RESUMO
The brain is subjected to multi-modal sensory information in an environment governed by statistical dependencies. Mismatch responses (MMRs), classically recorded with EEG, have provided valuable insights into the brain's processing of regularities and the generation of corresponding sensory predictions. Only few studies allow for comparisons of MMRs across multiple modalities in a simultaneous sensory stream and their corresponding cross-modal context sensitivity remains unknown. Here, we used a tri-modal version of the roving stimulus paradigm in fMRI to elicit MMRs in the auditory, somatosensory and visual modality. Participants (N = 29) were simultaneously presented with sequences of low and high intensity stimuli in each of the three senses while actively observing the tri-modal input stream and occasionally reporting the intensity of the previous stimulus in a prompted modality. The sequences were based on a probabilistic model, defining transition probabilities such that, for each modality, stimuli were more likely to repeat (p = .825) than change (p = .175) and stimulus intensities were equiprobable (p = .5). Moreover, each transition was conditional on the configuration of the other two modalities comprising global (cross-modal) predictive properties of the sequences. We identified a shared mismatch network of modality general inferior frontal and temporo-parietal areas as well as sensory areas, where the connectivity (psychophysiological interaction) between these regions was modulated during mismatch processing. Further, we found deviant responses within the network to be modulated by local stimulus repetition, which suggests highly comparable processing of expectation violation across modalities. Moreover, hierarchically higher regions of the mismatch network in the temporo-parietal area around the intraparietal sulcus were identified to signal cross-modal expectation violation. With the consistency of MMRs across audition, somatosensation and vision, our study provides insights into a shared cortical network of uni- and multi-modal expectation violation in response to sequence regularities.
Assuntos
Imageamento por Ressonância Magnética , Motivação , Humanos , Estimulação Acústica , Percepção Auditiva/fisiologia , EncéfaloRESUMO
The question how the brain distinguishes between information about self and others is of fundamental interest to both philosophy and neuroscience. In this functional magnetic resonance imaging (fMRI) study, we sought to distinguish the neural substrates of representing a full-body movement as one's movement and as someone else's movement. Participants performed a delayed match-to-sample working memory task where a retained full-body movement (displayed using point-light walkers) was arbitrarily labeled as one's own movement or as performed by someone else. By using arbitrary associations we aimed to address a limitation of previous studies, namely that our own movements are more familiar to us than movements of other people. A searchlight multivariate decoding analysis was used to test where information about types of movement and about self-association was coded. Movement specific activation patterns were found in a network of regions also involved in perceptual processing of movement stimuli, however not in early sensory regions. Information about whether a memorized movement was associated with the self or with another person was found to be coded by activity in the left middle frontal gyrus (MFG), left inferior frontal gyrus (IFG), bilateral supplementary motor area, and (at reduced threshold) in the left temporoparietal junction (TPJ). These areas are frequently reported as involved in action understanding (IFG, MFG) and domain-general self/other distinction (TPJ). Finally, in univariate analysis we found that selecting a self-associated movement for retention was related to increased activity in the ventral medial prefrontal cortex.
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Memória de Curto Prazo , Córtex Motor , Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Mapeamento Encefálico , Humanos , Imageamento por Ressonância Magnética/métodos , Memória de Curto Prazo/fisiologiaRESUMO
Both animal and human studies on numerosity have shown the importance of the parietal cortex for numerosity processing. However, most studies have focused on the perceptual processing of numerosity. Still, it is unclear how and where numerosity information is coded when this information is retained during a working memory delay phase. Such temporal storage could be realized by the same structures as perceptual processes, or be transformed to a more abstract representation, potentially involving prefrontal regions. FMRI decoding studies allow the identification of brain areas that exhibit multi-voxel activation patterns specific to the content of working memory. Here, we used an assumption-free searchlight-decoding approach to test where numerosity-specific codes can be found during a 12 s retention period. Participants (n = 24) performed a retro-cue delayed match-to-sample task, in which numerosity information was presented as visual dot arrays. We found mnemonic numerosity-specific activation in the right lateral portion of the intraparietal sulcus; an area well-known for perceptual processing of numerosity. The applied retro-cue design dissociated working memory delay activity from perceptual processes and showed that the intraparietal sulcus also maintained working memory representation independent of perception.
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Mapeamento Encefálico , Conceitos Matemáticos , Memória de Curto Prazo/fisiologia , Lobo Parietal/fisiologia , Reconhecimento Visual de Modelos/fisiologia , Adulto , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Lobo Parietal/diagnóstico por imagem , Adulto JovemRESUMO
Recent working memory (WM) research has focused on identifying brain regions that retain different types of mental content. Only few neuroimaging studies have explored the mechanism of attention-based refreshing, which is a type of rehearsal and is thought to implement the dynamic components of WM allowing for update of WM contents. Here, we took advantage of the distinct coding properties of the superior parietal lobe (SPL), which retains spatial layout information, and the right inferior frontal gyrus (IFG), which retains frequency information of vibrotactile stimuli during tactile WM. In an fMRI delayed match-to-sample task, participants had to internally rehearse sequences of spatial layouts or vibratory frequencies. Our results replicate the dissociation of SPL and IFG for the retention of layout and frequency information in terms of activation differences between conditions. Additionally, we found strong premotor cortex (PMC) activation during rehearsal of either stimulus type. To explore interactions between these regions we used dynamic causal modeling and found that activation within the network was best explained by a model that allows the PMC to drive activity in the SPL and IFG during rehearsal. This effect was content-specific, meaning that the PMC showed stronger influence on the SPL during pattern rehearsal and stronger influence on the IFG during frequency rehearsal. In line with previously established PMC contributions to sequence processing, our results suggest that it acts as a content-independent area that flexibly recruits content-specific regions to bring a WM item into the focus of attention during the rehearsal of tactile stimulus sequences.
Assuntos
Mapeamento Encefálico , Memória de Curto Prazo/fisiologia , Córtex Motor/fisiologia , Lobo Parietal/fisiologia , Prática Psicológica , Percepção Espacial/fisiologia , Percepção do Tato/fisiologia , Adulto , Feminino , Dedos/fisiologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Córtex Motor/diagnóstico por imagem , Lobo Parietal/diagnóstico por imagem , Córtex Pré-Frontal/diagnóstico por imagem , Córtex Pré-Frontal/fisiologia , Vibração , Adulto JovemRESUMO
Working memory (WM) representations are generally known to be influenced by task demands, but it is not clear whether this extends to the somatosensory domain. One way to investigate the influence of task demands is with categorization paradigms, wherein either a single stimulus or an associated category is maintained in WM. In the somatosensory modality, category representations have been identified in the premotor cortex (PMC) and the intraparietal sulcus (IPS). In this study we used multivariate-pattern-analysis with human fMRI data to investigate whether the WM representations in the PMC, IPS or other regions are influenced by changing task demands. We ensured the task-dependent, categorical WM information was decorrelated from stimulus features by (1) teaching participants arbitrary, non-rule based stimulus groupings and (2) contrasting identical pairs of stimuli across experimental conditions, where either a single stimulus or the associated group was maintained in WM. Importantly, we also decoupled the decision and motor output from the WM representations. With these experimental manipulations, we were able to pinpoint stimulus-specific WM information to the left frontal and parietal cortices and context-dependent, group-specific WM information to the left IPS. By showing that grouped stimuli are represented more similarly in the Group condition than in the Stimulus condition, free from stimulus and motor output confounds, we provide novel evidence for the adaptive nature of somatosensory WM representations in the IPS with changing task-demands.
Assuntos
Adaptação Fisiológica/fisiologia , Mapeamento Encefálico/métodos , Imageamento por Ressonância Magnética/métodos , Memória de Curto Prazo/fisiologia , Lobo Parietal/fisiologia , Córtex Pré-Frontal/fisiologia , Desempenho Psicomotor/fisiologia , Percepção do Tato/fisiologia , Adulto , Estimulação Elétrica , Feminino , Humanos , Masculino , Lobo Parietal/diagnóstico por imagem , Córtex Pré-Frontal/diagnóstico por imagem , Limiar Sensorial/fisiologia , Adulto JovemRESUMO
To understand how the brain handles mentally represented information flexibly in the absence of sensory stimulation, working memory (WM) studies have been essential. A seminal finding in monkey research is that neurons in the prefrontal cortex (PFC) retain stimulus-specific information when vibrotactile frequencies were memorized. A direct mapping between monkey studies and human research is still controversial. Although oscillatory signatures, in terms of frequency-dependent parametric beta-band modulation, have been observed recently in human EEG studies, the content specificity of these representations in terms of multivariate pattern analysis has not yet been shown. Here, we used fMRI in combination with multivariate classification techniques to determine which brain regions retain information during WM. In a retro-cue delayed-match-to-sample task, human subjects memorized the frequency of vibrotactile stimulation over a 12 s delay phase. Using an assumption-free whole-brain searchlight approach, we tested with support vector regression which brain regions exhibited multivariate parametric WM codes of the maintained frequencies during the WM delay. Interestingly, our analysis revealed an overlap with regions previously identified in monkeys composed of bilateral premotor cortices, supplementary motor area, and the right inferior frontal gyrus as part of the PFC. Therefore, our results establish a link between the WM codes found in monkeys and those in humans and emphasize the importance of the PFC for information maintenance during WM also in humans.SIGNIFICANCE STATEMENT Working memory (WM) research in monkeys has identified a network of regions, including prefrontal regions, to code stimulus-specific information when vibrotactile frequencies are memorized. Here, we performed an fMRI study during which human subjects had to memorize vibratory frequencies in parallel to previous monkey research. Using an assumption-free, whole-brain searchlight decoding approach, we identified for the first time regions in the human brain that exhibit multivariate patterns of activity to code the vibratory frequency parametrically during WM. Our results parallel previous monkey findings and show that the supplementary motor area, premotor, and the right prefrontal cortex are involved in vibrotactile WM coding in humans.
Assuntos
Memória de Curto Prazo/fisiologia , Córtex Pré-Frontal/fisiologia , Desempenho Psicomotor/fisiologia , Tato/fisiologia , Vibração , Adulto , Comportamento de Escolha/fisiologia , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Estimulação Luminosa/métodos , Estimulação Física/métodos , Córtex Pré-Frontal/diagnóstico por imagem , Adulto JovemRESUMO
Working memory (WM) studies have been essential for ascertaining how the brain flexibly handles mentally represented information in the absence of sensory stimulation. Most studies on the memory of sensory stimulus features have focused, however, on the visual domain. Here, we report a human WM study in the tactile modality where participants had to memorize the spatial layout of patterned Braille-like stimuli presented to the index finger. We used a whole-brain searchlight approach in combination with multi-voxel pattern analysis (MVPA) to investigate tactile WM representations without a priori assumptions about which brain regions code tactospatial information. Our analysis revealed that posterior and parietal cortices, as well as premotor regions, retained information across the twelve-second delay phase. Interestingly, parts of this brain network were previously shown to also contain information of visuospatial WM. Also, by specifically testing somatosensory regions for WM representations, we observed content-specific activation patterns in primary somatosensory cortex (SI). Our findings demonstrate that tactile WM depends on a distributed network of brain regions in analogy to the representation of visuospatial information.
Assuntos
Mapeamento Encefálico/métodos , Encéfalo/fisiologia , Memória de Curto Prazo/fisiologia , Percepção do Tato/fisiologia , Adulto , Feminino , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/métodos , Masculino , Estimulação Física , Máquina de Vetores de Suporte , Adulto JovemRESUMO
Brain activity in frontal regions has been found to represent frequency information with a parametric code during working memory delay phases. The mental representation of frequencies has furthermore been shown to be modality independent in non-human primate electrophysiology and human EEG studies, suggesting frontal regions encoding quantitative information in a supramodal manner. A recent fMRI study using multivariate pattern analysis (MVPA) supports an overlapping multimodal network for the maintenance of visual and tactile frequency information over frontal and parietal brain regions. The present study extends the investigation of working memory representation of frequency information to the auditory domain. To this aim, we used MVPA on fMRI data recorded during an auditory frequency maintenance task. A support vector regression analysis revealed working memory information in auditory association areas and, consistent with earlier findings of parametric working memory, in a frontoparietal network. A direct comparison to an analogous dataset of vibrotactile parametric working memory revealed an overlap of information coding in prefrontal regions, particularly in the right inferior frontal gyrus. Therefore, our findings indicate that the prefrontal cortex represents frequency-specific working memory content irrespective of the modality as has been now also revealed for the auditory modality.
Assuntos
Percepção Auditiva/fisiologia , Mapeamento Encefálico/métodos , Imageamento por Ressonância Magnética/métodos , Memória de Curto Prazo/fisiologia , Córtex Pré-Frontal/fisiologia , Percepção do Tato/fisiologia , Adulto , Feminino , Humanos , Masculino , Córtex Pré-Frontal/diagnóstico por imagem , Adulto JovemRESUMO
Previous working memory (WM) research based on non-human primate electrophysiology and human EEG has shown that frontal brain regions maintain frequencies of flutter stimulation across different sensory modalities by means of a supramodal parametric WM code. These findings imply that frontal regions encode the memorized frequencies in a sensory-unspecific, quantitative format. Here, we explored which brain regions maintain information about frequencies provided by different sensory modalities at the level of activity pattern across fMRI voxel populations. Moreover, we sought evidence for a supramodal multivariate WM representation. Participants maintained the same set of frequencies of tactile vibration and visual flicker for a 6 s WM delay in a frequency discrimination task. A support vector regression model for multivariate pattern analysis was applied. We observed that sensory cortices were only selective for memoranda of their corresponding modalities, while frontoparietal regions exhibited distinguishable activity patterns to memorized frequencies regardless of sensory modality. A common multivariate code was not evident in our data. Collectively, we show that mnemonic representations for stimulus frequencies are maintained throughout the cortical hierarchy, in line with the suggested transformation of information across different representational formats. Although evidence for a supramodal multivariate code is absent, our findings underpin the generalized role of the frontoparietal cortex for maintaining quantitative information across sensory modalities.
Assuntos
Mapeamento Encefálico/métodos , Lobo Frontal/fisiologia , Memória de Curto Prazo/fisiologia , Lobo Parietal/fisiologia , Reconhecimento Visual de Modelos/fisiologia , Desempenho Psicomotor/fisiologia , Percepção do Tato/fisiologia , Adulto , Feminino , Lobo Frontal/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Masculino , Lobo Parietal/diagnóstico por imagem , Adulto JovemRESUMO
Constructing mental representations in the absence of sensory stimulation is a fundamental ability of the human mind and has been investigated in numerous brain imaging studies. However, it is still unclear how brain areas facilitating mental construction processes interact with brain regions related to specific sensory representations. In this fMRI study subjects formed mental representations of tactile stimuli either from memory (imagery) or from presentation of actual corresponding vibrotactile patterned stimuli. First our analysis addressed the question of whether tactile imagery recruits primary somatosensory cortex (SI), because the activation of early perceptual areas is classically interpreted as perceptual grounding of the mental image. We also tested whether a network, referred to as 'core construction system', is involved in the generation of mental representations in the somatosensory domain. In fact, we observed imagery-induced activation of SI. We further found support for the notion of a modality independent construction network with the retrosplenial cortices and the precuneus as core components, which were supplemented with the left inferior frontal gyrus (IFG). Finally, psychophysiological interaction (PPI) analyses revealed robust imagery-modulated changes in the connectivity of these construction related areas, which suggests that they orchestrate the assembly of an abstract mental representation. Interestingly, we found increased coupling between prefrontal cortex (left IFG) and SI during mental imagery, indicating the augmentation of an abstract mental representation by reactivating perceptually grounded sensory details.
Assuntos
Imaginação/fisiologia , Córtex Pré-Frontal/fisiologia , Córtex Somatossensorial/fisiologia , Percepção do Tato/fisiologia , Adulto , Mapeamento Encefálico , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Vias Neurais/fisiologia , Adulto JovemRESUMO
Flicker light stimulation (FLS) is a non-pharmacological method of inducing altered states of consciousness (ASCs), producing hallucination-like phenomena as well as effects extending beyond the visual modality, including emotional effects. Research into the psychological and neural mechanisms of FLS is still in its infancy, but can be informed by research into other methods of inducing ASCs. For instance, research on classic psychedelics has reported enhancement of emotional responses to music. Here, we test to what degree FLS might also enhance the emotional response to music, using a study protocol designed to resemble a previous study on the effects of LSD as closely as possible, to allow for comparison of effect sizes across modalities and inform future research into FLS as an ASC-induction method. Twenty participants listened to emotionally evocative music in two conditions - with and without FLS - and reported on their emotional response to the music. FLS showed a significant enhancing effect on reported music-evoked emotion, especially emotions relating to "Joyful Activation"; additionally, we found that the experienced intensity of FLS correlated with reports of higher levels of emotional arousal. These findings motivate further research into FLS as a method for inducing ASCs and into the interactions between visual phenomena and music-evoked emotion.
RESUMO
Background: Classic serotonergic psychedelics have anecdotally been reported to show a characteristic pattern of subacute effects that persist after the acute effects of the substance have subsided. These transient effects, sometimes labeled as the 'psychedelic afterglow', have been suggested to be associated with enhanced effectiveness of psychotherapeutic interventions in the subacute period. Objectives: This systematic review provides an overview of subacute effects of psychedelics. Methods: Electronic databases (MEDLINE, Web of Science Core Collection) were searched for studies that assessed the effects of psychedelics (LSD, psilocybin, DMT, 5-MeO-DMT, mescaline, or ayahuasca) on psychological outcome measures and subacute adverse effects in human adults between 1950 and August 2021, occurring between 1 day and 1 month after drug use. Results: Forty-eight studies including a total number of 1,774 participants were eligible for review. Taken together, the following subacute effects were observed: reductions in different psychopathological symptoms; increases in wellbeing, mood, mindfulness, social measures, spirituality, and positive behavioral changes; mixed changes in personality/values/attitudes, and creativity/flexibility. Subacute adverse effects comprised a wide range of complaints, including headaches, sleep disturbances, and individual cases of increased psychological distress. Discussion: Results support narrative reports of a subacute psychedelic 'afterglow' phenomenon comprising potentially beneficial changes in the perception of self, others, and the environment. Subacute adverse events were mild to severe, and no serious adverse events were reported. Many studies, however, lacked a standardized assessment of adverse effects. Future studies are needed to investigate the role of possible moderator variables and to reveal if and how positive effects from the subacute window may consolidate into long-term mental health benefits.
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Flicker light stimulation (FLS) uses stroboscopic light on closed eyes to induce transient visual hallucinatory phenomena, such as the perception of geometric patterns, motion, and colours. It remains an open question where the neural correlates of these hallucinatory experiences emerge along the visual pathway. To allow future testing of suggested underlying mechanisms (e.g., changes in functional connectivity, neural entrainment), we sought to systematically characterise the effects of frequency (3 Hz, 8 Hz, 10 Hz and 18 Hz) and rhythmicity (rhythmic and arrhythmic conditions) on flicker-induced subjective experiences. Using a novel questionnaire, we found that flicker frequency and rhythmicity significantly influenced the degree to which participants experienced simple visual hallucinations, particularly the perception of Klüver forms and dynamics (e.g., motion). Participants reported their experience of geometric patterns and dynamics was at highest intensity during 10 Hz rhythmic stimulation. Further, we found that frequency-matched arrhythmic FLS strongly reduced these subjective effects compared to equivalent rhythmic stimulation. Together, these results provide evidence that flicker rhythmicity critically contributes to the effects of FLS beyond the effects of frequency alone, indicating that neural entrainment may drive the induced phenomenal experience.
Assuntos
Alucinações , Humanos , Estimulação Luminosa/métodosRESUMO
Several measures have been designed to assess subjective experiences induced by psychedelic substances or other mind-altering drugs as well as non-pharmacological methods. Recently, two self-report questionnaires have been introduced to measure acute adverse effects following psilocybin ingestion and the phenomenon of ego-dissolution associated with the use of psychedelics, respectively. The 26-item Challenging Experience Questionnaire assesses multiple facets of psilocybin induced experiences on seven subscales, whereas the 8-item Ego-Dissolution Inventory consists of a unidimensional scale. In the present study, these questionnaires were translated into German and their psychometric properties then evaluated in an online survey on psychedelics induced experiences. Confirmatory factor analysis suggested an acceptable fit of the 7-factor structure of the German Challenging Experience Questionnaire with overall good internal consistency for all subscales. The factor structure did not differ based on gender or prior struggle with a psychiatric disorder, furthering the evidence of internal validity. Correlations with the State-Trait-Anxiety Inventory and the Altered States of Consciousness Rating Scale demonstrated convergent validity. Confirmatory factor analysis did not support the hypothesized single-factor structure of the German Ego-Dissolution Inventory and exploratory factor analysis suggested an alternative factor structure, where only five items loaded onto a common factor that was interpreted as ego-dissolution. Internal consistency of this 5-item measure was high and correlation with selected items of the Mystical Experience Questionnaire and Altered States of Consciousness Rating Scale supported convergent validity. Translation and validation of these questionnaires contribute to the advancement of common standards in the psychological and neuroscientific study of altered states of consciousness.
Assuntos
Alucinógenos , Ego , Alucinógenos/farmacologia , Humanos , Psilocibina , Psicometria/métodos , Reprodutibilidade dos Testes , Solubilidade , Inquéritos e QuestionáriosRESUMO
Body perception has been extensively investigated, with one particular focus being the integration of vision and touch within a neuronal body representation. Previous studies have implicated a distributed network comprising the extrastriate body area (EBA), posterior parietal cortex (PPC) and ventral premotor cortex (PMv) during illusory self-attribution of a rubber hand. Here, we set up an fMRI paradigm in virtual reality (VR) to study whether and how the self-attribution of (artificial) body parts is altered if these body parts are somehow threatened. Participants (N = 30) saw a spider (aversive stimulus) or a toy-car (neutral stimulus) moving along a 3D-rendered virtual forearm positioned like their real forearm, while tactile stimulation was applied on the real arm in the same (congruent) or opposite (incongruent) direction. We found that the PPC was more activated during congruent stimulation; higher visual areas and the anterior insula (aIns) showed increased activation during aversive stimulus presentation; and the amygdala was more strongly activated for aversive stimuli when there was stronger multisensory integration of body-related information (interaction of aversiveness and congruency). Together, these findings suggest an enhanced processing of aversive stimuli within the amygdala when they represent a bodily threat.
Assuntos
Membros Artificiais , Ilusões , Percepção do Tato , Tonsila do Cerebelo/diagnóstico por imagem , Humanos , Ilusões/fisiologia , Estimulação Luminosa , Percepção do Tato/fisiologia , Percepção Visual/fisiologiaRESUMO
Flicker light stimulation can induce short-term alterations in consciousness including hallucinatory color perception and geometric patterns. In the study at hand, the subjective experiences during 3 Hz and 10 Hz stroboscopic light stimulation of the closed eyes were assessed. In a within-subjects design (N = 24), we applied the Positive and Negative Affect Schedule (mood state), time perception ratings, the Altered State of Consciousness Rating Scale, and the Phenomenology of Consciousness Inventory. Furthermore, we tested for effects of personality traits (NEO Five-Factor Inventory-2 and Tellegen Absorption Scale) on subjective experiences. Such systematic quantification improves replicability, facilitates comparisons between pharmacological and non-pharmacological techniques to induce altered states of consciousness, and is the prerequisite to study their underlying neuronal mechanisms. The resulting data showed that flicker light stimulation-induced states were characterized by vivid visual hallucinations of simple types, with effects strongest in the 10 Hz condition. Additionally, participants' personality trait of Absorption scores highly correlated with the experienced alterations in consciousness. Our data demonstrate that flicker light stimulation is capable of inducing visual effects with an intensity rated to be similar in strength to effects induced by psychedelic substances and thereby support the investigation of potentially shared underlying neuronal mechanisms.
Assuntos
Estado de Consciência/efeitos da radiação , Alucinações/fisiopatologia , Estimulação Luminosa/efeitos adversos , Percepção Visual/efeitos da radiação , Adolescente , Adulto , Encéfalo/fisiologia , Encéfalo/efeitos da radiação , Percepção de Cores/fisiologia , Percepção de Cores/efeitos da radiação , Estado de Consciência/fisiologia , Eletroencefalografia , Feminino , Alucinações/etiologia , Voluntários Saudáveis , Humanos , Luz/efeitos adversos , Masculino , Estimulação Luminosa/métodos , Percepção do Tempo/fisiologia , Percepção do Tempo/efeitos da radiação , Percepção Visual/fisiologia , Adulto JovemRESUMO
Estimated numerosity perception is processed in an approximate number system (ANS) that resembles the perception of a continuous magnitude. The ANS consists of a right lateralized frontoparietal network comprising the lateral prefrontal cortex (LPFC) and the intraparietal sulcus. Although the ANS has been extensively investigated, only a few studies have focused on the mental representation of retained numerosity estimates. Specifically, the underlying mechanisms of estimated numerosity working memory (WM) is unclear. Besides numerosities, as another form of abstract quantity, vibrotactile WM studies provide initial evidence that the right LPFC takes a central role in maintaining magnitudes. In the present fMRI multivariate pattern analysis study, we designed a delayed match-to-numerosity paradigm to test what brain regions retain approximate numerosity memoranda. In line with parametric WM results, our study found numerosity-specific WM representations in the right LPFC as well as in the supplementary motor area and the left premotor cortex extending into the superior frontal gyrus, thus bridging the gap in abstract quantity WM literature.
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Mapeamento Encefálico , Memória de Curto Prazo , Lobo Parietal , Humanos , Imageamento por Ressonância Magnética , Lobo Parietal/diagnóstico por imagem , Córtex Pré-Frontal/diagnóstico por imagem , TatoRESUMO
Kambô, the secretion of the Amazonian Giant Leaf Frog (Phyllomedusa bicolor) contains a plethora of bioactive peptides and was originally used by indigenous communities from the Amazon basin as medicine for improving hunting capacities. In the last 20 years, Kambô has spread to Western urban healing circles. To date it is still controversial whether the acute effects of Kambô include alterations of consciousness similar to known psychoactive substance like serotonergic psychedelics. Here we retrospectively assessed psychological effects of Kambô in a sample of anonymous users (n = 22, mean age: 39 years, ± 8.5; 45.5% female), administering standardized questionnaires for the assessment of altered states of consciousness (ASC), including the Altered States of Consciousness Rating Scale, the Phenomenology of Consciousness Inventory (PCI), the Mystical Experience Questionnaire (MEQ), the Challenging Experience Questionnaire (CEQ) for acute effects and the Persisting Effects Questionnaire (PEQ) and a scale assessing connectedness for subacute effects. The intensity of retrospectively reported acute psychological effects remained on a mild to moderate level, with no psychedelic-type distortions of perception or thinking. Conversely, persisting effects were predominantly described as positive and pleasant, revealing high scores on measures of personal and spiritual significance.
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Estado de Consciência/efeitos dos fármacos , Emoções/efeitos dos fármacos , Alucinógenos/farmacologia , Neuropeptídeos/farmacologia , Adulto , Animais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ranidae , Estudos RetrospectivosRESUMO
Different pharmacologic agents have been used to investigate the neuronal underpinnings of alterations in consciousness states, such as psychedelic substances. Special attention has been drawn to the role of thalamic filtering of cortical input. Here, we investigate the neuronal mechanisms underlying an altered state of consciousness (ASC) induced by a non-pharmacological procedure. During fMRI scanning, N = 19 human participants were exposed to multimodal Ganzfeld stimulation, a technique of perceptual deprivation where participants are exposed to intense, unstructured, homogenous visual and auditory stimulation. Compared to pre- and post-resting-state scans, the Ganzfeld data displayed a progressive decoupling of the thalamus from the cortex. Furthermore, the Ganzfeld-induced ASC was characterized by increased eigenvector centrality in core regions of the default mode network (DMN). Together, these findings can be interpreted as an imbalance of sensory bottom-up signaling and internally-generated top-down signaling. This imbalance is antithetical to psychedelic-induced ASCs, where increased thalamo-cortical coupling and reduced DMN activity were observed.
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Córtex Cerebral/fisiologia , Transtornos da Consciência , Tálamo/fisiologia , Adulto , Córtex Cerebral/diagnóstico por imagem , Eletroencefalografia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Estudos Retrospectivos , Tálamo/diagnóstico por imagem , Adulto JovemRESUMO
To what degree mental imagery (MI) bears on the same neuronal processes as perception has been a central question in the neurophysiological study of imagery. Sensory-recruitment models suggest that imagery of sensory material heavily relies on the involvement of sensory cortices. Empirical evidence mainly stems from the study of visual imagery and suggests that it depends on the mentally imagined material whether hierarchically lower regions are recruited. However, evidence from other modalities is necessary to infer generalized principles. In this fMRI study we used the somatotopic organization of the primary somatosensory cortex (SI) to test in how far MI of tactile sensations activates topographically sensory brain areas. Participants (N = 19) either perceived or imagined vibrotactile stimuli on their left or right thumbs or big toes. The direct comparison to a corresponding perception condition revealed that SI was somatotopically recruited during imagery. While stimulus driven bottom-up processing induced activity throughout all SI subareas, i.e., BA1, BA3a, BA3b, and BA2 defined by probabilistic cytoarchitectonic maps, top-down recruitment during imagery was limited to the hierarchically highest subarea BA2.