Detalhe da pesquisa
1.
ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.
Drug Resist Updat
; 72: 101017, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37988981
2.
Genetic effects on liver chromatin accessibility identify disease regulatory variants.
Am J Hum Genet
; 108(7): 1169-1189, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34038741
3.
Zebrafish abcb11b mutant reveals strategies to restore bile excretion impaired by bile salt export pump deficiency.
Hepatology
; 67(4): 1531-1545, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29091294
4.
SUGP1 is a novel regulator of cholesterol metabolism.
Hum Mol Genet
; 25(14): 3106-3116, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27206982
5.
Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism.
Pharmacogenet Genomics
; 28(1): 7-16, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29232328
6.
Pheophorbide A: Fluorescent Bcrp Substrate to Measure Oral Drug-Drug Interactions in Real-Time In Vivo.
Drug Metab Dispos
; 46(11): 1725-1733, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30111622
7.
Ketamine Pharmacokinetics and Pharmacodynamics Are Altered by P-Glycoprotein and Breast Cancer Resistance Protein Efflux Transporters in Mice.
Drug Metab Dispos
; 46(7): 1014-1022, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29674491
8.
Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions.
Drug Metab Dispos
; 46(5): 567-580, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29514827
9.
Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans.
Drug Metab Dispos
; 46(4): 367-379, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29343609
10.
Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.
Drug Metab Dispos
; 46(6): 888-896, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29602798
11.
Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors.
J Pharmacol Exp Ther
; 360(1): 129-139, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27815364
12.
Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.
J Pharmacol Exp Ther
; 363(2): 265-274, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28819071
13.
CRISPR/Cas9 Genetic Modification of CYP3A5 *3 in HuH-7 Human Hepatocyte Cell Line Leads to Cell Lines with Increased Midazolam and Tacrolimus Metabolism.
Drug Metab Dispos
; 45(8): 957-965, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533324
14.
Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver.
Drug Metab Dispos
; 44(7): 999-1004, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27098745
15.
Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.
Drug Metab Dispos
; 44(3): 343-51, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26681736
16.
In Vivo Imaging of Human MDR1 Transcription in the Brain and Spine of MDR1-Luciferase Reporter Mice.
Drug Metab Dispos
; 43(11): 1646-54, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26281846
17.
The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles.
Drug Metab Dispos
; 43(8): 1226-35, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26021325
18.
Why do most human liver cytosol preparations lack xanthine oxidase activity?
Drug Metab Dispos
; 42(4): 695-9, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24430612
19.
Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction.
Mol Cell Proteomics
; 11(2): M111.010132, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22101235
20.
Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue.
PLoS Genet
; 7(5): e1002078, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21637794