Detalhe da pesquisa
1.
Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain.
J Biol Chem
; 299(9): 105112, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37517692
2.
Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281.
J Biol Chem
; 299(4): 103032, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36806682
3.
Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate.
J Biol Chem
; 299(8): 104993, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37392852
4.
Human cytochrome P450 17A1 structures with metabolites of prostate cancer drug abiraterone reveal substrate-binding plasticity and a second binding site.
J Biol Chem
; 299(3): 102999, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36773804
5.
Tracking protein-protein interactions by NMR: conformational selection in human steroidogenic cytochrome P450 CYP17A1 induced by cytochrome b5.
Phys Chem Chem Phys
; 26(24): 16980-16988, 2024 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38842434
6.
The structure and characterization of human cytochrome P450 8B1 supports future drug design for nonalcoholic fatty liver disease and diabetes.
J Biol Chem
; 298(9): 102344, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35944583
7.
Four Decades of Cytochrome P450 2B Research: From Protein Adducts to Protein Structures and Beyond.
Drug Metab Dispos
; 51(1): 111-122, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36310033
8.
Covariational reasoning and item context affect language in undergraduate mass balance written explanations.
Adv Physiol Educ
; 47(4): 762-775, 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37615044
9.
Oaks to arteries: the Physiology Core Concept of flow down gradients supports transfer of student reasoning.
Adv Physiol Educ
; 47(2): 282-295, 2023 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36727693
10.
Structural and functional insights into aldosterone synthase interaction with its redox partner protein adrenodoxin.
J Biol Chem
; 296: 100794, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34015331
11.
Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents.
Drug Metab Dispos
; 50(1): 49-57, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34607808
12.
Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability.
J Biol Chem
; 295(17): 5640-5653, 2020 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32156703
13.
Effects of fluorine substitution on substrate conversion by cytochromes P450 17A1 and 21A2.
Org Biomol Chem
; 19(35): 7664-7669, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34524336
14.
Structure of human cortisol-producing cytochrome P450 11B1 bound to the breast cancer drug fadrozole provides insights for drug design.
J Biol Chem
; 294(2): 453-460, 2019 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30425102
15.
Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX).
Drug Metab Rev
; 52(3): 395-407, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32456484
16.
Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate.
Drug Metab Dispos
; 48(2): 86-92, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31757797
17.
Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents.
Int J Mol Sci
; 21(14)2020 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32660148
18.
Endogenous insertion of non-native metalloporphyrins into human membrane cytochrome P450 enzymes.
J Biol Chem
; 293(43): 16623-16634, 2018 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30217815
19.
Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands.
J Biol Chem
; 293(50): 19201-19210, 2018 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30254074
20.
Correction: Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate.
J Biol Chem
; 299(10): 105283, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37783037