RESUMO
In 4 double-blind, randomized, stratified, parallel group studies, single oral doses of fluproquazone (75 to 200 mg), a new nonsteroidal anti-inflammatory analgesic, were compared with aspirin (1,000 mg) and placebo in a total of 672 hospitalized patients with moderate or severe pain following episiotomy or other surgical interventions. A dose-dependent effect of fluproquazone which was highly significantly superior to placebo and which resembled the effect of aspirin with respect to onset, degree, and duration was noted in all studies. Fluproquazone, 100 to 150 mg, was found to be approximately equiactive to 1,000 mg of aspirin and better tolerated.
Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Dor Pós-Operatória/tratamento farmacológico , Quinazolinas/uso terapêutico , Adulto , Anti-Inflamatórios não Esteroides/efeitos adversos , Aspirina/uso terapêutico , Ensaios Clínicos como Assunto , Relação Dose-Resposta a Droga , Episiotomia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , QuinazolinonasAssuntos
Úlcera Péptica/cirurgia , Complicações Pós-Operatórias/cirurgia , Anemia , Peso Corporal , Diarreia/etiologia , Drenagem , Síndrome de Esvaziamento Rápido/etiologia , Seguimentos , Gastroenterostomia , Humanos , Osteomalacia , Úlcera Péptica/etiologia , Síndromes Pós-Gastrectomia/diagnóstico por imagem , Síndromes Pós-Gastrectomia/cirurgia , Complicações Pós-Operatórias/diagnóstico por imagem , Piloro/cirurgia , Radiografia , Recidiva , Fatores de Tempo , Vagotomia , Vômito/etiologiaRESUMO
The posttraumatic pneumatocele is a rare intrapulmonary lesion following blunt thoracic injury. By means of a well documented case report this rare form of lung contusion is demonstrated and the clinically important differential diagnosis is discussed.
Assuntos
Cistos/diagnóstico , Lesão Pulmonar , Ferimentos não Penetrantes/diagnóstico , Adulto , Contusões/diagnóstico , Feminino , Hematocele/diagnóstico , Humanos , MasculinoRESUMO
Both chenodeoxycholic acid, in the dosage administered for dissolution of gallstones, and cholic acid are completely conjugated during one passage through the liver. The glycine:taurine ratio increases with the cumulative amount of exogenous bile acids secreted, which suggests consumption of available taurine. Since conjugation with glycine compensates for deficiency of the taurine conjugating system, it can be assumed that in the normal liver and with doses not exceeding 2.5 mmoles, chenodeoxycholic acid is efficiently and completely transformed into its "physiologic" conjugated form.
Assuntos
Ácido Quenodesoxicólico/metabolismo , Ácidos Cólicos/metabolismo , Fígado/metabolismo , Ácidos e Sais Biliares/metabolismo , Ácido Quenodesoxicólico/administração & dosagem , Colelitíase/tratamento farmacológico , Ácidos Cólicos/administração & dosagem , Ácidos Cólicos/uso terapêutico , Glicina/metabolismo , Humanos , Taurina/metabolismoRESUMO
A multicentric, double-blind, randomized, parallel-group study was performed in patients with fever of diverse origin to test the tolerance and the antipyretic activity of single oral doses of 4-(p-fluorophenyl)-1-isopropyl-7-methyl-2(1H)-quinazolinone (fluproquazone) (200 mg, n = 18), acetylsalicylic acid (ASA) (1000 mg, n = 22) and placebo (n = 19). Whereas with placebo mean rectal temperature remained constant, a continuous fall was recorded with both active medications over the whole 3-h study period. With fluproquazone normalization of body temperature was nearly reached. Fluproquazone was more effective than placebo (p less than 0.001) and ASA (p less than 0.1), which in turn was more active than placebo (p less than 0.0001). No specific side-effects occurred.