of our knowledge, this is the first U.S. study assessing retail stores selling electronic smoking devices or liquid nicotine for compliance with the smoke-free law. The use of e-cigarettes, or evidence of use, occurred in the stores where it is prohibited by law. Overall compliance with the smoke-free law was low. These stores should be licensed by the state, as are other tobacco retailers, because this may assist in education, enforcement and compliance with the law and increase public health protection.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Aplicação da Lei , Política Antifumo/legislação & jurisprudência , Poluição por Fumaça de Tabaco/legislação & jurisprudência , Comércio , Sistemas Eletrônicos de Liberação de Nicotina/economia , Humanos , North Dakota
7.
Public Health Nurs ; 34(2): 166-175, 2017 03.
Artigo em Inglês | MEDLINE | ID: mdl-27723116

RESUMO

OBJECTIVE: In 2012, North Dakota enacted a comprehensive statewide law prohibiting smoking in enclosed public places. Disparities in tobacco control exist in rural areas. This study's objective was to determine the extent to which the passage of a comprehensive, statewide, smoke-free law in a predominantly rural state influenced tobacco smoke pollution in rural and nonrural venues. DESIGN AND SAMPLE: A longitudinal cohort design study comparing the levels of tobacco smoke pollution before and after passage of the statewide smoke-free law was conducted in 64 restaurants and bars statewide in North Dakota. MEASURES: Particulate matter with a median aerodynamic diameter of <2.5 µm (a valid atmospheric marker of tobacco smoke pollution) was assessed. RESULTS: A significant 83% reduction in tobacco smoke pollution levels occurred after passage of the law. Significant reductions in tobacco smoke pollution levels occurred in each of the rural categories; however, no difference by rurality was noted in the analysis after passage of the law, in contrast to the study before passage. CONCLUSIONS: To our knowledge, this was the largest, single, rural postlaw study globally. A comprehensive statewide smoke-free law implemented in North Dakota dramatically decreased the level of tobacco smoke pollution in bars and restaurants.


Assuntos
Restaurantes/legislação & jurisprudência , Política Antifumo/legislação & jurisprudência , Poluição por Fumaça de Tabaco/prevenção & controle , Humanos , Estudos Longitudinais , North Dakota , População Rural
8.
J Pediatr Nurs ; 31(4): 373-9, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27079973

RESUMO

UNLABELLED: To determine the accuracy of the labeled quantity of the nicotine content of the e-liquids sold in unlicensed vape stores, whether the packaging of e-liquids sold within the vape stores was child-resistant, whether minors were present within vape stores, and whether sales to minors occurred. This study was conducted across North Dakota prior to implementation of a new e-cigarette state law and provided a baseline assessment before enactment of the new legal requirements. DESIGN AND METHODS: We tested samples of e-liquids and performed observations in 16 stores that were selling e-cigarettes but were not legally required to be licensed for tobacco retail. The e-liquids were analyzed for nicotine content using a validated high-performance liquid chromatography method for nicotine analysis. RESULTS: Of the 70 collected e-liquid samples that claimed to contain nicotine, 17% contained more than the labeled quantity and 34% contained less than the labeled quantity by 10% or more, with one sample containing 172% more than the labeled quantity. Of the 94 e-liquid containers sampled, only 35% were determined to be child-resistant. Minors were present in stores, although no sales to minors occurred. CONCLUSIONS: Mislabeling of nicotine in e-liquids is common and exposes the user to the harmful effects of nicotine. The lack of child-resistant packaging for this potentially toxic substance is a serious public health problem. E-cigarettes should be included in the legal definition of tobacco products, child-resistant packaging and nicotine labeling laws should be enacted and strictly enforced, and vape stores should be licensed by states.


Assuntos
Comércio/legislação & jurisprudência , Sistemas Eletrônicos de Liberação de Nicotina/legislação & jurisprudência , Sistemas Eletrônicos de Liberação de Nicotina/estatística & dados numéricos , Nicotina/efeitos adversos , Rotulagem de Produtos/normas , Adolescente , Criança , Estudos Transversais , Sistemas Eletrônicos de Liberação de Nicotina/efeitos adversos , Feminino , Aromatizantes , Regulamentação Governamental , Humanos , Masculino , Menores de Idade , Nicotina/administração & dosagem , Formulação de Políticas , Embalagem de Produtos , Gestão da Segurança , Estados Unidos
9.
Res Nurs Health ; 38(4): 268-77, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25962373

RESUMO

The purpose of this cross-sectional study in a stratified random sample of 135 bars and restaurants in North Dakota was to describe factors that influenced tobacco smoke pollution levels in the venues; to compare the quantity of tobacco smoke pollution by rurality and by presence of local ordinances; and to assess compliance with state and local laws. In data collection in 2012, we measured the indoor air quality indicator of particulate matter (2.5 microns aerodynamic diameter or smaller), calculated average smoking density and occupant density, and determined compliance with state and local smoking ordinances using observational methods. As rurality increased, tobacco smoke pollution in bars increased. A significant association was found between stringency of local laws and level of tobacco smoke pollution, but the strength of the association varied by venue type. Compliance was significantly lower in venues in communities without local ordinances. Controlling for venue type, 69.2% of smoke-free policy's impact on tobacco smoke pollution levels was mediated by observed smoking. This study advances scientific knowledge on the factors influencing tobacco smoke pollution and informs public health advocates and decision makers on policy needs, especially in rural areas.


Assuntos
Poluição do Ar em Ambientes Fechados/análise , Poluição do Ar em Ambientes Fechados/legislação & jurisprudência , Restaurantes/legislação & jurisprudência , Política Antifumo/legislação & jurisprudência , Fumar/legislação & jurisprudência , Poluição por Fumaça de Tabaco/análise , Poluição por Fumaça de Tabaco/legislação & jurisprudência , Estudos Transversais , Exposição Ambiental/análise , Exposição Ambiental/legislação & jurisprudência , Monitoramento Ambiental , Governo Federal , Humanos , Governo Local , North Dakota , População Rural , Governo Estadual , População Urbana
10.
Laryngoscope ; 134(2): 795-802, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37602761

RESUMO

OBJECTIVES: Vocal process granulomas (VPGs) are benign laryngeal lesions that may manifest as ulcerated regions of the vocal fold or nodular polypoid lesions. Gold standard treatments for idiopathic VPG are yet to be established at this time. This study evaluated clinical decision-making and outcomes in the treatment of VPG patients based on experiences of academic laryngologists across the United States. METHODS: A 21-question survey was developed to evaluate each respondent's specific VPG patient population, clinical decision-making in treating VPG, and corresponding treatment outcomes. The survey was distributed to 168 laryngologists at academic institutions across the United States. Data were analyzed through the Qualtrics platform. RESULTS: A total of 106 responses were analyzed, with a completion rate of 63.1%. Etiology of VPG was most commonly attributed to phonotrauma (96.2%) and reflux (71.8%). Primary first-line treatment was most commonly antireflux medications (92%). Other common first line treatments included voice therapy (58.8%) and inhaled steroids (42.5%). With these treatments, the majority of laryngologists report that recurrence is uncommon (68.4%). Dysphonia was cited as the most frequent long-term sequelae at 27.8%. CONCLUSIONS: VPG treatment strategies continue to be controversial across the United States with many treatments described in the literature with variable application in the practice of academic laryngologists today. Based on survey results, antireflux medications and voice therapy may be the most widely used and most effective treatment options. Establishment of gold standard therapy for VPG as well as further research into recurrent or persistent VPG despite antireflux and voice therapy should be explored. LEVEL OF EVIDENCE: 5 Laryngoscope, 134:795-802, 2024.


Assuntos
Disfonia , Laringe , Voz , Humanos , Granuloma , Prega Vocal , Disfonia/complicações
11.
Toxics ; 12(5)2024 May 18.
Artigo em Inglês | MEDLINE | ID: mdl-38787151

RESUMO

E-liquids contain combinations of chemicals, with many enhancing the sensory attractiveness of the product. Studies are needed to understand and characterize e-liquid ingredients, particularly flavorings, to inform future research and regulations of these products. We identified common flavor ingredients in a convenience sample of commercial e-liquids using gas chromatography-mass spectrometry. E-liquid flavors were categorized by flavor descriptors provided on the product packaging. A Flavor Ingredient Wheel was developed to link e-liquid flavor ingredients with flavor categories. An analysis of 109 samples identified 48 flavor ingredients. Consistency between the labeled flavor and ingredients used to produce such flavor was found. Our novel Flavor Ingredient Wheel organizes e-liquids by flavor and ingredients, enabling efficient analysis of the link between ingredients and their flavor profiles and allowing for quick assessment of an e-liquid ingredient's flavor profile. Investigating ingredient profiles and identifying and classifying commonly used chemicals in e-liquids may assist with future studies and improve the ability to regulate these products.

12.
J Adv Nurs ; 68(4): 948-58, 2012 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-22032609

RESUMO

AIM: This article is a report of an analysis of the concept of social justice. BACKGROUND: Nursing's involvement in social justice has waned in the recent past. A resurgence of interest in nurses' roles about social justice requires a clear understanding of the concept. DATA SOURCES: Literature for this concept analysis included English language articles from CINAHL, PubMed, and broad multidisciplinary literature databases, within and outside of health-related literature, for the years 1968-2010. Two books and appropriate websites were also reviewed. The reference lists of the identified sources were reviewed for additional sources. REVIEW METHODS: The authors used Wilsonian methods of concept analysis as a guide. RESULTS: An efficient, synthesized definition of social justice was developed, based on the identification of its attributes, antecedents and consequences that provides clarification of the concept. Social justice was defined as full participation in society and the balancing of benefits and burdens by all citizens, resulting in equitable living and a just ordering of society. Its attributes included: (1) fairness; (2) equity in the distribution of power, resources, and processes that affect the sufficiency of the social determinants of health; (3) just institutions, systems, structures, policies, and processes; (4) equity in human development, rights, and sustainability; and (5) sufficiency of well-being. CONCLUSION: Nurses can have an important influence on the health of people globally by reinvesting in social justice. Implications for research, education, practice and policy, such as development of a social justice framework and educational competencies are presented.


Assuntos
Ética em Enfermagem , Papel do Profissional de Enfermagem , Enfermagem em Saúde Pública/ética , Justiça Social/ética , Formação de Conceito , Bases de Dados Bibliográficas , Humanos
13.
J Athl Train ; 57(2): 177-183, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34185839

RESUMO

This case report discusses a 16-year-old female volleyball, basketball, and track and field athlete who was diagnosed with a Chiari I malformation after a concussion. Surgical decompression was recommended and performed 3 months after her initial diagnosis. This patient presented unique challenges due to her age, desire to return to sport, and lack of access to medical care due to living in a rural area. Few evidence-based best-practice recommendations are available for the management and return to sport of patients with Chiari I malformation, particularly for those who have undergone surgical decompression. In this case study, we address the treatment and return-to-sport process for the patient and provide a comprehensive review of the published literature on patients attempting to return to sport after a diagnosis of Chiari I malformation. In addition, we explore the value of an athletic trainer in reconciling various barriers in management and return to sport evident in this case and the reviewed literature.


Assuntos
Malformação de Arnold-Chiari , Concussão Encefálica , Esportes , Adolescente , Malformação de Arnold-Chiari/cirurgia , Malformação de Arnold-Chiari/terapia , Concussão Encefálica/diagnóstico , Descompressão Cirúrgica , Feminino , Humanos , Imageamento por Ressonância Magnética , Volta ao Esporte
14.
J Biomech Eng ; 132(9): 091012, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20815646

RESUMO

Ligament cross-sectional areas are difficult to determine because ligaments are soft tissues, can be very short, and may be deep between bones. However, accurate measurements are required for determining the material properties from mechanical testing. Many techniques have been tried, but most suffer from one or more of the following: tissue deformation, tissue destruction, submersion of the tissue in saline, the need for a clear line of site, the inability to detect concavities, or poorly defined cross-sectional perimeters. Molding techniques have been used but have been limited by material issues such as large shrinkages, the inability to capture small detail, or the need to destroy the mold to remove the ligament. In this study, we developed a suitable molding and casting technique without systematic shrinkage that could accurately capture the odd shapes and concavities of foot and ankle ligaments with small clearances between bones. Metal rods of 1.62 mm, 2.90 mm, 3.18 mm, and 9.43 mm in diameter were molded using a liquid silicone rubber and cast with polyurethane. The effect of cutting the mold for specimen removal was investigated, and similar tests were done in the presence of saline. Image analysis software was used to determine the cross-sectional areas from photographs of cut castings. In addition, four different ligaments (each n=5) were dissected, molded, and cast. The cross-sectional area of each ligament was obtained. The maximum difference in area for all cases was 2.00%, with the majority being less than 1.00%; the overall root mean square error was 0.334 mm(2) or 0.97%. Neither cutting the mold for specimen removal nor the presence of saline affected the cross-sectional area of the castings. Various representative foot and ankle ligaments were also molded and cast to capture fine detail of the ligament midsubstance including concavities. We have developed a method of measuring ligament cross-sectional area that can overcome the limitations of other area measurement techniques, while accounting for the complicated anatomy of the bones of the foot. The method was validated using metal rods of known diameters, and a representative set foot ligaments (N=20) was analyzed.


Assuntos
Ligamentos Articulares/anatomia & histologia , Articulação do Tornozelo/anatomia & histologia , Cadáver , Humanos , Ligamentos/anatomia & histologia
15.
Exp Neurol ; 326: 113168, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31904386

RESUMO

Due to the limitation in treatment window of the rtPA (recombinant tissue plasminogen activator), the development of delayed treatment for stroke is needed. We previously reported that there is a difference in neurogenesis and neuroblast migration patterns in different mouse stroke models (proximal and distal middle cerebral artery occlusion models, pMCAo or dMCAo). Specifically, compared to robust neurogenesis and substantial migration of newly born neuroblasts in pMCAo model, dMCAo only illicit limited neurogenesis and migration of neuroblasts towards ischemic area. One potential reason for this difference is the relative location of ischemic area to white matter and the neurogenic niche (subventricular zone, SVZ). Specifically, white matter could serve as a physical barrier or inhibitory factor to neurogenesis and migration in the dMCAo model. Given that a major difference in human and rodent brains is the content of white matter in the brain, in this study, we further characterize these two models and test the important hypothesis that white matter is an important contributing inhibitory factor for the limited neurogenesis in the dMCAo model. We utilized a genetically inducible NSC-specific reporter mouse line (nestin-CreERT2-R26R-YFP) to label and track NSC proliferation, survival and differentiation in ischemic brain. To test whether myelin is inhibitory to neurogenesis in dMCAo model, we demyelinated mouse brains using cuprizone treatment after stroke and examined whether there is enhanced neurogenesis or migration of neuroblasts cells in stroke mice treated with cuprizone. Our data suggests that demyelination of the brain does not result in enhanced neurogenesis or migration of neuroblasts, supporting that myelin is not a major inhibitory factor for stroke-induced neurogenesis. In addition, our results suggest that in non-stroke mice, demyelination causes decreased neurogenesis in adult brain, indicating a potential positive role of myelin in maintenance of adult neural stem cell niche.


Assuntos
Quelantes , Cuprizona , Doenças Desmielinizantes/induzido quimicamente , Doenças Desmielinizantes/patologia , Neurogênese/efeitos dos fármacos , Animais , Comportamento Animal , Isquemia Encefálica/diagnóstico por imagem , Isquemia Encefálica/terapia , Diferenciação Celular/efeitos dos fármacos , Movimento Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Doenças Desmielinizantes/diagnóstico por imagem , Imageamento por Ressonância Magnética , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Células-Tronco Neurais , Acidente Vascular Cerebral/diagnóstico por imagem , Acidente Vascular Cerebral/terapia , Substância Branca/efeitos dos fármacos , Substância Branca/patologia
17.
West J Nurs Res ; 41(8): 1184-1202, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30774036

RESUMO

Tobacco use and exposure to secondhand smoke (SHS) remain leading causes of preventable disease, disability, and mortality in the United States. Rural populations are among those being left behind in the recent declining smoking rates and have become a focus of discussions on tobacco-related disparities. This article describes tobacco-related disparities in rural populations including tobacco use, exposure to SHS, smoke-free policies, and tobacco taxes. Nurses, as social justice and tobacco control policy advocates, are needed especially at the local level, where much of the policy work occurs and where nursing's voice is respected and can be powerful.


Assuntos
Disparidades em Assistência à Saúde , População Rural , Política Antifumo , Impostos/economia , Uso de Tabaco/efeitos adversos , Doença Crônica/prevenção & controle , Humanos , Papel do Profissional de Enfermagem/psicologia , Justiça Social , Inquéritos e Questionários , Poluição por Fumaça de Tabaco/efeitos adversos , Estados Unidos
18.
J Am Heart Assoc ; 8(24): e013939, 2019 12 17.
Artigo em Inglês | MEDLINE | ID: mdl-31795823

RESUMO

Background We evaluated the effects of smoking and smoking cessation on aortic wave reflections (augmentation index), aortic pulse wave velocity, and carotid artery distensibility and stiffness (distensibility coefficient, Young's elastic modulus). Methods and Results Current smokers underwent carotid, radial, and femoral artery tonometry and carotid ultrasound at baseline and 3 years after a quit attempt. Baseline associations of smoking heaviness markers (exhaled carbon monoxide and cigarettes smoked/d) and effects of smoking cessation at year 3 on changes in arterial measures were assessed using multivariable linear regression models. The 1417 smokers (54% female) were mean (SD) 49.3 (11.6) years old and smoked 17.2 (8.3) cigarettes/d (exhaled carbon monoxide 14.7 [8.2] parts per million). Arterial measures were associated more strongly with age, blood pressure (BP), and waist circumference than with smoking heaviness markers. Augmentation index was associated independently with carbon monoxide (P=0.004). Pulse wave velocity, distensibility coefficient, and Young's elastic modulus had small, inconsistent associations with smoking heaviness markers. At year 3, augmentation index improved with smoking cessation (P=0.006) despite more weight gain (2.54 vs 0.36 kg, P<0.001) and insulin resistance (P=0.001) among abstainers, but distensibility coefficient decreased (P=0.004). Changes in arterial measures were related more strongly to changes in BP than smoking cessation. Conclusions Arterial wave reflection and stiffness measures were associated more strongly with age, BP, and waist circumference than smoking heaviness. Smoking cessation was associated with weight gain and increased insulin resistance. Changes in arterial measures were predicted by changes in BP, highlighting the need to address weight gain and BP changes during a quit attempt.


Assuntos
Aorta/fisiopatologia , Artéria Carótida Primitiva/fisiopatologia , Fumar Cigarros/fisiopatologia , Análise de Onda de Pulso , Abandono do Hábito de Fumar , Rigidez Vascular , Adulto , Módulo de Elasticidade , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade
19.
BMJ Qual Saf ; 28(11): 908-915, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31391313

RESUMO

BACKGROUND: To assess the specificity of an algorithm designed to detect look-alike/sound-alike (LASA) medication prescribing errors in electronic health record (EHR) data. SETTING: Urban, academic medical centre, comprising a 495-bed hospital and outpatient clinic running on the Cerner EHR. We extracted 8 years of medication orders and diagnostic claims. We licensed a database of medication indications, refined it and merged it with the medication data. We developed an algorithm that triggered for LASA errors based on name similarity, the frequency with which a patient received a medication and whether the medication was justified by a diagnostic claim. We stratified triggers by similarity. Two clinicians reviewed a sample of charts for the presence of a true error, with disagreements resolved by a third reviewer. We computed specificity, positive predictive value (PPV) and yield. RESULTS: The algorithm analysed 488 481 orders and generated 2404 triggers (0.5% rate). Clinicians reviewed 506 cases and confirmed the presence of 61 errors, for an overall PPV of 12.1% (95% CI 10.7% to 13.5%). It was not possible to measure sensitivity or the false-negative rate. The specificity of the algorithm varied as a function of name similarity and whether the intended and dispensed drugs shared the same route of administration. CONCLUSION: Automated detection of LASA medication errors is feasible and can reveal errors not currently detected by other means. Real-time error detection is not possible with the current system, the main barrier being the real-time availability of accurate diagnostic information. Further development should replicate this analysis in other health systems and on a larger set of medications and should decrease clinician time spent reviewing false-positive triggers by increasing specificity.


Assuntos
Algoritmos , Erros de Medicação/prevenção & controle , Sistemas de Medicação no Hospital/estatística & dados numéricos , Centros Médicos Acadêmicos , Chicago , Bases de Dados Factuais , Prescrições de Medicamentos , Registros Eletrônicos de Saúde , Humanos , Estudos Retrospectivos
20.
SAGE Open Nurs ; 4: 2377960818793033, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-33415203

RESUMO

ABSTRACT AIMS: This study explored the effectiveness of a modified Lifestyle-integrated Functional Exercise program for increasing community-dwelling older adults' lower body strength and balance to decrease fall risk. METHODS: Purposive sampling of men and women aged 65 years and older, with or without a history of falls, living at retirement communities yielded 19 older adult participants, and 16 of the participants completed the 26-week integrated exercise program. The program consisted of five-group training sessions focused on how to integrate individualized exercises into everyday activities, followed by 20 weeks of independent practice with a booster session at Week 10 and two phone calls at Week 15 and Week 20. A battery of assessments was used 3 times to measure the participants. RESULTS: Results demonstrated a significant improvement in lower body strength and balance, but fall risk reduction cannot be confirmed from this study. CONCLUSION: Despite reduction in fall risk was inconclusive from this study, a modified Lifestyle-integrated Functional Exercise program delivered to community-dwelling older adults in a group format may be an effective intervention program to improve lower body strength and balance, while integration of exercises into daily activities may also appear to be more sustainable than traditional exercise program.

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