Detalhe da pesquisa
1.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Cell
; 161(6): 1252-65, 2015 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26046436
2.
Repurposing p97 inhibitors for chemical modulation of the bacterial ClpB-DnaK bichaperone system.
J Biol Chem
; 296: 100079, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33187983
3.
Revisiting the ß-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach.
Antimicrob Agents Chemother
; 63(11)2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31427291
4.
A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism.
J Neurosci
; 36(28): 7441-52, 2016 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27413154
5.
Threading the Needle: Small-Molecule Targeting of a Xenobiotic Receptor to Ablate Escherichia coli Polysaccharide Capsule Expression Without Altering Antibiotic Resistance.
J Infect Dis
; 213(8): 1330-9, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26671885
6.
Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.
Bioorg Med Chem
; 23(14): 3948-56, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25593096
7.
Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis.
J Biol Chem
; 288(27): 19949-57, 2013 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23703611
8.
Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays.
Nucleic Acids Res
; 40(17): 8607-21, 2012 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22740655
9.
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.
Proc Natl Acad Sci U S A
; 108(12): 4834-9, 2011 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21383145
10.
Skeletal diversification via heteroatom linkage control: preparation of bicyclic and spirocyclic scaffolds from N-substituted homopropargyl alcohols.
J Org Chem
; 78(8): 3720-30, 2013 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23510238
11.
Benzylmorpholine analogs as selective inhibitors of lung cytochrome P450 2A13 for the chemoprevention of lung cancer in tobacco users.
Pharm Res
; 30(9): 2290-302, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23756756
12.
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Bioorg Med Chem Lett
; 23(12): 3654-61, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23642479
13.
Novel compound C150 inhibits pancreatic cancer through induction of ER stress and proteosome assembly.
Front Oncol
; 12: 870473, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36276125
14.
DNAJA1- and conformational mutant p53-dependent inhibition of cancer cell migration by a novel compound identified through a virtual screen.
Cell Death Discov
; 8(1): 437, 2022 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36316326
15.
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
J Med Chem
; 65(12): 8303-8331, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35696646
16.
Novel Compound C150 Inhibits Pancreatic Cancer Cell Epithelial-to-Mesenchymal Transition and Tumor Growth in Mice.
Front Oncol
; 11: 773350, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34976816
17.
Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases.
Front Microbiol
; 11: 1248, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32655524
18.
Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay.
SLAS Discov
; 24(1): 38-46, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30142014
19.
Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.
J Antibiot (Tokyo)
; 72(6): 469-475, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30903100
20.
Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.
Sci Transl Med
; 10(441)2018 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29769289