Effect of frozen storage on dynamic tensile properties of human placenta.

Dynamic mechanical properties of placenta tissue are needed to develop computational models of pregnant occupants for use in designing restraint systems that protect the fetus and mother. Tests were performed on 21 samples obtained from five human placentas at a rate of 1200 %/s using a set of custom designed thermoelectrically cooled clamps. Approximately half of the samples from all five subjects were tested within 48 h of delivery. The remaining samples were frozen for 5-7 days and then thawed before testing. True failure stresses and strains were not significantly different between fresh and frozen samples (p-value = 0.858 and 0.551, respectively), suggesting that soft tissue may be stored frozen up to a week without adversely affecting dynamic material response.

RESNA's position on wheelchairs used as seats in motor vehicles.

This position paper is based on the premise that those who ride seated in wheelchairs are entitled to equivalent occupant safety when they are traveling in motor vehicles. The document summarizes research and best practice for safety and selection of crashworthy wheelchairs with the requisite features required by the WC19 safety standard when it is necessary for individuals to use a wheelchair as a seat in a motor vehicle. Recommendations are based on data from accident and injury databases, prior research and a synopsis of the design, testing, performance and labeling requirements of ANSI and ISO voluntary industry standards for wheelchair transportation safety. This paper is intended for an audience of consumers, rehabilitation and health care professionals, manufacturers of wheelchairs and wheelchair transportation equipment and those who make reimbursement and public policy decisions.

Should airbags be deactivated for wheelchair-seated drivers?

OBJECTIVE: Field data have shown significant benefit from driver airbag for occupant protection in frontal crashes. However, vehicle modifiers almost always permanently deactivate airbags for wheelchair-seated drivers. The objective of this study was to conduct sled tests and computational simulations to answer whether driver airbags should be deactivated for drivers seated in wheelchairs. METHODS: Five sled tests were conducted under a 48-kph 20-g frontal crash pulse all with driver airbag. Seat-belt fit (good, poor, and unbelted), airbag deployment time (proper and late), and occupant size (midsize male and small female HIII ATDs) were varied in the tests. The 2006 Chrysler Town-and-Country minivan was selected as the nominal vehicle environment, and a surrogate wheelchair with a docking securement system was used for all sled tests. ATD injury measures for the head, neck, chest, and lower extremities were recorded in each test, and were used for validating a set of MADYMO models. Parametric studies with a total of 28 MADYMO simulations were then conducted to investigate the airbag effects on occupant injury risks with varied occupant size, belt fit, and impact angle (0, 15, and 30 deg). RESULTS: The sled tests showed potential safety concerns for wheelchair-seated drivers with a poor belt fit or without a belt. Specifically, the unbelted midsize male ATD sustained high femur forces and the small female ATD with poor belt fit sustained high chest deflections. The parametric simulations showed that airbag generally improved the protection for wheelchair-seated drivers. It is especially useful for unbelted wheelchair-seated drivers, and is also helpful for reducing the head and neck injury risks regardless of the belt condition, occupant size, and impact angle. CONCLUSIONS: This is the first study using sled tests and computational simulations to investigate the effects of airbag deployment on injury risks of wheelchair-seated drivers. Overall, the results showed little basis for concern that the energy of deploying a driver airbag in today's vehicles will cause serious-to-fatal injuries to drivers seated in wheelchairs. The results of this study therefore support the idea that driver airbags generally offer tangible safety benefits for a wide range of wheelchair-seated drivers in frontal crashes.

Fetal outcome in motor-vehicle crashes: effects of crash characteristics and maternal restraint.

OBJECTIVE: This project was undertaken to improve understanding of factors associated with adverse fetal outcomes of pregnant occupants involved in motor-vehicle crashes. STUDY DESIGN: In-depth investigations of crashes involving 57 pregnant occupants were performed. Maternal and fetal injuries, restraint information, measures of external and internal vehicle damage, and details about the crash circumstances were collected. Crash severity was calculated using vehicle crush measurements. Chi-square analysis and logistic regression models were used to determine factors with a significant association with fetal outcome. RESULTS: Fetal outcome is most strongly associated with crash severity (P < .001) and maternal injury (P = .002). Proper maternal belt-restraint use (with or without airbag deployment) is associated with acceptable fetal outcome (odds ratio = 4.5, P = .033). Approximately half of fetal losses in motor-vehicle crashes could be prevented if all pregnant women properly wore seat belts. CONCLUSION: Higher crash severity, more severe maternal injury, and lack of proper seat belt use are associated with a higher risk of adverse fetal outcome. These results strongly support recommendations that pregnant women use properly positioned seatbelts.

Transportation safety standards for wheelchair users: a review of voluntary standards for improved safety, usability, and independence of wheelchair-seated travelers.

Safe transportation for wheelchair users who do not transfer to the vehicle seat when traveling in motor vehicles requires after-market wheelchair tiedown and occupant restraint systems (WTORS) to secure the wheelchair and provide crashworthy restraint for the wheelchair-seated occupant. In the absence of adequate government safety standards, voluntary standards for the design and performance of WTORS, and for wheelchairs used as seats in motor vehicles, have been developed. The initial versions of these standards qualify equipment for use in all types and sizes of motor vehicles using a 30-mph (48-kph), 20-g frontal sled-impact test. The wheelchair standard requires four accessible, crash-tested securement points on wheelchairs so they can be more easily and effectively secured using a four-point strap-type tie-down system. Future voluntary standards are aimed at reducing injury risk for wheelchair-seated occupants in rear impacts and at providing a method for evaluating the crashworthiness of wheelchair seating systems independent of wheelchair base-frames. They also address improved usability and independence for wheelchair-seated travelers using public transportation by specifying universal docking interface geometry for wheelchairs and design and performance requirements for rear-facing wheelchair passenger stations for use in the very low-g environments of large fixed-route transit buses.

Validation of a parametric finite element human femur model.

OBJECTIVE: Finite element (FE) models with geometry and material properties that are parametric with subject descriptors, such as age and body shape/size, are being developed to incorporate population variability into crash simulations. However, the validation methods currently being used with these parametric models do not assess whether model predictions are reasonable in the space over which the model is intended to be used. This study presents a parametric model of the femur and applies a unique validation paradigm to this parametric femur model that characterizes whether model predictions reproduce experimentally observed trends. METHODS: FE models of male and female femurs with geometries that are parametric with age, femur length, and body mass index (BMI) were developed based on existing statistical models that predict femur geometry. These parametric FE femur models were validated by comparing responses from combined loading tests of femoral shafts to simulation results from FE models of the corresponding femoral shafts whose geometry was predicted using the associated age, femur length, and BMI. The effects of subject variables on model responses were also compared with trends in the experimental data set by fitting similarly parameterized statistical models to both the results of the experimental data and the corresponding FE model results and then comparing fitted model coefficients for the experimental and predicted data sets. RESULTS: The average error in impact force at experimental failure for the parametric models was 5%. The coefficients of a statistical model fit to simulation data were within one standard error of the coefficients of a similarly parameterized model of the experimental data except for the age parameter, likely because material properties used in simulations were not varied with specimen age. In simulations to explore the effects of femur length, BMI, and age on impact response, only BMI significantly affected response for both men and women, with increasing BMI producing higher impact forces. CONCLUSIONS: Impactor forces from simulations, on average, matched experimental values at the time of failure. In addition, the simulations were able to match the trends in the experimental data set.

The effects of tethering rear -facing child restraint systems on ATD responses.

A series of sled tests was performed to analyze the responses of an anthropomorphic test device (ATD), particularly neck forces, when rear-facing child restraint systems (CRS) are tethered. Nominally identical rear-facing CRS were tested in four tether conditions: untethered, tethered down to the floor, tethered down to the bottom of the vehicle seat, and tethered rearward to a point above the back of the vehicle seat. The CRABI 12MO ATD with head, upper neck, and chest instrumentation was used in all tests. The tests were conducted using the ECE R44.02 test bench. Both frontal and rear impacts were performed and each condition was repeated for a total of 16 sled tests. Motions of the CRS and ATD were recorded using high-speed digital video (1000 fps). The highest ATD accelerations, forces, and moments were observed during the primary impact of a frontal test, rather than on rebound. The loads observed during rebound from frontal impact were similar in magnitude to the peak loads collected during rear impact. The four tethering geometries produced distinct loading patterns. The lowest HIC, neck forces, and chest accelerations in both impact directions were observed with the rearward tether. The upper neck moment data did not show a clear trend relative to tethering geometry. ATD and CRS motions were best controlled in frontal impact by the rearward tethering geometry while the motions in rear impact were best controlled by tethering to the floor. The data show a potential benefit in both frontal and rear impacts of tethering rear-facing CRS to a point above the vehicle seatback.

Injuries to the hip joint in frontal motor-vehicle crashes: biomechanical and real-world perspectives.

Hip fractures and dislocations in frontal crashes are of substantial concern to clinicians and automotive safety engineers because of the frequency at which hip injuries occur and the associated potential for long-term disability. Impacts to the flexed knees of unembalmed cadavers under loading conditions similar to those that occur in frontal crashes of newer-model vehicles indicate that the hip is the weakest part of the knee-thigh-hip complex and that hip injury tolerance is reduced by hip flexion and adduction from a typical driving posture. These results are being used to develop new knee-thigh-hip injury assessment criteria for use in anthropomorphic test devices (crash test dummies).

Response and Tolerance of Female and/or Elderly PMHS to Lateral Impact.

Eight whole fresh-frozen cadavers (6 female, 2 male) that were elderly and/or female were laterally impacted using UMTRI's dual-sled side-impact test facility. Cadavers were not excluded on the basis of old age or bone diseases that affect tolerance. A thinly padded, multi-segment impactor was used that independently measured force histories applied to the shoulder, thorax, abdomen, greater trochanter, iliac wing, and femur of each PMHS. Impactor plates were adjusted vertically and laterally toward the subject so that contact with body regions occurred simultaneously and so that each segment contacted the same region on every subject. This configuration minimized the effects of body shape on load sharing between regions. Prior to all tests, cadavers were CT scanned to check for pre-existing skeletal injuries. Cadavers were excluded if they had preexisting rib fractures or had undergone CPR. Cadavers were instrumented with strain gages at the posterolateral, lateral, and anterolateral portions of the struck-side ribs, and chestbands were positioned on the upper and lower thorax. Cadavers were first impacted at 3 m/s. If two or fewer rib fractures occurred, as determined using strain gage data and a post-test CT scan, a second impact was performed at 6 m/s on the contralateral side of the body. Five of the eight 3-m/s tests produced AIS 3+ level injuries. All three of the 6-m/s tests produced AIS 3+ injury. Response corridors were developed for each body region using the Maltese alignment method with impulse-momentum normalization. Corridors describing upper and lower thorax deflection were generated from chestband data. An injury risk curve developed from the deflections associated with AIS 3+ injury associates a 50% probability of AIS 3+ rib fracture with 25.6% half-thorax deflection for the population used in this study.

Biomechanical considerations for assessing interactions of children and small occupants with inflatable seat belts.

NHTSA estimates that more than half of the lives saved (168,524) in car crashes between 1960 and 2002 were due to the use of seat belts. Nevertheless, while seat belts are vital to occupant crash protection, safety researchers continue efforts to further enhance the capability of seat belts in reducing injury and fatality risk in automotive crashes. Examples of seat belt design concepts that have been investigated by researchers include inflatable, 4-point, and reverse geometry seat belts. In 2011, Ford Motor Company introduced the first rear seat inflatable seat belts into production vehicles. A series of tests with child and small female-sized Anthropomorphic Test Devices (ATD) and small, elderly female Post Mortem Human Subjects (PMHS) was performed to evaluate interactions of prototype inflatable seat belts with the chest, upper torso, head and neck of children and small occupants, from infants to young adolescents. Tests simulating a 6-year-old child asleep in a booster seat, with its head lying directly on its shoulder on top of the inflatable seat belt, were considered by engineering judgment, to represent a worst case scenario for interaction of an inflating seat belt with the head and neck of a child and/or small occupant. All evaluations resulted in ATD responses below Injury Assessment Reference Values reported by Mertz et al. (2003). In addition, the tests of the PMHS subjects resulted in no injuries from interaction of the inflating seat belt with the heads, necks, and chests of the subjects. Given the results from the ATD and PMHS tests, it was concluded that the injury risk to children and small occupants from deployment of inflatable seat belt systems is low.

PMHS impact response in 3 m/s and 8 m/s nearside impacts with abdomen offset.

Lateral impact tests were performed using seven male post-mortem human subjects (PMHS) to characterize the force-deflection response of contacted body regions, including the lower abdomen. All tests were performed using a dual-sled, side-impact test facility. A segmented impactor was mounted on a sled that was pneumatically accelerated into a second, initially stationary sled on which a subject was seated facing perpendicular to the direction of impact. Positions of impactor segments were adjusted for each subject so that forces applied to different anatomic regions, including thorax, abdomen, greater trochanter, iliac wing, and thigh, could be independently measured on each PMHS. The impactor contact surfaces were located in the same vertical plane, except that the abdomen plate was offset 5.1 cm towards the subject. The masses of the sleds and the force- deflection characteristics of the energy-absorbing interface material between the sleds were set to provide the impactor sled with a velocity profile that matched the average driver door velocity history produced in a series of side NCAP tests. Impactor padding was also selected so that average ATD pelvis and thorax responses from the same series of side NCAP tests were reproduced when the ATD used in these tests was impacted using the average door-velocity history. Each subject was first impacted on one side of the body using an initial impactor speed of 3 m/s. If a post-test CT scan and strain-gage data revealed two or fewer non-displaced rib fractures, then the PMHS was impacted on the contralateral side of the body at a speed of 8 m/s or 10 m/s. The results of tests in the 3 m/s and 8 m/s conditions were used to develop force-deflection response corridors for the abdomen, force history response corridors for the pelvis (iliac wing and greater trochanter), the midthigh, and the thorax. Response corridors for the lateral acceleration of the pelvis were also developed. Future work will compare side impact ATD responses to these response corridors.

Descriptions of motor vehicle collisions by participants in emergency department-based studies: are they accurate?

INTRODUCTION: We examined the accuracy of research participant characterizations of motor vehicle collisions (MVC). METHODS: We conducted an emergency department-based prospective study of adults presenting for care after experiencing an MVC. Study participants completed a structured clinical interview that assessed the number of lanes of the road where the collision took place, vehicle type, road condition, speed limit, seat belt use, airbag deployment, vehicle damage, time of collision, and use of ambulance transportation. Study participant data were then compared with information recorded by Michigan State Police at the scene of the MVC. Agreement between research participant reports and police-reported data were assessed by using percentage agreement and κ coefficients for categorical variables and correlation coefficients for continuous variables. RESULTS: There were 97 study participants for whom emergency department interviews and Michigan State Police Report information were available. Percentage agreement was 51% for number of lanes, 76% for car drivability, 88% for road condition, 91% for vehicle type, 92% for seat belt use, 94% for airbag deployment, 96% for speed limit, 97% for transportation by ambulance, and 99% for vehicle seat position. κ values were 0.32 for seat belt use, 0.34 for number of lanes, 0.73 for vehicle type, 0.76 for speed limit, 0.77 for road condition, 0.87 for airbag deployment, 0.90 for vehicle seat position, and 0.94 for transport by ambulance. Correlation coefficients were 0.95 for the time of the collision, and 0.58 for extent of damage to the vehicle. Most discrepancies between patients and police about extent of vehicle damage occurred for cases in which the patient reported moderate or severe damage but the police reported only slight damage. CONCLUSION: For most MVC characteristics, information reported by research participants was consistent with police-reported data. Agreement was moderate or high for characteristics of greatest relevance to injury biomechanics. These results suggest that research participant report is an acceptable source of collision information.

Applying basic principles of child passenger safety to improving transportation safety for children who travel while seated in wheelchairs.

Occupant restraint systems are designed based on knowledge of crash dynamics and the application of proven occupant-protection principles. For ambulatory children or children who use wheelchairs but can transfer out of their wheelchair when traveling in motor vehicles, there is a range of child safety seats that comply with federal safety standards and that therefore offer high levels of crash protection. For children who remain seated in wheelchairs for travel, the use of wheelchairs and wheelchair tiedown and occupant restraint systems (WTORS) that comply with voluntary industry standards significantly enhances safety. Revisions to the initial versions of these standards will further improve safety for smaller children who travel seated in wheelchairs by requiring wheelchairs for children between 13 and 22 kg (18 and 50 lb) to provide a five-point, wheelchair-integrated crash-tested harness similar to that used in forward-facing child safety seats. While wheelchair and tiedown/restraint manufacturers, van modifiers, transportation personnel, clinicians, and others involved with children who use wheelchairs have clearly defined responsibilities relative to providing these children with safe transportation, parents and caregivers should be knowledgeable about best-practice in wheelchair transportation safety and should use this knowledge to advocate for the safest transportation possible.

Biomechanical assessment of a rear-seat inflatable seatbelt in frontal impacts.

This study evaluated the biomechanical performance of a rear-seat inflatable seatbelt system and compared it to that of a 3-point seatbelt system, which has a long history of good real-world performance. Frontal-impact sled tests were conducted with Hybrid III anthropomorphic test devices (ATDs) and with post mortem human subjects (PMHS) using both restraint systems and a generic rear-seat configuration. Results from these tests demonstrated: a) reduction in forward head excursion with the inflatable seatbelt system when compared to that of a 3-point seatbelt and; b) a reduction in ATD and PMHS peak chest deflections and the number of PMHS rib fractures with the inflatable seatbelt system and c) a reduction in PMHS cervical-spine injuries, due to the interaction of the chin with the inflated shoulder belt. These results suggest that an inflatable seatbelt system will offer additional benefits to some occupants in the rear seats. Further research is needed to assess the field effectiveness, customer comfort and acceptance and change in the belt usage rate with the inflatable seatbelt system.

A stochastic visco-hyperelastic model of human placenta tissue for finite element crash simulations.

Placental abruption is the most common cause of fetal deaths in motor-vehicle crashes, but studies on the mechanical properties of human placenta are rare. This study presents a new method of developing a stochastic visco-hyperelastic material model of human placenta tissue using a combination of uniaxial tensile testing, specimen-specific finite element (FE) modeling, and stochastic optimization techniques. In our previous study, uniaxial tensile tests of 21 placenta specimens have been performed using a strain rate of 12/s. In this study, additional uniaxial tensile tests were performed using strain rates of 1/s and 0.1/s on 25 placenta specimens. Response corridors for the three loading rates were developed based on the normalized data achieved by test reconstructions of each specimen using specimen-specific FE models. Material parameters of a visco-hyperelastic model and their associated standard deviations were tuned to match both the means and standard deviations of all three response corridors using a stochastic optimization method. The results show a very good agreement between the tested and simulated response corridors, indicating that stochastic analysis can improve estimation of variability in material model parameters. The proposed method can be applied to develop stochastic material models of other biological soft tissues.

BioTab--a new method for analyzing and documenting injury causation in motor-vehicle crashes.

OBJECTIVE: To describe a new method for analyzing and documenting the causes of injuries in motor vehicle crashes that has been implemented since 2005 in cases investigated by the Crash Injury Research Engineering Network (CIREN). METHODS: The new method, called BioTab, documents injury causation using evidence from in-depth crash investigations. BioTab focuses on developing injury causation scenarios (ICSs) that document all factors considered essential for an injury to have occurred as well as factors that contributed to the likelihood and/or severity of an injury. The elements of an injury causation scenario are (1) the source of the energy that caused the injury, (2) involved physical components (IPCs) contacted by the occupant that are considered necessary for the injury to have occurred, (3) the body region or regions contacted by each IPC, (4) the internal paths between body regions contacted by IPCs and the injured body region, (5) critical intrusions of vehicle components, and (6) factors that contributed to the likelihood and/or the severity of injury. RESULTS: Advantages of the BioTab method are that it attempts to identify all factors that cause or contribute to clinically significant injuries, allows for coding of scenarios where one injury causes another injury, associates injuries with a source of energy and allows injuries to be associated with sources of energy other than the crash, such as air bag deployment energy, allows for documenting scenarios where an injury was caused by two different body regions contacting two different IPCs, identifies and documents the evidence that supports ICSs and IPCs, assigns confidence levels to ICSs and IPCs based on available evidence, and documents body region and organ/component-level "injury mechanisms" and distinguishes these mechanisms from ICSs. CONCLUSION: The BioTab method provides for methodical and thorough evidenced-based analysis and documentation of injury causation in motor vehicle crashes.

WC19: a wheelchair transportation safety standard--experience to date and future directions.

ANSI/RESNA WC19 (i.e., WC19) is a voluntary standard that specifies design and performance requirements for wheelchairs that are suitable for use as seats in motor vehicles. The guiding principles for the standard originate from automotive crash-protection principles that are effective in reducing occupant injuries and fatalities. In addition to frontal-impact testing of wheelchairs, the standard includes tests for securement-point accessibility, tiedown-strap clear paths, lateral stability, and accommodation of vehicle-anchored belt restraints. Results from testing wheelchairs to WC19 reveal that the most common wheelchair problems include: a lack of structural integrity during frontal-impact loading; sharp rigid edges; and wheelchair structures that interfere with achieving proper positioning of vehicle-anchored belt restraints. Data from 8 years of experience with WC19 indicate where changes are needed to further improve transportation safety for wheelchair-seated travelers. These include expanding WC19 to include wheelchairs for smaller children who require a five-point harness restraint, and requiring wheelchairs to achieve a minimal rating for the ease of achieving proper positioning of vehicle-anchored belt restraints.

Using in-depth investigations to identify transportation safety issues for wheelchair-seated occupants of motor vehicles.

In-depth investigations of motor-vehicle crashes involve detailed inspection, measurement, and photodocumentation of vehicle exterior and interior damage, evidence of belt-restraint use, and evidence of occupant contacts with the vehicle interior. Results of in-depth investigations thereby provide the most objective way to identify current and emerging injury problems and issues in occupant safety and crash protection, and provide important feedback on the real-world performance of the latest restraint-system and vehicle crashworthiness technologies. To provide an objective understanding of real-world transportation safety issues for wheelchair-seated travelers, the University of Michigan Transportation Research Institute (UMTRI) has been conducting and assembling data from in-depth investigations of motor-vehicle crashes and non-crash adverse moving-vehicle incidents, such as emergency vehicle braking, turning, and swerving, in which there was at least one vehicle occupant sitting in a wheelchair. The results of 39 investigations involving 42 wheelchair-seated occupants have been assembled and entered into a wheelchair-occupant crash/injury database. In addition, a biomechanical analysis of each case has been performed to identify key safety issues for wheelchair-seated travelers. The wheelchairs of 34 of the 42 occupants who were seated in wheelchairs while traveling in motor vehicles were effectively secured by either a four-point, strap-type tiedown system or a docking securement device, and all but one of these properly secured wheelchairs remained in place during the crash or non-collision event. However, 30 of the 42 occupants were improperly restrained, either because of non-use or incomplete use of available belt restraints, or because the belt restraints were improperly positioned on the occupant's body. Twenty-six of the 42 occupants sustained significant injuries and 10 of these occupants died as a direct result of injuries sustained, or from complications resulting from those injuries. These findings, when combined with the analyses of the individual cases, point to a need for better driver and caregiver education and training on how to properly secure wheelchairs and position belt restraints on wheelchair-seated passengers. They also point to a need for improved restraint systems used by wheelchair-seated drivers, and a need for wheelchair designs that facilitate the proper use and positioning of vehicle-anchored belt restraints.

Factors associated with abdominal injury in frontal, farside, and nearside crashes.

The NASS-CDS (1998-2008) and CIREN datasets were analyzed to identify factors contributing to abdominal injury in crash environments where belt use and airbag deployment are common. In frontal impacts, the percentage of occupants sustaining abdominal injury is three times higher for unbelted compared to belted front-row adult occupants (p<0.0001) at both AIS2+ and AIS3+ injury levels. Airbag deployment does not substantially affect the percentage of occupants who sustain abdominal injuries in frontal impacts (p=0.6171), while belt use reduces the percentage of occupants sustaining abdominal injury in both nearside and farside crashes (p<0.0001). Right-front passengers in right-side impacts have the highest risk (1.91%) of AIS 3+ abdominal injury (p=0.03). The percentage of occupants with AIS 3+ abdominal injuries does not vary with age for frontal, nearside, or farside impacts. If an occupant sustains AIS 2+ rib fractures, the odds of the occupant sustaining an AIS 2+ abdominal injury increase dramatically. The percentage of occupants with AIS2+ abdominal injury decreases 67% for occupants in 2001-2009 model-year vehicles compared to occupants in 1985-1992 model-year vehicles. For drivers in frontal impacts, the most common vehicle-component contacts associated with abdominal injury are the steering-wheel and the lap/shoulder belt, whereas the lap/shoulder belt is the most common contact associated with abdominal injuries for right-front passengers. For occupants in nearside impacts with both liver and spleen injuries, the mean lateral door intrusion is nearly 33 cm,, while mean door intrusions range from 26 to 30 cm for occupants with only liver or only spleen injury.

Quantifying dynamic mechanical properties of human placenta tissue using optimization techniques with specimen-specific finite-element models.

Motor-vehicle crashes are the leading cause of fetal deaths resulting from maternal trauma in the United States, and placental abruption is the most common cause of these deaths. To minimize this injury, new assessment tools, such as crash-test dummies and computational models of pregnant women, are needed to evaluate vehicle restraint systems with respect to reducing the risk of placental abruption. Developing these models requires accurate material properties for tissues in the pregnant abdomen under dynamic loading conditions that can occur in crashes. A method has been developed for determining dynamic material properties of human soft tissues that combines results from uniaxial tensile tests, specimen-specific finite-element models based on laser scans that accurately capture non-uniform tissue-specimen geometry, and optimization techniques. The current study applies this method to characterizing material properties of placental tissue. For 21 placenta specimens tested at a strain rate of 12/s, the mean failure strain is 0.472+/-0.097 and the mean failure stress is 34.80+/-12.62 kPa. A first-order Ogden material model with ground-state shear modulus (mu) of 23.97+/-5.52 kPa and exponent (alpha(1)) of 3.66+/-1.90 best fits the test results. The new method provides a nearly 40% error reduction (p<0.001) compared to traditional curve-fitting methods by considering detailed specimen geometry, loading conditions, and dynamic effects from high-speed loading. The proposed method can be applied to determine mechanical properties of other soft biological tissues.