Detalhe da pesquisa
1.
The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia.
Pharmacol Res
; 160: 105058, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32619722
2.
Anticancer potential of naturally occurring immunoepigenetic modulators: A promising avenue?
Cancer
; 125(10): 1612-1628, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30840315
3.
Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways.
Pharmacol Res
; 129: 337-356, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29133216
4.
Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1'(R), 6'(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax.
Mar Drugs
; 16(12)2018 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30572618
5.
The Fungal Metabolite Eurochevalierine, a Sequiterpene Alkaloid, Displays Anti-Cancer Properties through Selective Sirtuin 1/2 Inhibition.
Molecules
; 23(2)2018 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29401749
6.
Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer.
Molecules
; 21(11)2016 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27886118
7.
The DNA hypomethylating agent, 5-aza-2'-deoxycytidine, enhances tumor cell invasion through a transcription-dependent modulation of MMP-1 expression in human fibrosarcoma cells.
Mol Carcinog
; 54(1): 24-34, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24038389
8.
Novel inhibitors of human histone deacetylases: design, synthesis and bioactivity of 3-alkenoylcoumarines.
Bioorg Med Chem Lett
; 24(16): 3797-801, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25042254
9.
Bis(4-hydroxy-2H-chromen-2-one): synthesis and effects on leukemic cell lines proliferation and NF-κB regulation.
Bioorg Med Chem
; 22(11): 3008-15, 2014 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24775915
10.
Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
J Nat Prod
; 77(1): 49-56, 2014 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24328302
11.
Antileukemic potential of methylated indolequinone MAC681 through immunogenic necroptosis and PARP1 degradation.
Biomark Res
; 12(1): 47, 2024 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38704604
12.
Susceptibility of multiple myeloma to B-cell lymphoma 2 family inhibitors.
Biochem Pharmacol
; 188: 114526, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33741332
13.
Discovery of Sulforaphane as an Inducer of Ferroptosis in U-937 Leukemia Cells: Expanding Its Anticancer Potential.
Cancers (Basel)
; 14(1)2021 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35008240
14.
Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription.
J Neurochem
; 113(2): 418-31, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20096088
15.
Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation.
Mol Cell Biol
; 27(20): 7089-101, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17682057
16.
HDAC6-an Emerging Target Against Chronic Myeloid Leukemia?
Cancers (Basel)
; 12(2)2020 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32013157
17.
Epigenetic mechanisms underlying the therapeutic effects of HDAC inhibitors in chronic myeloid leukemia.
Biochem Pharmacol
; 173: 113698, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31706847
18.
Human telomerase reverse transcriptase depletion potentiates the growth-inhibitory activity of imatinib in chronic myeloid leukemia stem cells.
Cancer Lett
; 469: 468-480, 2020 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31734352
19.
Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells.
Clin Epigenetics
; 12(1): 69, 2020 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32430012
20.
Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia.
Cell Death Dis
; 11(2): 109, 2020 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32034134