Detalhe da pesquisa
1.
Aldosterone synthase inhibitor (BI 690517) therapy for people with diabetes and albuminuric chronic kidney disease: A multicentre, randomized, double-blind, placebo-controlled, Phase I trial.
Diabetes Obes Metab
; 26(6): 2128-2138, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38497241
2.
Safety, tolerability, pharmacodynamics and pharmacokinetics of the soluble guanylyl cyclase activator BI 685509 in patients with diabetic kidney disease: A randomized trial.
Diabetes Obes Metab
; 25(8): 2218-2226, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37232058
3.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of BI 685509, a soluble guanylyl cyclase activator, in healthy volunteers: Results from two randomized controlled trials.
Naunyn Schmiedebergs Arch Pharmacol
; 2024 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38789635
4.
Perspectives on a Way Forward to Implementation of Precision Medicine in Patients With Diabetic Kidney Disease; Results of a Stakeholder Consensus-Building Meeting.
Front Pharmacol
; 12: 662642, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34025424
5.
Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community.
Circulation
; 119(12): 1592-600, 2009 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-19289633
6.
Association of the endogenous nitric oxide synthase inhibitor ADMA with carotid artery intimal media thickness in the Framingham Heart Study offspring cohort.
Stroke
; 40(8): 2715-9, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19498184
7.
Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study.
Stroke
; 40(9): 2959-64, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19644064
8.
Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohort.
Clin Chem
; 55(8): 1539-45, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19541865
9.
Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality--an update on patient populations with a wide range of cardiovascular risk.
Pharmacol Res
; 60(6): 481-7, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19596069
10.
Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.
Br J Clin Pharmacol
; 65(1): 51-9, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17662090
11.
Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease.
Dement Geriatr Cogn Disord
; 26(1): 58-64, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18617736
12.
Pharmacokinetics of oral doses of telmisartan and nisoldipine, given alone and in combination, in patients with essential hypertension.
J Clin Pharmacol
; 47(3): 295-304, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17322141
13.
A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue.
J Chromatogr B Analyt Technol Biomed Life Sci
; 851(1-2): 220-8, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17296339
14.
High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 851(1-2): 211-9, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17194630
15.
Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study.
Am Heart J
; 152(3): 493.e1-8, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16923419
16.
Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension.
Metabolism
; 55(9): 1159-64, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16919533
17.
Dabigatran treatment simulation in patients undergoing maintenance haemodialysis.
Thromb Haemost
; 115(3): 562-9, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26467062
18.
Determination of NG,NG-dimethyl-L-arginine, an endogenous NO synthase inhibitor, by gas chromatography-mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
; 809(1): 59-65, 2004 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-15282094
19.
Comparison of HPLC method and commercial ELISA assay for asymmetric dimethylarginine (ADMA) determination in human serum.
J Chromatogr B Analyt Technol Biomed Life Sci
; 831(1-2): 333, 2006 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16324891
20.
Symmetric dimethylarginine predicts all-cause mortality following ischemic stroke.
Atherosclerosis
; 208(2): 518-23, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700158