Detalhe da pesquisa
1.
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Bioorg Med Chem Lett
; 23(9): 2743-9, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23522834
2.
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.
Bioorg Med Chem Lett
; 21(18): 5521-7, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21813278
3.
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Bioorg Med Chem Lett
; 21(1): 315-9, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21112785
4.
Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.
Bioorg Med Chem Lett
; 20(24): 7303-7, 2010 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21071223
5.
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Bioorg Med Chem Lett
; 20(21): 6231-6, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20833041
6.
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Bioorg Med Chem Lett
; 20(20): 6034-9, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20822903
7.
Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.
Bioorg Med Chem Lett
; 20(16): 4789-94, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20634069
8.
Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.
Bioorg Med Chem Lett
; 19(22): 6386-91, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19811916
9.
Structure and Energetics of the Samarium Diiodide-HMPA Complex in Tetrahydrofuran.
J Org Chem
; 64(14): 5251-5255, 1999 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34237851